Scientists have successfully grown beating human hearts inside pig embryos for the first time, marking a significant advance in developing human-animal chimeras for potential organ transplantation. The hybrid embryos survived for 21 days, during which the fingertip-sized hearts began beating, according to findings presented at the International Society for Stem Cell Research meeting in Hong Kong.

Researchers -- led by Lai Liangxue at the Guangzhou Institutes of Biomedicine and Health -- reprogrammed human stem cells to survive in pigs and introduced them into pig embryos with two heart development genes knocked out. The human cells, tagged with luminescent biomarkers, were visible glowing within the developing hearts.

The European Space Agency's Solar Orbiter has captured the first-ever images of the sun's poles by tilting its orbit out of the ecliptic plane. Space.com reports: The captured images of the solar south pole were taken between March 16 and 17, 2025, with the Solar Orbiter's Polarimetric and Helioseismic Imager (PHI), Extreme Ultraviolet Imager (EUI), and Spectral Imaging of the Coronal Environment (SPICE) instruments. They constitute humanity's first ever look at the sun's poles. This was the Solar Orbiter mission's first high-angle observation campaign of the sun, conducted at an angle of 15 degrees below the solar equator. Just a few days after snapping these images, the ESA spacecraft reached a maximum viewing angle of 17 degrees, which it sits in currently as it performs its first "pole-to-pole" orbit of our star. [...]

One of the first discoveries made by the Solar Orbiter is the fact that the magnetic fields around the sun's southern poles appear to be, for lack of a better phrase, a complete mess. While standard magnetic fields have well-defined north and south poles, these new observations reveal that north and south polarities are both found at the sun's southern pole. This seems to happen at solar maximum when the poles of the sun are about to flip. Following this exchange of poles, the fields at the north and south poles will maintain an orderly single polarity during solar minimum until solar maximum during the next 11-year cycle.

The Solar Orbiter observations also revealed that while the equator of the sun, where the most sunspots appear, possesses the strongest magnetic fields, those at the poles of our star have a complex and ever-changing structure. The Solar Orbiter's SPICE instrument provided another first for the ESA spacecraft, allowing scientists to track elements via their unique emissions as they move through the sun. Tracing the specific spectral lines of elements like hydrogen, carbon, oxygen, neon, and magnesium, a process called "Doppler measurement," revealed how materials flow through different layers of the sun. The Solar Orbiter also allowed scientists to measure the speed of carbon atoms as they are ejected from the sun in plumes and jets. "This is just the first step of Solar Orbiter's 'stairway to heaven.' In the coming years, the spacecraft will climb further out of the ecliptic plane for ever better views of the sun's polar regions," ESA's Solar Orbiter project scientist Daniel Muller said. "These data will transform our understanding of the sun's magnetic field, the solar wind, and solar activity."

Since filing for bankruptcy in March, 23andMe has received data deletion requests from 1.9 million users -- around 15% of its customer base. That number was revealed by 23andMe's interim chief executive Joseph Selsavage during a House Oversight Committee hearing, during which lawmakers scrutinized the company's sale following an earlier bankruptcy auction. "The bankruptcy sparked concerns that the data of millions of Americans who used 23andMe could end up in the hands of an unscrupulous buyer, prompting customers to ask the company to delete their data," adds TechCrunch. From the report: Pharmaceutical giant Regeneron won the court-approved auction in May, offering $256 million for 23andMe and its banks of customers' DNA and genetic data. Regeneron said it would use the 23andMe data to aid the discovery of new drugs, and committed to maintain 23andMe's privacy practices. Truly deleting your personal genetic information from the DNA testing company is easier said than done. But if you were a 23andMe customer and are interested, MIT Technology Review outlines that steps you can take.

The Vera C. Rubin Observatory in Chile will begin full operations in the coming months with the world's largest digital camera, capturing 3,200-megapixel images that would require several hundred HD television screens to display at full resolution. The $810 million facility will map the entire southern sky every three to four nights, observing each location approximately 800 times over its planned decade of operations.

