Mars

Curiosity Rover Finds Hints of a Carbon Cycle on Ancient Mars (arstechnica.com) 11

Billions of years ago Mars "had a warm, habitable climate with liquid water in lakes and flowing rivers," writes Ars Technica.

But "In order for Mars to be warm enough to host liquid water, there must have been a lot of carbon dioxide in the atmosphere," says Benjamin Tutolo, a researcher at the University of Calgary. "The question we've been asking for at least 30 years was where the record of all this carbon is." Tutolo led a new study of rock samples collected by the Curiosity rover that might have answered this question...

Curiosity rover was called Mars Science Laboratory for a reason. It went to the red planet fitted with a suite of instruments, some of which even the newer Perseverance was lacking. These enabled it to analyze the collected Martian rocks on the spot and beam the results back to Earth. "To get the most bang for the buck, NASA decided to send it to the place on Mars called the Gale Crater, because it was the tallest stack of sediments on the planet," Tutolo says. The central peak of Gale Crater was about 5 kilometers tall, created by the ancient meteorite impact... The idea then was to climb up Mount Sharp and collect samples from later and later geological periods at increasing elevations, tracing the history of habitability and the great drying up of Mars.

On the way, the carbon missed by the satellites was finally found...

It turned out the samples contained roughly between 5 and 10 percent of siderite... The siderite found in the samples was also pure, which Tutolo thinks indicates it has formed through an evaporation process akin to what we see in evaporated lakes on Earth. This, in turn, was the first evidence we've found of the ancient Martian carbon cycle. "Now we have evidence that confirms the models," Tutolo claims. The carbon from the atmosphere was being sequestered in the rocks on Mars just as it is on Earth. The problem was, unlike on Earth, it couldn't get out of these rocks... A large portion of carbon that got trapped in Martian rocks stayed in those rocks forever, thinning out the atmosphere.

"While it's likely the red planet had its own carbon cycle, it was an imperfect one that eventually turned it into the lifeless desert it is today," the article points out.

But the study still doesn't entirely explain what warmed the atmosphere of Mars — or why Martian habitability "was seemingly intermittent and fluctuating".
Space

High School Student Discovers 1.5M New Astronomical Objects by Developing an AI Algorithm (smithsonianmag.com) 21

For combining machine learning with astronomy, high school senior Matteo Paz won $250,000 in the Regeneron Science Talent Search, reports Smithsonian magazine: The young scientist's tool processed 200 billion data entries from NASA's now-retired Near-Earth Object Wide-field Infrared Survey Explorer (NEOWISE) telescope. His model revealed 1.5 million previously unknown potential celestial bodies.... [H]e worked on an A.I. model that sorted through the raw data in search of tiny changes in infrared radiation, which could indicate the presence of variable objects.
Working with a mentor at the Planet Finder Academy at Caltech, Paz eventually flagged 1.5 million potential new objects, accoridng to the article, including supernovas and black holes.

And that mentor says other Caltech researchers are using Paz's catalog of potential variable objects to study binary star systems.

Thanks to long-time Slashdot reader schwit1 for sharing the article.
Space

Engineers Want To Bring Home the World's Oldest Satellite (gizmodo.com) 46

Launched in 1958, the "awkward-looking" Vanguard-1 satellite ("the size of a grapefruit") is the oldest artificial object orbiting Earth.

"A team of researchers and engineers want to retrieve the satellite for closer inspection and are currently working to find a way to bring Vanguard-1 home," writes Gizmodo: Other satellites of its time have reentered through Earth's atmosphere, burning up in a fiery death, but Vanguard-1 is still in orbit, silently zooming through the void of space... A team of researchers and engineers from Virginia-based consulting firm Booz Allen Hamilton have put together a proposal on how to retrieve the satellite from space, bringing it back to Earth to study how its equipment has fared over the years, according to a report by Space.com. The team's proposal is detailed in a study published in the Aerospace Research Center earlier this year...

