Biotech

Telegram CEO Durov Fathered Over 100 Kids as an Anonymous Sperm Donor (msn.com) 88

An anonymous reader shared this report from USA Today: He's the founder of Telegram. He was arrested in France. He also claims to have fathered at least 100 children...

The 39-year-old Russian-born billionaire often keeps his personal life out of the spotlight. Something he has shared, however, is that, despite never marrying and preferring to live alone, he's fathered at least 100 children through anonymous sperm donation... Durov noted he plans to "open-source" his DNA so his biological children can find each other more easily. "I also want to help destigmatize the whole notion of sperm donation and incentivize more healthy men to do it, so that families struggling to have kids can enjoy more options," he wrote. "Defy convention — redefine the norm...!"

"Sperm donation has allowed many people to have families who otherwise wouldn't be able to," the article points out. But it also adds that the anonymous practice "has drawn several detractors, including from those who've been conceived through it." These people have shared with USA TODAY the mental turmoil of learning they have, in some cases, hundreds of half-siblings... One of the main criticisms of the practice is that the anonymity of the donor makes it difficult or impossible for donor-conceived people to learn about their health and treat genetically inherited medical issues. Even when donor-conceived people have their donor's identity and contact information, there's still no guarantee they'll respond or tell the truth. Also, most sperm banks in the United States aren't legally required to keep records of siblings or cap the number of families that can use a specific donor. As a result, donor-conceived people with many siblings often live in fear of accidentally having children with one of their half-siblings, or even having children with their own father if they were to pursue donor insemination.
ISS

ESA Prints 3D Metal Shape In Space For First Time (theregister.com) 8

The European Space Agency (ESA) has successfully 3D printed the first metal part aboard the International Space Station. This achievement marks a significant advancement in in-orbit manufacturing that could enable the production of essential spare parts and tools for future long-duration space missions. "The first metal shape was produced in August, and three more are planned as part of the experiment," notes The Register. "All four will eventually be returned to Earth for analysis -- two to ESA's technical center, ESTEC, in the Netherlands, one to the agency's astronaut training center in Cologne, and the last sample to the Technical University of Denmark." From the report: During a panel discussion following the UK premiere of Fortitude, a film about the emerging commercial space industry, Advenit Makaya, Advanced Manufacturing Engineer at ESA, remarked on the potential for recycling space debris in the process rather than having to rely on raw materials launched to the ISS. Rob Postema, ESA Project Manager for Metal 3D, told The Register that the agency was indeed looking at "circular" solutions in its drive for greater sustainability. However, don't hold your breath for putting bits of space garbage into one end and getting shiny metal parts out of the other: "A timeline is difficult to indicate, some early results are achieved with ground activities, ready to evaluate solutions in space."

The printer is overseen from the ground and operated for around four hours per day. The ground team has to check each layer via images and a scan of the surface area; printing a sample can take 10-25 days. However, Postema said: "Through automated control of the printing process as well as continuous operations, this can be substantially reduced." Knick-knacks from orbits are all well and good, but could something more substantial be produced? Yes, although not with this demonstrator, which can print to the outer dimensions of a soft drink can. Postema noted that while the demonstrator could manage smaller parts, either as a single unit or as part of larger structures, "there are definitely opportunities to create 3D shapes and parts with this technology larger than what we have done with this Technology Demonstrator."

ISS

Boeing's Starliner Makes 'Picture Perfect' Landing - Without Its Crew (npr.org) 103

Boeing's "beleaguered" Starliner spacecraft "successfully landed in New Mexico just after midnight Eastern time," reports NPR: After Starliner made a picture-perfect landing, Stich told reporters that the spacecraft did well during its return flight. "It was a bullseye landing," he said. "It's really great to get the spacecraft back...." He said while he and others on the team felt happy about the successful landing, "there's a piece of us, all of us, that we wish it would've been the way we had planned it" with astronauts on board when it landed...

Now that Starliner is back on the ground, Boeing and NASA will further analyze the thrusters to see if modifying the spacecraft or how it's flown could keep the thrusters from overheating in the future.

Futurism explains why NASA wanted an uncrewed Starliner flight: While attempting to duplicate the issue at NASA's White Sands Test Facility in New Mexico, engineers eventually found what appeared to be the smoking gun, as SpaceNews' Jeff Foust details in a detailed new breakdown of the timeline. A Teflon seal in a valve known as a "poppet" expanded as it was being heated by the nearby thrusters, significantly constraining the flow of the oxidizer — a disturbing finding, because it greatly degraded the thrusters' performance.