The telescope's unusual design allows it to photograph an area equivalent to 45 full moons in each shot and swing between different sky locations every 40 seconds. Its digital camera, roughly the size of a small car, will generate eight million alerts per night when it detects astronomical objects that move or change brightness, according to Tony Tyson, the University of California, Davis astronomer who conceived the project in the 1990s. Astrophysicist Federica Bianco, who received a preview of the telescope's first full-color image, described her reaction simply: "There are so many stars!" The team plans to unveil that inaugural image on June 23.

The FDA plans to use AI to "radically increase efficiency" in deciding whether to approve new drugs and devices, drawing on lessons from Operation Warp Speed to reduce review times to weeks. The plan was laid out in an article published Tuesday in JAMA. The New York Times reports: Another initiative involves a review of chemicals and other "concerning ingredients" that appear in U.S. food but not in the food of other developed nations. And officials want to speed up the final stages of making a drug or medical device approval decision to mere weeks, citing the success of Operation Warp Speed during the Covid pandemic when workers raced to curb a spiraling death count. [...]

Last week, the agency introduced Elsa, an artificial intelligence large-language model similar to ChatGPT. The FDA said it could be used to prioritize which food or drug facilities to inspect, to describe side effects in drug safety summaries and to perform other basic product-review tasks. The FDA officials wrote that A.I. held the promise to "radically increase efficiency" in examining as many as 500,000 pages submitted for approval decisions.

Current and former health officials said the A.I. tool was helpful but far from transformative. For one, the model limits the number of characters that can be reviewed, meaning it is unable to do some rote data analysis tasks. Its results must be checked carefully, so far saving little time. Staff members said that the model was hallucinating, or producing false information. Employees can ask the Elsa model to summarize text or act as an expert in a particular field of medicine.

A mathematician on Reddit calculated that if all 8.2 billion humans were blended into a uniform goo, the resulting meatball would form a sphere just under 1 kilometer wide -- small enough to fit inside Central Park. ScienceAlert reports: "If you blended all 7.88 billion people on Earth into a fine goo (density of a human = 985 kg/m3, average human body mass = 62 kg), you would end up with a sphere of human goo just under 1 km wide," Reddit contributor kiki2703 wrote in a post ... Reasoning the density of a minced human to be 985 kilograms per cubic meter (62 pounds per cubic foot) is a fair estimate, given past efforts have judged our jiggling sack of grade-A giblets to average out in the ballpark of 1 gram per cubic centimeter, or roughly the same as water. And in mid-2021, the global population was just around 7.9 billion, give or take.

A NASA-backed project using observations from the James Webb Space Telescope (JWST) has released more than 1.5 TB of data for open science, offering the largest view deep into the universe available to date. From a report: The Cosmic Evolution Survey (COSMOS), a joint project from the University of California, Santa Barbara and Rochester Institute of Technology, has launched a searchable dataset for budding astrophysics enthusiasts worldwide.

As well as a catalog of galaxies, the dataset includes an interactive viewer that users can search for images of specific objects or click them to view their properties, covering approximately 0.54 square degrees of sky with the Near Infrared Camera (NIRCam) and a 0.2 square degree area with the Mid Infrared Instrument (MIRI). Although the raw data was already publicly available to the science community, the aim of the COSMOS-Web project was to make it more usable for other scientists.

A group of 20 internationally renowned scientists have issued a strong warning against attempts to narrow the definition of "forever chemicals" in what they describe as a politically or economically motivated effort to weaken regulation of the potentially harmful chemicals. From a report: Per- and polyfluoroalkyl substances (Pfas) are a large group of synthetic chemicals used for their oil-, water- and stain-resistant properties in a range of consumer and industrial products from waterproof clothing and non-stick cookware to firefighting foams and electronics.

Their molecular structure makes them resistant to degradation, earning them the nickname "forever chemicals." In the last few years there has been growing awareness of the problems associated with Pfas, and a push for more stringent regulation, resulting in the banning of certain forms. A group of scientists are now raising the alarm about efforts, including by some individuals and groups in the International Union of Pure and Applied Chemistry (IUpac), to narrow the current international definition of Pfas in ways that could exclude certain chemical subgroups.