Considering how old Vanguard-1 is, the astronauts would need to handle it with care, according to the team behind the proposal. Before a retrieval attempt, the team suggests that a spacecraft be sent to rendezvous with the satellite to inspect its condition up-close. The engineers suggested partnering with a wealthy space enthusiast willing to fund the outer space venture, or using a SpaceX vehicle to bring the satellite home. Once it's brought back to Earth, experts would examine Vanguard-1 to assess its condition — whether it was struck by space debris, if it's still holding together, and how its time in orbit has affected the satellite. The satellite could then be placed at the Smithsonian for display as a sort of time capsule, a reminder of the history of spaceflight, the team suggests.

"Future missions (space debris removal, materials capture for on-orbit manufacturing, and even deep space exploration) could build on techniques demonstrated in the retrieval of Vanguard 1," the paper read. "Retrieving Vanguard 1 would be a challenge, but an achievable and invaluable step forward for the entire U.S. space community."

"The researchers suggest that the satellite can be placed in a lower orbit and snagged from space, or reeled into the International Space Station," according to the article.

Space.com shares this assessment from Bill Raynor, the associate superintendent of the Naval Research Laboratory's spacecraft engineering division. "For material and radiation effects scientists and engineers, it would be an unprecedented opportunity for investigating the effects of long-term space environmental exposure."

Thanks to long-time Slashdot reader AmiMoJo for sharing the news.
Science

Scientists Claim To Have Found Color No One Has Seen Before (theguardian.com) 80

Researchers at UC Berkeley claim to have induced a previously unseen color by using lasers to stimulate only the M cones in the retina, creating a visual experience beyond the natural limits of human perception. Called olo, the color is described as a highly saturated blue-green but is only visible through direct retinal manipulation. The Guardian reports: "We predicted from the beginning that it would look like an unprecedented color signal but we didn't know what the brain would do with it," said Ren Ng, an electrical engineer at the University of California, Berkeley. "It was jaw-dropping. It's incredibly saturated."

The researchers shared an image of a turquoise square to give a sense of the color, which they named olo, but stressed that the hue could only be experienced through laser manipulation of the retina. "There is no way to convey that color in an article or on a monitor," said Austin Roorda, a vision scientist on the team. "The whole point is that this is not the color we see, it's just not. The color we see is a version of it, but it absolutely pales by comparison with the experience of olo."
The findings have been published in the journal Science Advances.
Music

A Musician's Brain Matter Is Still Making Music Three Years After His Death (popularmechanics.com) 29

An anonymous reader quotes a report from Popular Mechanics: American composer Alvin Lucier was well-known for his experimental works that tested the boundaries of music and art. A longtime professor at Wesleyan University (before retiring in 2011), Alvin passed away in 2021 at the age of 90. However, that wasn't the end of his lifelong musical odyssey. Earlier this month, at the Art Gallery of Western Australia, a new art installation titled Revivification used Lucier's "brain matter" -- hooked up to an electrode mesh connected to twenty large brass plates -- to create electrical signals that triggered a mallet to strike the varying plates, creating a kind of post-mortem musical piece. Conceptualized in collaboration with Lucier himself before his death, the artists solicited the help of researchers from Harvard Medical School, who grew a mini-brain from Lucier's white blood cells. The team created stem cells from these white blood cells, and due to their pluripotency, the cells developed into cerebral organoids somewhat similar to developing human brains. "At a time when generative AI is calling into question human agency, this project explores the challenges of locating creativity and artistic originality," the team behind Revivification told The Art Newspaper. "Revivification is an attempt to shine light on the sometimes dark possibilities of extending a person's presence beyond the seemed finality of death."

"The central question we want people to ask is: could there be a filament of memory that persists through this biological transformation? Can Lucier's creative essence persist beyond his death?" the team said.
Science

Toothpaste Widely Contaminated With Lead and Other Metals, US Research Finds (theguardian.com) 130

Bruce66423 shares a report: Toothpaste can be widely contaminated with lead and other dangerous heavy metals, new research shows.

Most of 51 brands of toothpaste tested for lead contained the dangerous heavy metal, including those for children or those marketed as green. The testing, conducted by Lead Safe Mama, also found concerning levels of highly toxic arsenic, mercury and cadmium in many brands.