Worse, without being able to perfectly replicate and analyze the issue in the near vacuum of space, engineers weren't entirely sure how the issue was actually playing out in orbit... While engineers found that the thrusters had returned to a more regular shape after being fired in space, they were worried that similar deformations might take place during prolonged de-orbit firings.

A lot was on the line. Without perfect control over the thrusters, NASA became worried that the spacecraft could careen out of control. "For me, one of the really important factors is that we just don't know how much we can use the thrusters on the way back home before we encounter a problem," NASA associate administrator for space operations Ken Bowersox said, as quoted by SpaceNews.

Now CBS News reports that "the road ahead is far from clear" for Starliner: The service module was jettisoned as planned before re-entry, burning up in the atmosphere, and engineers will not be able to examine the hardware to pin down exactly what caused the helium leaks and degraded thruster performance during the ship's rendezvous with the station. Instead, they will face more data analysis, tests and potential redesigns expected to delay the next flight, with or without astronauts aboard, to late next year at the earliest.

"Even though it was necessary to return the spacecraft uncrewed, NASA and Boeing learned an incredible amount about Starliner in the most extreme environment possible," Ken Bowersox, space operations director at NASA Headquarters, said in a statement. "NASA looks forward to our continued work with the Boeing team to proceed toward certification of Starliner for crew rotation missions to the space station," Bowersox added. In any case, the successful landing was a shot in the arm for Boeing engineers and managers, who insisted the Starliner could have safely brought Wilmore and Williams back to Earth.

Steve Stich, manager of NASA's commercial crew program, agreed that if the crew had been on board "it would have been a safe, successful landing."

Two details about the astronauts now waiting for their February return flight from the International Space Station.
  • NPR reports that "in case the space station suffers an emergency that forces an evacuation before that capsule arrives, the station's crew had to jerry-rig two extra seats in a different SpaceX spacecraft that's currently docked there."
  • Space.com reports that when the uncrewed Starliner returned, "Among the gear that it carried home were the 'Boeing Blue' spacesuits that Williams and Wilmore wore aboard the capsule. The astronauts have no need for them now. "The suits are not compatible," Steve Stich, manager of NASA's Commercial Crew Program, said during a press conference on Wednesday (Sept. 4). "So the Starliner suits would not work in Dragon, and vice versa."

Earth

Heatwave Across US West Breaks Records For Highest Temperatures (theguardian.com) 73

An intense heatwave across the US west has brought unusually warm temperatures to the region -- some of the highest of the season -- and broken heat records. From a report: Millions of Americans from Phoenix to Los Angeles to Seattle are under heat alerts. Even before this latest bout of extreme weather, which began on Wednesday and is expected to last through the weekend, summer 2024 was already considered the hottest summer on record.

In California, the desert city of Indio saw its hottest 5 September at 121F (49.4C), breaking a previous record of 120 from 2020, while Palm Springs tied its heat record for the day at 121F. The city recorded its all-time high of 124F in July. The Los Angeles region has not yet broken any records -- although Burbank tied for its all-time high of 114F -- the area is bracing for a days-long stretch of triple-digit temperatures. This week Phoenix marked 100 straight days at 100F or more and its hottest 5 September at 116F. In the Pacific north-west, schools around Portland closed early due to the heat and the typically cool Seattle broke its daily temperature record on Thursday at 89F.

This summer was the hottest on record across the world and the Earth saw its hottest day in recorded history on 22 July, which broke a record set the previous day. Heatwaves are growing more frequent, more extreme and longer-lasting in the US west and across the world as the climate crisis drives increasingly severe and dangerous weather conditions. Heatwaves are the weather event most directly affected by the climate crisis, an expert told the Guardian in July.