Blue Origin is falling far short of its goal to launch the New Glenn rocket eight times in 2025, with its second flight now delayed until at least mid-August. Key leadership changes were also announced, including the departure of the New Glenn program head, as the company faces pressure to increase launch cadence and compete with SpaceX for federal contracts and Amazon's Project Kuiper deployments. Ars Technica reports: The mission, with an undesignated payload, will be named "Never Tell Me the Odds," due to the attempt to land the booster. "One of our key mission objectives will be to land and recover the booster," [chief executive of Blue Origin, Dave Limp] wrote. "This will take a little bit of luck and a lot of excellent execution. We're on track to produce eight GS2s this year, and the one we'll fly on this second mission was hot-fired in April."

In this comment, GS2 stands for "Glenn stage 2," or the second stage of the large rocket. It is telling that Limp commented on the company tracking toward producing eight second stages, which would match the original launch cadence planned for this year. This likely is a fig leaf offered to Bezos, who, two sources said, was rather upset that Blue Origin would not meet (or even approach) its original target of eight launches this year. One person familiar with the progress on the vehicle told Ars that even a launch date in August is unrealistic -- this too may have been set aggressively to appease Bezos -- and that September is probably the earliest the rocket is likely to be ready for launch. Blue Origin has not publicly stated what the payload will be, but this second flight is expected to carry the ESCAPADE mission for NASA.

On May 28, a couple of days after Limp's all-hands meeting, the chief executive emailed his entire team to announce an "organizational update." As part of this, the company's senior vice president of engines, Linda Cova, was retiring. Multiple sources confirmed this retiring was expected and that the company's program to produce BE-4 rocket engines is going well. However, the other name in the email raised some eyebrows, coming so soon after the announcement that New Glenn's cadence would be significantly slower than expected. Jarrett Jones, the senior vice president running the New Glenn program, was said to be "stepping away from his role and taking a well deserved year off" starting on August 15. It is unclear whether this departure was linked to Bezos' displeasure with the rocket program. One company official said Jones' sabbatical had been planned, but the timing is curious. A search for internal and external candidates to fill his role is ongoing.

The world's oceans are in worse health than realised, scientists have said today, as they warn that a key measurement shows we are "running out of time" to protect marine ecosystems. From a report: Ocean acidification, often called the "evil twin" of the climate crisis, is caused when carbon dioxide is rapidly absorbed by the ocean, where it reacts with water molecules leading to a fall in the pH level of the seawater. It damages coral reefs and other ocean habitats and, in extreme cases, can dissolve the shells of marine creatures.

Until now, ocean acidification had not been deemed to have crossed its "planetary boundary." The planetary boundaries are the natural limits of key global systems -- such as climate, water and wildlife diversity -- beyond which their ability to maintain a healthy planet is in danger of failing. Six of the nine had been crossed already, scientists said last year. However, a new study by the UK's Plymouth Marine Laboratory (PML), the Washington-based National Oceanic and Atmospheric Administration and Oregon State University's Co-operative Institute for Marine Resources Studies found that ocean acidification's "boundary" was also reached about five years ago.

Vox publishes a story about "the quiet revolutions that have prevented millions of cancer deaths....

"The age-adjusted death rate in the US for cancer has declined by about a third since 1991, meaning people of a given age have about a third lower risk of dying from cancer than people of the same age more than three decades ago... " The dramatic bend in the curve of cancer deaths didn't happen by accident — it's the compound interest of three revolutions. While anti-smoking policy has been the single biggest lifesaver, other interventions have helped reduce people's cancer risk. One of the biggest successes is the HPV vaccine. A study last year found that death rates of cervical cancer — which can be caused by HPV infections — in US women ages 20-39 had dropped 62 percent from 2012 to 2021, thanks largely to the spread of the vaccine. Other cancers have been linked to infections, and there is strong research indicating that vaccination can have positive effects on reducing cancer incidence.

The next revolution is better and earlier screening. It's generally true that the earlier cancer is caught, the better the chances of survival... According to one study, incidences of late-stage colorectal cancer in Americans over 50 declined by a third between 2000 and 2010 in large part because rates of colonoscopies almost tripled in that same time period. And newer screening methods, often employing AI or using blood-based tests, could make preliminary screening simpler, less invasive and therefore more readily available. If 20th-century screening was about finding physical evidence of something wrong — the lump in the breast — 21st-century screening aims to find cancer before symptoms even arise.