About 90% of toothpastes contained lead, 65% contained arsenic, just under half contained mercury, and one-third had cadmium. Many brands contain a number of the toxins. The highest levels detected violated the state of Washington's limits, but not federal limits. The thresholds have been roundly criticized by public health advocates for not being protective -- no level of exposure to lead is safe, the federal government has found.
Bruce66423 asks: "As ever the question that should be asked is: 'What level is worth worrying about and why?'"
Science

The Most-Cited Papers of the Twenty-First Century (nature.com) 13

Nature has published an analysis of the 21st century's most-cited scientific papers, revealing a surprising pattern: breakthrough discoveries like mRNA vaccines, CRISPR, and gravitational waves don't make the list. Instead, a 2016 Microsoft paper on "deep residual learning" networks claims the top spot, with citations ranging from 103,756 to 254,074 depending on the database.

The list overwhelmingly features methodology papers and software tools rather than groundbreaking discoveries. AI research dominates with four papers in the top ten, including Google's 2017 "Attention is all you need" paper that underpins modern language models.

The second-most-cited paper -- a 2001 guide for analyzing gene expression data -- was explicitly created to be cited after journal reviewers rejected references to a technical manual. As sociologist Misha Teplitskiy noted, "Scientists say they value methods, theory and empirical discoveries, but in practice the methods get cited more."
Science

A New Journal Record: Sage Title Retracts 678 More Papers, Tally Over 1,500 23

Sage has retracted 678 more papers from the Journal of Intelligent and Fuzzy Systems (JIFS), concluding an investigation that has now purged 1,561 articles -- the most ever removed from a single journal. The publisher, which acquired JIFS from IOS Press in November 2023, began investigating the journal in early 2024 after discovering "indicators that raised concerns about the authenticity of the research and the peer review process."

This final batch follows 467 articles retracted in August and another 416 in January. Problems in the retracted papers included citation manipulation, "tortured phrases," unauthorized third-party involvement in submissions, and evidence suggesting collusion between authors and reviewers. Most authors were from India and China, with some from Pakistan, Turkey, Iran, and Iraq. Cengiz Kahraman of Istanbul Technical University, who authored 20 of the retracted papers, disputed the decision, telling Retraction Watch that Sage acted "without any reason and evidence." The journal has now resumed publishing.
Moon

ESA Video Game Trains AI To Recognize Craters On the Moon 4

Longtime Slashdot reader Qbertino writes: German public news outlet Tagesschau reports (source: YouTube) on an ESA video game that helps train a future moon lander's guidance AI to spot craters. Games have already helped collect visual data on millions of craters. The University Darmstadt developed the game, called IMPACT, to support ESA's efforts to establish a base on the moon. An older article from August 2024 provides further details on the project.
Space

Astronomers Detect a Possible Signature of Life on a Distant Planet 56

Astronomers have detected what may be the strongest evidence yet of extraterrestrial life on K2-18b, a massive exoplanet orbiting a star 120 light-years from Earth. The research team, led by Cambridge astronomer Nikku Madhusudhan, published their findings today in the Astrophysical Journal Letters.

Using the James Webb Space Telescope, researchers found significant concentrations of dimethyl sulfide and dimethyl disulfide in K2-18b's atmosphere. On Earth, these sulfur compounds are exclusively produced by living organisms, particularly marine algae. "It is in no one's interest to claim prematurely that we have detected life," said Madhusudhan, though he described the findings as "a revolutionary moment" and "the first time humanity has seen potential biosignatures on a habitable planet."

The team detected the signals during two separate observations, with the second showing an even stronger signature. Their analysis suggests K2-18b may be a "Hycean" planet -- covered with warm oceans and wrapped in a hydrogen-rich atmosphere -- with concentrations of dimethyl sulfide thousands of times higher than Earth levels.

Other scientists remain cautious. Christopher Glein of the Southwest Research Institute suggested K2-18b could instead be "a massive hunk of rock with a magma ocean and a thick, scorching hydrogen atmosphere." Further observations with Webb and future NASA telescopes will be necessary to confirm whether K2-18b is truly habitable or inhabited, though planned budget cuts may impact follow-up research.