Medicine

Part of Brain Network Much Bigger In People With Depression, Scientists Find 47

Researchers have discovered that people with depression have an expanded brain network, specifically the frontostriatal salience network, which is 73% larger compared to healthy individuals. "It's taking up more real estate on the brain surface than we see is typical in healthy controls," said Dr Charles Lynch, a co-author of the research, from Weill Cornell Medicine in New York. He added that expansion meant the size of other -- often neighboring -- brain networks were smaller. The Guardian reports: Writing in the journal Nature, Lynch and colleagues report how they used precision functional mapping, a new approach to brain imaging that analyses a host of fMRI (functional MRI) scans from each individual. The team applied this method to 141 people with depression and 37 people without it, enabling them to measure accurately the size of each participant's brain networks. They then took the average size for each group. They found that a part of the brain called the frontostriatal salience network was expanded by 73% on average in participants with depression compared with healthy controls.

These findings were supported by an analysis of single brain scans previously collected from 932 healthy people and 299 with depression. The team said the size of this brain network in people with depression did not change with time, mood or transcranial magnetic stimulation treatment. However, brain signals between different parts of the network became less synchronised when participants had certain symptoms of depression, with these changes also associated with the severity of future symptoms. The team added that an analysis of brain scans from 57 children who went on to develop depression as adolescents revealed this brain network was expanded years before their symptoms developed, while it was also expanded in adults with late onset depression.

The researchers said this suggested an expanded brain network could be a risk factor for developing depression, rather than a consequence of the condition. However, they said it was unclear to what extent this enlarged network was the result of genetics or experiences, and whether the association with depression arose from this expansion or from other brain networks consequently being smaller. The team added that their results could offer a way to explore whether certain people may be at increased risk of developing depression, and could help develop personalised treatments.
Robotics

Engineers Gave a Mushroom a Robot Body and Let It Run Wild (sciencealert.com) 64

An anonymous reader quotes a report from ScienceAlert: Nobody knows what sleeping mushrooms dream of when their vast mycelial networks flicker and pulse with electrochemical responses akin to those of our own brain cells. But given a chance, what might this web of impulses do if granted a moment of freedom? An interdisciplinary team of researchers from Cornell University in the US and the University of Florence in Italy took steps to find out, putting a culture of the edible mushroom species Pleurotus eryngii (also known as the king oyster mushroom) in control of a pair of vehicles, which can twitch and roll across a flat surface. Through a series of experiments, the researchers showed it was possible to use the mushroom's electrophysiological activity as a means of translating environmental cues into directives, which could, in turn, be used to drive a mechanical device's movements. "By growing mycelium into the electronics of a robot, we were able to allow the biohybrid machine to sense and respond to the environment," says senior researcher Rob Shepherd, a materials scientist at Cornell.

By applying algorithms based on the extracellular electrophysiology of P. eryngii mycelia and feeding the output into a microcontroller unit, the researchers used spikes of activity triggered by a stimulus -- in this case, UV light -- to toggle mechanical responses in two different kinds of mobile device. In controlled experiments, the team used the signals from a fungal culture to govern the movements of a five-limbed soft robot and a four-wheeled untethered vehicle. They were able to influence and override the 'natural' impulses produced by the fungi, demonstrating an ability to harness the system's sensory abilities to meet an end goal. "This kind of project is not just about controlling a robot," says Cornell bioroboticist Anand Mishra. "It is also about creating a true connection with the living system. Because once you hear the signal, you also understand what's going on. Maybe that signal is coming from some kind of stresses. So you're seeing the physical response, because those signals we can't visualize, but the robot is making a visualization."
The research has been published in the journal Science Robotics.
Space

Saturn's Rings Will Vanish Temporarily In Six Months (earth.com) 17

"Earth.com has an interesting article about the temporary "disappearance" of Saturn's rings in about six months," writes longtime Slashdot reader YVRGeek. From the report: Come March 2025, Saturn's majestic rings will become virtually invisible to earth-based observers. This phenomenon occurs due to the unique tilt of Saturn's axis, which will position the rings edge-on to our line of sight. [...] Saturn's axial tilt, which is the angle its axis leans compared to its orbit around the Sun, is about 27 degrees. As Saturn moves during its 29.5 year orbit around the Sun, this tilt means different parts of its rings and moons get sunlight at different angles, changing how they look. So, the rings are not really disappearing but rather playing a celestial game of hide and seek. At their reappearance, we can also enjoy an accentuated view of Saturn's moons.
Medicine

The Rise of DIY, Pirated Medicine (404media.co) 295

An anonymous reader quotes a report from 404 Media, written by Jason Koebler: I've been videochatting with Mixael Swan Laufer for about 30 minutes about an exciting discovery when he points out that to date, the best way he's been able to bring attention to his organization is "the old school method of me performing a bunch of federal felonies on stage in front of a bunch of people." I stop him and ask: "In this case, what are the felonies?" "Well, the list is pretty long," he said. Laufer is the chief spokesperson of Four Thieves Vinegar Collective, an anarchist collective that has spent the last few years teaching people how to make DIY versions of expensive pharmaceuticals at a tiny fraction of the cost.