Most exciting of all are frontier developments in treating cancer... From drugs like lenalidomide and bortezomib in the 2000s, which helped double median myeloma survival, to the spread of monoclonal antibodies, real breakthroughs in treatments have meaningfully extended people's lives — not just by months, but years. Perhaps the most promising development is CAR-T therapy, a form of immunotherapy. Rather than attempting to kill the cancer directly, immunotherapies turn a patient's own T-cells into guided missiles. In a recent study of 97 patients with multiple myeloma, many of whom were facing hospice care, a third of those who received CAR-T therapy had no detectable cancer five years later. It was the kind of result that doctors rarely see.
The article begins with some recent quotes from Jon Gluck, who was told after a cancer diagnosis that he had as little as 18 months left to live — 22 years ago...

A new study "adds a whole extra level of detail to our understanding of caffeine's impact on the brain during sleep," reports ScienceAlert: Caffeine was shown to increase brain signal complexity, and shift the brain closer to a state of 'criticality', in tests run by researchers from the University of Montreal in Canada. This criticality refers to the brain being balanced between structure and flexibility, thought to be the most efficient state for processing information, learning, and making decisions. However, this state might prevent restful sleep, the researchers suggest. The caffeine isn't just keeping us alert, but actually changing how the brain is operating. What's more, they found younger adults aged 20 to 27 were more greatly affected in this way...

When it comes to the different reactions across different ages, the researchers suggest that changes in the brain as we age might be responsible. Adenosine molecules gradually build up in the brain during the day, leading to a greater feeling of fatigue as bedtime approaches. Caffeine works by blocking the receptors that adenosine interacts with, giving us a temporary jolt of energy. Adenosine receptors are more abundant in younger brains, which may explain why younger people seem to be more sensitive to caffeine's powers. That includes both the positive energizing effects, and the negative effects of keeping the brain too active overnight.

"NASA engineers have spent the past decade developing a rugged, partially autonomous lander designed to explore Europa, one of Jupiter's most intriguing moons," reports Gizmodo.

But though NASA "got cold feet over the project," the engineers behind the project are now suggesting the probe could instead explore Enceladus, the sixth-largest moon of Saturn: Europa has long been a prime target in the search for extraterrestrial biology because scientists suspect it harbors a subsurface ocean beneath its icy crust, potentially teeming with microbial life. But the robot — packed with radiation shielding, cutting-edge software, and ice-drilling appendages — won't be going anywhere anytime soon.

In a recent paper in Science Robotics, engineers at NASA's Jet Propulsion Laboratory (JPL) outlined the design and testing of what was once the Europa Lander prototype, a four-legged robotic explorer built to survive the brutal surface conditions of the Jovian moon. The robot was designed to walk — as opposed to roll — analyze terrain, collect samples, and drill into Europa's icy crust — all with minimal guidance from Earth, due to the major communication lag between our planet and the moon 568 million miles (914 million kilometers) away. Designed to operate autonomously for hours at a time, the bot came equipped with stereoscopic cameras, a robotic arm, LED lights, and a suite of specialized materials tough enough to endure harsh radiation and bone-chilling cold....

According to the team, the challenges of getting to Europa — its radiation exposure, immense distance, and short observation windows — proved too daunting for NASA's higher-ups. And that's before you take into consideration the devastating budget cuts planned by the Trump administration, which would see the agency's funding fall from $7.3 billion to $3.9 billion. The lander, once the centerpiece of a bold astrobiology initiative, is now essentially mothballed.

But the engineers aren't giving up. They're now lobbying for the robot to get a second shot — on Enceladus, Saturn's ice-covered moon, which also boasts a subsurface ocean and has proven more favorable for robotic exploration. Enceladus is still frigid, but `has lower radiation and better access windows than Europa.

It's no longer a hypothetical question, writes the Washington Post. "In recent years, scientists have devised powerful genetic tools that may be able to eradicate mosquitoes and other pests once and for all."