Further reading: Water Found On a Potentially Life-Friendly Alien Planet (2019).
Science

'We Are Not Programmed to Die,' Says Nobel Laureate Venki Ramakrishnan (wired.com) 86

In a recent interview with Wired, Nobel laureate Venkatraman Ramakrishnan discusses his book Why We Die, in which he argues that death is not genetically programmed but rather a consequence of evolution favoring reproduction over longevity. Here are some of the most thought-provoking excerpts: WIRED: Professor Ramakrishnan, the crucial question in your book is why we die. But exactly what is death?
Venki Ramakrishnan: By death, we mean the irreversible loss of the ability to function as a coherent individual. It is the result of the failure of a critical system or apparatus, for example, heart, brain, lung, or kidney failure. In this sense there is an apparent paradox: When our organism, as a whole, is alive, millions of cells within us are constantly dying, and we do not even realize it. On the other hand, at the time of death, most of the cells in our bodies are still alive, and entire organs are still functioning and can be donated to people in need of transplantation. But at that point the body has lost the ability to function as a whole. In this sense, it is therefore important to distinguish between cell death and death of the individual.

Speaking of death and aging, you say in your most recent book that you "wanted to offer an objective look at our current understanding of the two phenomena." What was the biggest surprise or most deeply held belief that you had to reconsider while writing and researching this work?
There have been several surprises, actually. One is that death, contrary to what one might think, is not programmed by our genes. Evolution does not care how long we live, but merely selects the ability to pass on our genes, a process known as "fitness" in evolutionary biology. Thus, the traits that are selected are those that help us survive childhood and reproduce. And it is these traits, later in life, that cause aging and decline. Another curious finding was the fact that aging is not simply due to wear and tear on cells. Wear and tear happens constantly in all living things, yet different species have very different lifespans. Instead, lifespan is the result of a balance between the expenditure of resources needed to keep the organism functioning and repairing it and those needed to make it grow, mature, and keep it healthy until it reproduces and nurtures offspring.

Do you think there is an aspect of the biology of aging that is still deeply misunderstood by the general public?
Certainly the indefinite extension of life. Although in principle there are no laws or constraints that prevent us from living much longer than we do currently, great longevity or "eternal youth" are still far off, and very significant obstacles to increasing our maximum life expectancy remain. We must also beware of the pseudoscience -- and business -- around the concepts of "anti-aging" or the "reversal of aging." These are often baseless concepts, unsupported by hard evidence, even though they may use language that sounds scientific. Unfortunately, we are all afraid of growing old and dying, so we are very sensitive to any claim that promises to help us avoid it. [...]

What do you think are the social and ethical implications of our desire to live longer?
Ever since we became aware of our mortality, we have desired to defeat aging and death. However, our individual desires may conflict with what is best for society. A society in which fertility rates are very low and lifespans are very high will be a stagnant society, with very slow generational turnover, and probably much less dynamic and creative. The Nobel Prize-winning South American novelist Mario Vargas Llosa, who recently passed away, expressed it best: "Old age on the one hand terrifies us, but when we feel anxious, it is important to remember how terrible it would be to live forever. If eternity were guaranteed, all the incentives and illusions of life would vanish. This thought can help us live old age in a better way."

Robotics

Harvard's RoboBee Masters Landing, Paving Way For Agricultural Pollination (chosun.com) 31

After more than a decade of development, Harvard's insect-sized flying robot, RoboBee, has successfully learned to land using dragonfly-inspired legs and improved flight controls. The researchers see RoboBee as a potential substitute for endangered bees, assisting in the pollination of plants. From a report: RoboBee is a micro flying robot that Harvard has been developing since 2013. As the name suggests, it is the size of a bee, capable of flying like a bee and hovering in mid-air. Its wings are 3 cm long and it weighs only 0.08 g. The weight was reduced by using light piezoelectric elements instead of motors. Piezoelectric elements change shape when an electric current flows through them. The researchers were able to make RoboBee flap its wings 120 times per second by turning the current on and off, which is similar to actual insects.

While RoboBee exhibited flight capabilities comparable to those of a bee, the real problem was landing. Being too light and having short wings, it could not withstand the air turbulence generated during landing. It is easy to understand if you think about the strong winds generated when a helicopter approaches the ground. Christian Chan, a graduate student at Harvard who participated in the research, said, "Until now, it was a matter of shutting off the robot while it attempted to land and praying for a proper touchdown."