Four Thieves Vinegar Collective call what they do "right to repair for your body." Laufer has become well known for handing out DIY pills and medicines at hacking conferences, which include, for example, courses of the abortion drug misoprostol that can be manufactured for 89 cents (normal cost: $160) and which has become increasingly difficult to obtain in some states following the Supreme Court decision in Dobbs. In our call, Laufer had just explained that Four Thieves' had made some miscalculations as part of its latest project, to create instructions for replicating sofosbuvir (Sovaldi), a miracle drug that cures hepatitis C, which he planned to explain and reveal at the DEF CON hacking conference. Unlike many other drugs that treat viruses, Sovaldi does not suppress hepatitis C, a virus that kills roughly 250,000 people around the world each year. It cures it. [...]

Crucially, unlike other medical freedom organizations, Four Thieves isn't suggesting people treat COVID with Ivermectin, isn't shilling random supplements, and doesn't have any sort of commercial arm at all. Instead, they are helping people to make their own, identical pirated versions of proven and tested pharmaceuticals by taking the precursor ingredients and performing the chemical reactions to make the medication themselves. "We don't invent anything, really," Laufer said. "We take things that are on the shelf and hijack them. We like to take something established, and be like 'This works, but you can't get it.' Well, here's a way to get it." A slide at his talk reads "Isn't this illegal? Yeah. Grow up."
Four Thieves has developed a suite of open-source tools to help achieve its goal. The core tool, Chemhacktica, is a software platform that uses machine learning to map chemical pathways for synthesizing desired molecules. It suggests potential chemical reactions, identifies precursor materials, and checks their availability for purchase.

The other is Microlab, an open-source controlled lab reactor built from affordable, off-the-shelf components costing between $300 and $500. It uses Chemhacktica's suggested pathways to create medications, and detailed instructions for building and operating the Microlab are provided. Additionally, the company developed a drag-and-drop recipe system called Apothecarium that generates executable files for the Microlab, offering step-by-step guidance on producing specific medications.

Laufer told 404 Media: "I am of the firm belief that we are hitting a watershed where economics and morality are coming to a head, like, 'Look: intellectual property law is based off some ideas that came out of 1400s Venice. They're not applicable and they're being abused and people are dying every day because of it, and it's not OK.'"

Further reading: Meet the Anarchists Making Their Own Medicine (Motherboard; 2018)
Math

Are Professional Forecasters Overconfident? (newyorkfed.org) 32

Research by the Federal Reserve Bank of New York, published on Tuesday, indicates that professional economic forecasters tend to overestimate their accuracy in long-term predictions while underestimating their short-term precision.

The study, which analyzed data from the Survey of Professional Forecasters from 1982 to 2022, revealed that for forecasts two to four quarters ahead, actual errors were two to four times greater than the forecasters' estimated uncertainty ranges for both GDP growth and inflation. In contrast, for predictions less than three months out, forecasters typically overestimated potential errors.

The study's author, Marco Del Negro, highlighted significant differences in uncertainty estimates among individual forecasters, suggesting that these findings challenge the rational expectations theory. Del Negro proposed that these discrepancies might stem from an over-reliance on varying models or priors in making longer-term forecasts.
Earth

Northern Lights Imperiled Infrastructure From Power Grids To Satellites (bloomberg.com) 51

An anonymous reader quotes a Bloomberg article, written by Jason Leopold: The aurora borealis, or northern lights, is a colorful display in the night sky that comes from geomagnetic storms in space. When charged particles from the sun smash into the Earth's upper atmosphere, they create bright, kaleidoscopic ribbons of light, typically in polar regions. Really big solar action can interfere with GPS systems and power grids. That's exactly what happened on May 10, when there were three "coronal mass ejections" (my future metal band name) that produced one of the most powerful solar storms in 500 years, hence the dazzling, polychromatic sky visible even from South America. Turns out, the extreme space weather also disrupted life on Earth.