But along with the ability to fight malaria, dengue, West Nile virus and other serious diseases, "the development of this technology also raises a profound ethical question: When, if ever, is it okay to intentionally drive a species out of existence...?" When so many wildlife conservationists are trying to save plants and animals from disappearing, the mosquito is one of the few creatures that people argue is actually worthy of extinction. Forget about tigers or bears; it's the tiny mosquito that is the deadliest animal on Earth. The human misery caused by malaria is undeniable. Nearly 600,000 people died of the disease in 2023, according to the World Health Organization, with the majority of cases in Africa... But recently, the Hastings Center for Bioethics, a research institute in New York, and Arizona State University brought together a group of bioethicists to discuss the potential pitfalls of intentionally trying to drive a species to extinction. In a policy paper published in the journal Science last month, the group concluded that "deliberate full extinction might occasionally be acceptable, but only extremely rarely..."

It's unclear how important malaria-carrying mosquitoes are to broader ecosystems. Little research has been done to figure out whether frogs or other animals that eat the insects would be able to find their meals elsewhere. Scientists are hotly debating whether a broader "insect apocalypse" is underway in many parts of the world, which may imperil other creatures that depend on them for food and pollination... Instead, the authors said, geneticists should be able to use gene editing, vaccines and other tools to target not the mosquito itself, but the single-celled Plasmodium parasite that is responsible for malaria. That invisible microorganism — which a mosquito transfers from its saliva to a person's blood when it bites — is the real culprit.
A nonprofit research consortium called Target Malaria has genetically modified mosquitoes in their labs (which get core funding from the Gates Foundation and from Open Philanthropy, backed by Facebook co-founder Dustin Moskovitz and his wife). ), and hopes to deploy them in the wild within five years...

LSD "is used to treat conditions like depression, post-traumatic stress disorder and addiction," notes Science Daily. And now a microbiology student "has found a long sought-after fungus that produces effects similar to the semisynthetic drug..." Morning glory plants live in symbiosis with fungi that produce the same ergot alkaloids the Swiss chemist Albert Hofmann modified when he invented LSD in the late 1930s. Hofmann hypothesized that a fungus in morning glories produced alkaloids similar to those in LSD, but the species remained a mystery...

The researchers dubbed the fungus "Periglandula clandestina" for its ability to have eluded investigators for decades.

MIT comp-sci professor Ryan Williams suspected that a small amount of memory "would be as helpful as a lot of time in all conceivable computations..." writes Quanta magazine.

"In February, he finally posted his proof online, to widespread acclaim..." Every algorithm takes some time to run, and requires some space to store data while it's running. Until now, the only known algorithms for accomplishing certain tasks required an amount of space roughly proportional to their runtime, and researchers had long assumed there's no way to do better. Williams' proof established a mathematical procedure for transforming any algorithm — no matter what it does — into a form that uses much less space.

What's more, this result — a statement about what you can compute given a certain amount of space — also implies a second result, about what you cannot compute in a certain amount of time. This second result isn't surprising in itself: Researchers expected it to be true, but they had no idea how to prove it. Williams' solution, based on his sweeping first result, feels almost cartoonishly excessive, akin to proving a suspected murderer guilty by establishing an ironclad alibi for everyone else on the planet. It could also offer a new way to attack one of the oldest open problems in computer science.

"It's a pretty stunning result, and a massive advance," said Paul Beame, a computer scientist at the University of Washington.
Thanks to long-time Slashdot reader mspohr for sharing the article.

Physicists at Loughborough University have created what they believe is the world's smallest violin, measuring just 35 microns long and 13 microns wide -- smaller than the width of a human hair, which typically ranges from 17 to 180 microns in diameter. The microscopic instrument, created using the university's new nanolithography system, serves as a demonstration of precision manufacturing capabilities that researchers will apply to studies of computing efficiency and energy harvesting methods.

The team used a NanoFrazor machine employing thermal scanning probe lithography, where a heated needle-like tip etches highly precise patterns at the nanoscale onto a chip coated with gel-like resist material. While the individual violin takes roughly three hours to produce, the research team spent several months refining their techniques to achieve the final result, which exists as a microscopic image rather than a playable instrument.