To ensure RoboBee's safe landing, it was important to dissipate energy just before touchdown. Hyun Nak-Seung, a professor at Purdue University who participated in the development of RoboBee, explained, "For any flying object, the success of landing depends on minimizing speed just before impact and rapidly dissipating energy afterward. Even for tiny flapping like RoboBee's, the ground effect cannot be ignored, and after landing, the risk of bouncing or rolling makes the situation more complex."
The findings have been published in the journal Science Robotics.
Science

Researchers Grow Record-sized Lab Meat (nature.com) 69

Researchers at the University of Tokyo have created what they believe is the largest single piece of lab-grown meat to date: a chicken nugget-sized chunk measuring 7 centimeters long, 4 centimeters wide, and 2.25 centimeters thick, weighing 11 grams. The breakthrough, reported today in Trends in Biotechnology, uses an artificial circulatory system to overcome a fundamental limitation in cultured meat production.

The team, led by biohybrid system engineer Shoji Takeuchi, grew cells around a network of semipermeable hollow fibers -- similar to those used in water filters and dialysis machines -- that deliver nutrients and oxygen throughout the tissue. Unlike most commercial approaches that produce tiny meat fragments later assembled with binders or scaffolds, this method creates a single coherent piece with more natural structure and texture.

This is the first working model using tubes to grow muscle tissue into a thick slab, according to Mark Post, chief science officer at Mosa Meat, who created the world's first lab-grown hamburger in 2013. Significant hurdles remain before commercialization. The hollow fibers aren't edible and must be manually removed. Researchers are exploring automating this process or creating edible alternatives using cellulose.
Science

First Global Pandemic Treaty Agreed - Without the US (nature.com) 139

For the first time -- and despite fears that it might never happen -- nations have agreed a series of measures to prevent, prepare for and respond to pandemics. Nature: The terms of the first global pandemic accord were still being hashed out at the World Health Organization (WHO) headquarters in Geneva, Switzerland, up until the early hours of 16 April. "This is a definitive moment in the history of global health," says Lawrence Gostin, a specialist in health law and policy at Georgetown University in Washington DC, who followed the negotiations closely. The accord "sets out some very important norms to keep the world safe," he says.

The accord was agreed without the United States, which withdrew from the pandemic treaty the day that President Trump was inaugurated. This reduces its power, says Gostin, but is also a source of strength. "Instead of collapsing in the face of President Trump's assault on global health, the world came together." The treaty is not perfect but represents a major achievement, says Michelle Childs, policy advocacy director at the non-profit organization Drugs for Neglected Diseases Initiative in Geneva. "People didn't think that they'd get to this stage of agreeing at all."

Cellphones

Older People Who Use Smartphones 'Have Lower Rates of Cognitive Decline' (theguardian.com) 52

An anonymous reader quotes a report from The Guardian: Fears that smartphones, tablets and other devices could drive dementia in later life have been challenged by research that found lower rates of cognitive decline in older people who used the technology. An analysis of published studies that looked at technology use and mental skills in more than 400,000 older adults found that over-50s who routinely used digital devices had lower rates of cognitive decline than those who used them less. It is unclear whether the technology staves off mental decline, or whether people with better cognitive skills simply use them more, but the scientists say the findings question the claim that screen time drives what has been called "digital dementia".

"For the first generation that was exposed to digital tools, their use is associated with better cognitive functioning," said Dr Jared Benge, a clinical neuropsychologist in UT Health Austin's Comprehensive Memory Center. "This is a more hopeful message than one might expect given concerns about brain rot, brain drain, and digital dementia." Benge and his colleague Dr Michael Scullin, a cognitive neuroscientist at Baylor University in Texas, analysed 57 published studies that examined the use of digital technology in 411,430 adults around the world. The average age was 69 years old and all had a cognitive test or diagnosis. The scientists found no evidence for the digital dementia hypothesis, which suggests that a lifetime of using digital technology drives mental decline. Rather, they found that using a computer, smartphone, the internet or some combination of these was associated with a lower risk of cognitive impairment. The details have been published in Nature Human Behaviour.
"Using digital devices in the way that we use televisions -- passive and sedentary, both physically and mentally -- is not likely to be beneficial," said Scullin. "But, our computers and smartphones also can be mentally stimulating, afford social connections, and provide compensation for cognitive abilities that are declining with ageing. These latter types of uses have long been regarded as beneficial for cognitive ageing."
Bitcoin