Six days after the northern lights, I filed a Freedom of Information Act request with NOAA. I was curious how the agency reacted to the atmospheric event and whether the public deserved to be concerned. I asked NOAA's Space Weather Prediction Center and National Weather Service for a wide range of records, including emails, photographs, satellite images and threat assessments. A couple of weeks ago, NOAA turned over some interesting documents. The short version is, while we marveled at the light show, scientists were concerned. According to one internal memo, the geomagnetic storm was an "extreme," rare event and if NOAA scientists hadn't been on their game it could have been catastrophic.

A May 14, three-page after action memo disseminated by Clinton Wallace, the director of the Space Weather Prediction Center, described the storm's impact and explained the celestial phenomenon. He said "Solar Cycle 25," a phase of solar sunspot activity that began in December 2019 and continues through 2030, "has been more active than anticipated, with an intense surge in solar activity marking the beginning of May." "A large group of unstable sunspots on the Sun's surface unleashed several powerful solar flares, immediately affecting the Earth's outer atmosphere and causing disruptions in high-frequency (HF) radio communications," he wrote. "This had significant implications for trans-oceanic aviation, which relies heavily on HF radio for communication over long distances."

On May 9, a day before the northern lights extravaganza, staff at the Space Weather Prediction Center "activated" the North American Electric Reliability Corp. hotline to make sure the regulator was prepared. Wallace's memo said NERC gave about 3,000 electric utility companies a six-hour head start to get ready. The space weather officials also advised the Federal Emergency Management Agency and the Department of Homeland Security's Cybersecurity and Infrastructure Security Agency on preparedness. Wallace wrote in his memo that the storm caused "significant disruptions across multiple sectors, including navigation, power grids, aviation, and satellite operations." He also noted that the severity of the geomagnetic storm "underscored the interconnectedness and vulnerability of modern infrastructure to space weather." Although Wallace said the space weather scientists took steps to mitigate any potential disaster, their work "highlighted areas for improvement in preparedness and response." He didn't elaborate.

Science

Mobile Phones Not Linked To Brain Cancer, Biggest Study To Date Finds (theguardian.com) 83

Mobile phones are not linked to brain and head cancers, a comprehensive review of the highest quality evidence available commissioned by the World Health Organization has found. From a report: Led by the Australian Radiation Protection and Nuclear Safety Agency (Arpansa), the systematic review examined more than 5,000 studies from which the most scientifically rigorous were identified and weak studies were excluded. The final analysis included 63 observational studies in humans published between 1994 and 2022, making it "the most comprehensive review to date," the review lead author, associate prof Ken Karipidis, said. "We concluded the evidence does not show a link between mobile phones and brain cancer or other head and neck cancers."

Published on Wednesday, the review focused on cancers of the central nervous system (including brain, meninges, pituitary gland and ear), salivary gland tumours and brain tumours. The review found no overall association between mobile phone use and cancer, no association with prolonged use (if people use their mobile phones for 10 years or more), and no association with the amount of mobile phone use (the number of calls made or the time spent on the phone).

Science

How Do Gold Nuggets Form? Earthquakes May Be the Key (nationalgeographic.com) 44

Scientists have finally solved a long-standing mystery about the geologic process behind these large pieces of gold found in quartz rock. From a report: Gold has always been a hot commodity. But these days, finding a nugget isn't too tricky: Much of the world's gold is mined from natural veins of quartz, a glassy mineral that streaks through large chunks of Earth's squashed-up crust. But the geologic process that put gold nuggets there in the first place was a mystery. Now, a new study published today in Nature Geoscience has come up with a convincing, and surprising, answer: electricity, and earthquakes -- lots of them.

Those nuggets owe their existence to the strange electrical properties of common quartz. When squished or jiggled, the mineral generates electricity. That drags gold particles out of fluid in Earth's crust. The particles crystallize out as grains of gold -- and, over time, with enough electrical stimulation, those grains bloom into nuggets. "If you shake quartz, it makes electricity. If you make electricity, gold comes out," says Christopher Voisey, a geologist at Monash University in Australia and the lead author of the new paper. Earthquakes are the most likely natural source of that shaking, and the team's lab experiments show that earthquakes can make gold nuggets.