Japan-based Ispace confirmed its Resilience lander likely crashed during its second failed attempt at a lunar landing, after a sensor malfunction prevented proper deceleration. Despite the setback, the company remains committed to future missions, with funding secured for a third attempt using a new lander, Apex 1.0, scheduled for 2027. "Until then, Ispace has its work cut out for it," reports CNN. "[Ispace CEO and founder Takeshi Hakamada] said during the news briefing he will need to work to regain the trust of investors, and the company will need to deeply investigate what went wrong on the Resilience mission to ensure similar issues don't plague Apex 1.0."

The company has ambitious "plans to eventually build a city on the lunar surface that would house a thousand people and welcome thousands more for tourist visits," notes ABC News. "If ispace is going to establish a colony on the moon, it will need to identify an ample supply of ice or water, which it will convert into fuel for a future lunar fueling station. The ability to produce fuel on the moon will enable the company to transport people back and forth between the Earth and the moon."

alternative_right shares a report from Phys.Org: Using conventional propulsion and low-energy trajectories, it takes six to nine months for crewed spacecraft to reach Mars. These durations complicate mission design and technology requirements and raise health and safety concerns since crews will be exposed to extended periods in microgravity and heightened exposure to cosmic radiation. Traditionally, mission designers have recommended nuclear-electric or nuclear-thermal propulsion (NEP/NTP), which could shorten trips to just 3 months. In a recent study, a UCSB physics researcher identified two trajectories that could reduce transits to Mars using the Starship to between 90 and 104 days.

The study was authored by Jack Kingdon, a graduate student researcher in the Physics Department at the University of California, Santa Barbara (UCSB). He is also a member of the UCSB Weld Lab, an experimental ultracold atomic physics group that uses quantum degenerate gases to explore quantum mechanical phenomena. [...] As outlined on its website, conference presentations, and user manual, the SpaceX mission architecture consists of six Starships traveling to Mars. Four of these spacecraft will haul 400 metric tons (440 U.S. tons) of cargo while two will transport 200 passengers. Based on the Block 2 design, which has a 1,500 metric ton (1,650 U.S. ton) propellant capacity, the crewed Starships will require 15 tankers to fully refuel in low Earth orbit (LEO). The cargo ships would require only four, since they would be sent on longer low-energy trajectories. Once the flotilla arrives at Mars, the Starships will refuel using propellant created in situ using local carbon dioxide and water ice. When the return window approaches, one of the crew ships and 3-4 cargo ships will refuel and then launch into a low Mars orbit (LMO). The cargo ships will then transfer the majority of their propellant to the crew ship and return to the surface of Mars. The crew ship would then depart for Earth, and the process could be repeated for the other crew ship.

Kingdon calculated multiple trajectories using a Lambert Solver, which produces the shortest elliptical arc in two-body problem equations (aka Lambert's problem). The first would depart Earth on April 30th, 2033, taking advantage of the 26-month periodic alignment between Earth and Mars. The transit would last 90 days, with the crew returning to Earth after another 90-day transit by July 2nd, 2035. The second would depart Earth on July 15th, 2035, and return to Earth after a 104-day transit on December 5th, 2037. As Kingdon explained, the former trajectory is the most likely to succeed: "The optimal trajectory is the 2033 trajectory -- it has the lowest fuel requirements for the fastest transit time. A note that may not be obvious to the layreader is that Starship can very easily reach Mars in ~3 months -- in fact, it can in any launch window, over a fairly wide range of trajectories. However, Starship may impact the Martian atmosphere too fast (although we do not know, and likely SpaceX don't either actually how fast Starship can hit the Martian atmosphere and survive). The trajectories discussed are ones that I am confident Starship will survive." The paper describing the work has been published in the journal Scientific Reports.

Researchers in Japan have developed a plastic that dissolves in seawater within hours, offering up a potential solution for a modern-day scourge polluting oceans and harming wildlife. From a report: While scientists have long experimented with biodegradable plastics, researchers from the RIKEN Center for Emergent Matter Science and the University of Tokyo say their new material breaks down much more quickly and leaves no residual trace.

At a lab in Wako city near Tokyo, the team demonstrated a small piece of plastic vanishing in a container of salt water after it was stirred up for about an hour. While the team has not yet detailed any plans for commercialisation, project lead Takuzo Aida said their research has attracted significant interest, including from those in the packaging sector.