Canadian Math Prodigy Allegedly Stole $65 Million In Crypto (theglobeandmail.com) 85

A Canadian math prodigy is accused of stealing over $65 million through complex exploits on decentralized finance platforms and is currently a fugitive from U.S. authorities. Despite facing criminal charges for fraud and money laundering, he has evaded capture by moving internationally, embracing the controversial "Code is Law" philosophy, and maintaining that his actions were legal under the platforms' open-source rules. The Globe and Mail reports: Andean Medjedovic was 18 years old when he made a decision that would irrevocably alter the course of his life. In the fall of 2021, shortly after completing a master's degree at the University of Waterloo, the math prodigy and cryptocurrency trader from Hamilton had conducted a complex series of transactions designed to exploit a vulnerability in the code of a decentralized finance platform. The maneuver had allegedly allowed him to siphon approximately $16.5-million in digital tokens out of two liquidity pools operated by the platform, Indexed Finance, according to a U.S. court document.

Indexed Finance's leaders traced the attack back to Mr. Medjedovic, and made him an offer: Return 90 per cent of the funds, keep the rest as a so-called "bug bounty" -- a reward for having identified an error in the code -- and all would be forgiven. Mr. Medjedovic would then be free to launch his career as a white hat, or ethical, hacker. Mr. Medjedovic didn't take the deal. His social media posts hinted, without overtly stating, that he believed that because he had operated within the confines of the code, he was entitled to the funds -- a controversial philosophy in the world of decentralized finance known as "Code is Law." But instead of testing that argument in court, Mr. Medjedovic went into hiding. By the time authorities arrived on a quiet residential street in Hamilton to search his parents' townhouse less than two months later, Mr. Medjedovic had moved out, taking his electronic devices with him.

Then, roughly two years later, he struck again, netting an even larger sum -- approximately $48.4-million -- by conducting a similar exploit on another decentralized finance platform, U.S. authorities allege. Mr. Medjedovic, now 22, faces five criminal charges -- including wire fraud, attempted extortion and money laundering -- according to a U.S. federal court document that was unsealed earlier this year. If convicted, he could be facing decades in prison. First, authorities will have to find him.

Medicine

CT Scans Projected to Result in 100,000 New Cancers in The US 68

A new study projects that CT scans conducted in 2023 may result in around 103,000 future cancer cases in the U.S. due to low-dose ionizing radiation. "[I]t would put CT scans on par with other significant risk factors for cancer, like alcohol consumption, at least at a population level," reports ScienceAlert. From the report: At an individual level, the theoretical chance of developing cancer from a CT scan is thought to be very minimal, if it exists at all, and patients should not be scared of undergoing these tests if they are deemed medically necessary. However, the number of CT examinations performed each year in the US has increased by more than 30 percent since 2007, and researchers suggest that unwarranted tests are exposing the population to unnecessary radiation. [...]

The anonymous data comes from 143 hospitals and outpatient facilities across the US, catalogued in the UCSF International CT Dose Registry. Using statistics from 2016 to 2022, researchers predicted 93 million CT examinations were carried out in 2023, on roughly 62 million patients. Based on the associated radiation risks, the team estimates that CT scans in 2023 may be tied to 103,000 future cancers.
The findings have been published in JAMA Internal Medicine.
Space

Blue Origin Sends All-Female Crew To Edge of Space in Historic Flight (npr.org) 132

Blue Origin's New Shepard completed its 31st mission Monday morning, carrying the first all-female crew to space since Soviet cosmonaut Valentina Tereshkova's 1963 solo flight. The NS-31 mission lifted off from West Texas at 9:30 a.m. EDT, with hundreds of thousands watching via livestream as the autonomous vehicle crossed the Karman line 62 miles above Earth.

The 10-minute suborbital journey carried six passengers: journalist and Bezos' fiancee Lauren SÃnchez, former NASA scientist Aisha Bowe, bioastronautics researcher Amanda Nguyen, CBS journalist Gayle King, pop star Katy Perry, and film producer Kerianne Flynn. Bowe conducted three research experiments during the flight, while Nguyen became the first Vietnamese and Southeast Asian woman in space. The fully reusable New Shepard system features a pressurized capsule that separates from its booster before returning to Earth with three parachutes.
Medicine

Three Million Child Deaths Linked To Drug Resistance, Study Shows (bbc.co.uk) 36

"More than three million children around the world are thought to have died in 2022 as a result of infections that are resistant to antibiotics," reports the BBC, citing a study by two leading experts in child health that used data from sources including the World Health Organization and the World Bank: Experts say this new study highlights a more than tenfold increase in AMR-related infections in children in just three years. The number could have been made worse by the impact of the Covid pandemic...