The idea that gold nuggets appear because of electricity instead of a more conventional geologic process is, at first, a peculiar thought. But "it makes complete sense," says Thomas Gernon, a geoscientist at the University of Southampton in England and who was not involved with the new work. Quartz veins host a disproportionate number of gold nuggets and their environments experience plenty of earthquakes.

ISS

The Speaker on Boeing's Starliner Spacecraft Has Started Making Strange Noises (arstechnica.com) 104

An anonymous reader shared this report from Ars Technica: On Saturday NASA astronaut Butch Wilmore noticed some strange noises emanating from a speaker inside the Starliner spacecraft.

"I've got a question about Starliner," Wilmore radioed down to Mission Control, at Johnson Space Center in Houston. "There's a strange noise coming through the speaker ... I don't know what's making it." [Ars Technica embeded a clip of the conversation including the rhythmic, sonar-like noise which was shared online by a Michigan-based meteorologist.] Wilmore said he was not sure if there was some oddity in the connection between the station and the spacecraft causing the noise, or something else. He asked the flight controllers in Houston to see if they could listen to the audio inside the spacecraft. A few minutes later, Mission Control radioed back that they were linked via "hardline" to listen to audio inside Starliner, which has now been docked to the International Space Station for nearly three months.

Wilmore, apparently floating in Starliner, then put his microphone up to the speaker inside Starliner. Shortly thereafter, there was an audible pinging that was quite distinctive. "Alright Butch, that one came through," Mission control radioed up to Wilmore. "It was kind of like a pulsing noise, almost like a sonar ping."

"I'll do it one more time, and I'll let y'all scratch your heads and see if you can figure out what's going on," Wilmore replied. The odd, sonar-like audio then repeated itself. "Alright, over to you. Call us if you figure it out."

Biotech

A Simple Blood Test Predicts a Person's Heart Disease Risk 30 Years Out, Study Finds (nbcnews.com) 30

An anonymous Slashdot reader shared this report from NBC News: A new approach to a routine blood test could predict a person's 30-year risk of heart disease, research published Saturday in the New England Journal of Medicine found.

Doctors have long assessed their patients' risk for cardiovascular disease by using a blood test to look at cholesterol levels, focusing particularly on LDL or "bad" cholesterol. But limiting blood testing to just cholesterol misses important — and usually silent — risk factors, experts say... Lead study author Dr. Paul Ridker, director of the Center for Cardiovascular Disease Prevention at Brigham and Women's Hospital in Boston and his team found that in addition to LDL cholesterol, two other markers — a type of fat in the blood called lipoprotein (a), or Lp(a), and an indicator of inflammation — are important predictors of a person's risk of heart attack, stroke and coronary heart disease...

In the study, the researchers analyzed data from nearly 30,000 U.S. women who were part of the Women's Health Study. On average, the women were 55 years old when they enrolled in the years 1992 through 1995. About 13% — roughly 3,600 participants — had either a heart attack or stroke, had surgery to fix a narrowed or blocked artery, or died from heart disease over the 30-year follow-up period... All of the women had blood tests done at the beginning of the study to measure their LDL cholesterol, Lp(a) and C-reactive protein levels, a marker of inflammation in the body. These measurements, individually as well as together, appeared to predict a woman's heart health over the next three decades, the study found.

Women with the highest levels of LDL cholesterol had a 36% higher risk for heart disease compared with those with the lowest levels. The highest levels of Lp(a) indicated a 33% elevated risk, and those with the highest levels of CRP were 70% more at risk for heart disease. When the three were looked at together, women who had the highest levels were 1.5 times more likely to have a stroke and over three times more likely to develop coronary heart disease over the next 30 years compared with women with the lowest levels.

All of the markers have been individually linked to higher risk of heart disease, but "all three represent different biological processes. They tell us why someone is actually at risk," Ridker said.

Space

Does Dark Matter Come From Black Holes Formed Before the Big Bang? (livescience.com) 104

"The Big Bang may not have been the beginning of the universe," writes LiveScience, citing "a theory of cosmology that suggests the universe can 'bounce' between phases of contraction and expansion."

The recent study suggests that dark matter could be composed of black holes formed before the Big Bang, during a transition from the universe's last contraction to the current expansion phase... In the new study, researchers explored a scenario where dark matter consists of primordial black holes formed from density fluctuations that occurred during the universe's last contraction phase, not long before the period of expansion that we observe now. They published their findings in June in the Journal of Cosmology and Astroparticle Physics ... In this "bouncing" cosmology, the universe contracted to a size about 50 orders of magnitude smaller than it is today. After the rebound, photons and other particles were born, marking the Big Bang. Near the rebound, the matter density was so high that small black holes formed from quantum fluctuations in the matter's density, making them viable candidates for dark matter.

"Small primordial black holes can be produced during the very early stages of the universe, and if they are not too small, their decay due to Hawking radiation [a hypothetical phenomenon of black holes emitting particles due to quantum effects] will not be efficient enough to get rid of them, so they would still be around now," Patrick Peter, director of research at the French National Centre for Scientific Research (CNRS), who was not involved in the study, told Live Science in an email. "Weighing more or less the mass of an asteroid, they could contribute to dark matter, or even solve this issue altogether."

The scientists' calculations show that this universe mode's properties, such as the curvature of space and the microwave background, match current observations, supporting their hypothesis.

"If this hypothesis holds, the gravitational waves generated during the black hole formation process might be detectable by future gravitational wave observatories, providing a way to confirm this dark matter generation scenario..."
Medicine

Tech Worker Builds Free AI-Powered Tool For Fighting US Health Insurance Denials (sfstandard.com) 52

The online news site San Francisco Standard profiles an open-source platform "that takes advantage of large language models to help users generate health insurance appeals with AI...

"A Fight Health Insurance user can scan their insurance denial, and the system will craft several appeal letters to choose from and modify." With the slogan "Make your health insurance company cry too," [San Francisco tech worker Holden Karau's site] makes filing appeals faster and easier. A recent study found that Affordable Care Act patients appeal only about 0.1% of rejected claims, and she hopes her platform will encourage more people to fight back...

The "dirty secret" of the insurance industry is that most denials can be successfully appealed, according to Dr. Harley Schultz, a patient advocate in the Bay Area. "Very few people know about the process, and even fewer take advantage of it, because it's rather cumbersome, arcane, and confusing, by design," he said. "But if you fight hard enough and long enough, most denials get overturned...."

While some doctors have turned to artificial intelligence themselves to fight claims, Karau's service puts the power in the hands of patients, who likely have more time and motivation to dedicate to their claims. "In an ideal world, we would have a different system, but we don't live in an ideal world, so what I'm shooting for here is incremental progress and making the world suck a little less," she said.

Karau estimates she's spent about $10,000 building the platform, according to the article, which adds that "it's free for users, though she might eventually charge for added services like faxing appeals."

Thanks to Slashdot reader mirro_dude for sharing the news.
Science

Oceanographers Mapping Underwater Mountain Find Flying Spaghetti Monster (cnn.com) 63

Though the ocean covers about 70% of earth, we humans have only mapped a quarter of its floor to a high resolution, reports CNN. Many of the world's highest mountains aren't visible on land — they rise up thousands of meters from the seafloor. An expedition to the Nazca Ridge, 900 miles off the coast of Chile, has mapped and explored a newly discovered seamount four times taller than the world's tallest building. What's more, the underwater mountain's peaks, crags and ridges are home to coral gardens that host rare deep-dwelling octopuses, squids and creatures known as flying spaghetti monsters, some of which hadn't been well documented before this research.
The undersea mountain is 1.9 miles (3,109 meters) tall, according to another article, which notes that the researchers also used a sonar system to bounce waves to the ocean floor, timing how long they took to reach the surface: The researchers documented a ghostly white Casper octopus, marking the first time this deep-dwelling cephalopod has been seen in the southern Pacific. They also spotted two rare Bathyphysa siphonophores, sometimes known as flying spaghetti monsters for their stringlike appearance. "The (Casper) octopus has never been captured, so it doesn't actually have a scientific name yet," Virmani said. The team also recorded the first footage of a live Promachoteuthis squid, known only from a few collected specimens.
Medicine

Long Covid Knocked a Million Americans Off Their Career Paths (msn.com) 151

The Wall Street Journal reports that long Covid "has pushed around one million Americans out of the labor force, economists estimate." More than 5% of adults in the U.S. have long Covid, and it is most prevalent among Americans in their prime working years. About 3.6 million people reported significantly modifying their activities because of the illness in a recent survey by the Centers for Disease Control and Prevention.