The report's lead authors, Doctor Yanhong Jessika Hu of Murdoch Children's Research Institute in Australia and Professor Herb Harwell of the Clinton Health Access Initiative, point to a significant growth in the use of antibiotics that are meant to only be held back for the most serious infections. Between 2019 and 2021 the use of "watch antibiotics", drugs with a high risk of resistance, increased by 160% in South East Asia and 126% in Africa. Over the same period, "reserve antibiotics" — last-resort treatments for severe, multidrug-resistant infections — rose by 45% in South East Asia and 125% in Africa.

The authors warn that if bacteria develop resistance to these antibiotics, there will be few, if any, alternatives for treating multidrug-resistant infections.

"Antibiotics are ubiquitous around us," Professor Harwell warns in the article. "They end up in our food and the environment and so coming up with a single solution is not easy." The article also quotes a senior lecturer in microbiology at King's College London, who says the new study "marks a significant and alarming increase compared to previous data".

"These findings should serve as a wake-up call for global health leaders. Without decisive action, AMR could undermine decades of progress in child health, particularly in the world's most vulnerable regions."

Thanks to Slashdot reader Bruce66423 for sharing the article.
Math

How a Secretive Gambler Called 'The Joker' Beat the Texas Lottery (msn.com) 113

"Can you help me take down the Texas lottery?"

That's what a London banker-turned-bookmaker asked "acquaintances" in 2023, reports the Wall Street Journal. The plan was to buy "nearly every possible number in a coming drawing" — purchasing $1 tickets for 25.8 million possible combinations, since "The jackpot was heading to $95 million. If nobody else also picked the winning numbers, the profit would be nearly $60 million." Marantelli flew to the U.S. with a few trusted lieutenants. They set up shop in a defunct dentist's office, a warehouse and two other spots in Texas. The crew worked out a way to get official ticket-printing terminals. Trucks hauled in dozens of them and reams of paper... [Then Texas announced no winner in an earlier lottery, rolling its jackpot into another drawing three days later.] The machines — manned by a disparate bunch of associates and some of their children — screeched away nearly around the clock, spitting out 100 or more tickets every second. Texas politicians later likened the operation to a sweatshop.

Trying to pull off the gambit required deep pockets and a knack for staying under the radar — both hallmarks of the secretive Tasmanian gambler who bankrolled the operation. Born Zeljko Ranogajec, he was nicknamed "the Joker" for his ability to pull off capers at far-flung casinos and racetracks. Adding to his mystique, he changed his name to John Wilson several decades ago. Among some associates, though, he still goes by Zeljko, or Z. Over the years, Ranogajec and his partners have won hundreds of millions of dollars by applying Wall Street-style analytics to betting opportunities around the world. Like card counters at a blackjack table, they use data and math to hunt for situations ripe for flipping the house edge in their favor. Then they throw piles of money at it, betting an estimated $10 billion annually.

The Texas lottery play, one of their most ambitious operations ever, paid off spectacularly with a $57.8 million jackpot win. That, in turn, spilled their activities into public view and sparked a Texas-size uproar about whether other lotto players — and indeed the entire state — had been hoodwinked. Early this month, the state's lieutenant governor, Dan Patrick, called the crew's win "the biggest theft from the people of Texas in the history of Texas." In response to written questions addressed to Marantelli and Ranogajec, Glenn Gelband, a New Jersey lawyer who represents the limited partnership that claimed the Texas prize, said "all applicable laws, rules and regulations were followed...."

Lottery officials and state lawmakers have taken steps to prevent a repeat.

The article also looks at a group of Princeton University graduates calling themselves Black Swan Capital that's "won millions in recent years" by targetting state lottery drawings with unusually favorable odds.

"State lottery directors say they are seeing more organized efforts to buy lottery tickets in bulk," according to the article, "but that the groups are largely operating legally and transparently..."

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