Long Covid is a chronic condition with symptoms lasting at least three months after a Covid infection, according to the CDC. Symptoms include fatigue, changes in memory, shortness of breath and trouble concentrating. Long Covid can make tasks as simple as responding to an email arduous, people with the condition say. They struggle to summon the right word or manage stress. Among its many symptoms is post-exertional malaise, which can worsen after even minor physical or mental activity. "People can't go back to work or have to significantly cut down on the amount of work that they can handle," said Akiko Iwasaki, an immunobiology professor at Yale School of Medicine.

Researchers don't know how long symptoms can last. Few people with long Covid have fully recovered within two years. Patients say their doctors have tried everything from antihistamines to blood thinners to physical therapy to acupuncture. Some people might live with the condition for the rest of their lives, said Dr. Paul Volberding, a professor emeritus at the University of California, San Francisco...

Some people with long Covid, which the federal government has classified as a disability, have stayed in their jobs. Human-resource managers have made accommodations including remote work, flexible hours or modified responsibilities, said Rue Dooley of the Society for Human Resource Management. "It's not going away," he said. "It's going to be one of another 100 conditions that we have to grapple with."

People were more likely to develop long Covid at the start of the pandemic, according to a study published in July in the New England Journal of Medicine. The proliferation of vaccines and changes to the virus have made people infected with Covid less likely to develop long Covid.

Earth

Scientists Detect Invisible Electric Field Around Earth For First Time 21

Scientists have finally detected and measured the ambipolar field, a weak electric field surrounding Earth that was first theorized over 60 years ago. "Any planet with an atmosphere should have an ambipolar field," says astronomer Glyn Collinson of NASA's Goddard Space Flight Center. "Now that we've finally measured it, we can begin learning how it's shaped our planet as well as others over time." ScienceAlert reports: Here's how the ambipolar field was expected to work. Starting at an altitude of around 250 kilometers (155 miles), in a layer of the atmosphere called the ionosphere, extreme ultraviolet and solar radiation ionizes atmospheric atoms, breaking off negatively charged electrons and turning the atom into a positively charged ion. The lighter electrons will try to fly off into space, while the heavier ions will try to sink towards the ground. But the plasma environment will try to maintain charge neutrality, which results in the emergence of an electric field between the electrons and the ions to tether them together. This is called the ambipolar field because it works in both directions, with the ions supplying a downward pull and the electrons an upward one. The result is that the atmosphere is puffed up; the increased altitude allows some ions to escape into space, which is what we see in the polar wind.

This ambipolar field would be incredibly weak, which is why Collinson and his team designed instrumentation to detect it. The Endurance mission, carrying this experiment, was launched in May 2022, reaching an altitude of 768.03 kilometers (477.23 miles) before falling back to Earth with its precious, hard-won data. And it succeeded. It measured a change in electric potential of just 0.55 volts -- but that was all that was needed. "A half a volt is almost nothing -- it's only about as strong as a watch battery," Collinson says. "But that's just the right amount to explain the polar wind." That amount of charge is enough to tug on hydrogen ions with 10.6 times the strength of gravity, launching them into space at the supersonic speeds measured over Earth's poles. Oxygen ions, which are heavier than hydrogen ions, are also lofted higher, increasing the density of the ionosphere at high altitudes by 271 percent, compared to what its density would be without the ambipolar field.
The findings have been published in the journal Nature.
Medicine

FDA Wants Safer Cancer Drugs, But Some Startups Fear Unintended Consequences (wsj.com) 37

For decades drugmakers have taken a more-is-more model when dosing cancer drugs in clinical trials. U.S. regulators want them to reconsider that approach. From a report: Companies with cancer drugs in clinical trials must strike a balance between doses high enough to thwart tumors, but low enough to avoid intolerable side effects. For years, Food and Drug Administration officials have expressed concern that cancer drug doses are often too high, leading to unnecessary side effects.

An FDA program launched in 2021, Project Optimus, requires companies to re-examine how they set doses of cancer treatments. This typically involves larger clinical trials to test doses to find those that optimally balance safety and efficacy. Entrepreneurs support the aim, but some fear the initiative will add time and cost to drug development, putting startups at a further disadvantage to larger competitors. [...] The FDA says it encourages drugmakers to discuss dosing plans with the agency and that new medications can still be brought to patients quickly.

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