The James Webb Space Telescope has discovered the most distant galaxy ever observed, named MoM z14. NASA estimates it existed just 280 million years after the Big Bang. Space.com reports: Prior to the discovery of MoM z14, the galaxy holding the title of earliest and distant was JADES-GS-z14-0, which existed just 300 million years after the Big Bang, or around 13.5 billion years ago. This previous record galaxy has a redshift of z =14.32, while MoM z14 has a redshift of z = 14.44. There is a wider context to the observation of MoM z14 than the fact that it has broken the record for earliest known galaxy by 20 million years, though, as [explained team member and Yale University professor of Astronomy and Physics Pieter van Dokkum].

The researchers were able to determine that MoM z14 is around 50 times smaller than the Milky Way. The team also measured emission lines from the galaxy, indicating the presence of elements like nitrogen and carbon. "The emission lines are unusual; it indicates that the galaxy is very young, with a rapidly increasing rate of forming new stars," van Dokkum said. "There are also indications that there is not much neutral hydrogen gas surrounding the galaxy, which would be surprising: the very early universe is expected to be filled with neutral hydrogen. "That needs even better spectra and more galaxies, to investigate more fully."

The presence of carbon and nitrogen in MoM z14 indicates that there are earlier galaxies to be discovered than this 13.52 billion-year-old example. That is because the very earliest galaxies in the universe and their stars were filled with the simplest elements in the cosmos, hydrogen and helium. Later galaxies would be populated by these heavier elements, which astronomers somewhat confusingly call "metal," as their stars forged them and then dispersed them in supernova explosions. The research has been published on arXiv.

An anonymous reader quotes a report from IEEE Spectrum: In a development straight out of science fiction, Australian startup Cortical Labs has released what it calls the world's first code-deployable biological computer. The CL1, which debuted in March, fuses human brain cells on a silicon chip to process information via sub-millisecond electrical feedback loops. Designed as a tool for neuroscience and biotech research, the CL1 offers a new way to study how brain cells process and react to stimuli. Unlike conventional silicon-based systems, the hybrid platform uses live human neurons capable of adapting, learning, and responding to external inputs in real time. "On one view, [the CL1] could be regarded as the first commercially available biomimetic computer, the ultimate in neuromorphic computing that uses real neurons," says theoretical neuroscientist Karl Friston of University College London. "However, the real gift of this technology is not to computer science. Rather, it's an enabling technology that allows scientists to perform experiments on a little synthetic brain."

The first 115 units will begin shipping this summer at $35,000 each, or $20,000 when purchased in 30-unit server racks. Cortical Labs also offers a cloud-based "wetware-as-a-service" at $300 weekly per unit, unlocking remote access to its in-house cell cultures. Each CL1 contains 800,000 lab-grown human neurons, reprogrammed from the skin or blood samples of real adult donors. The cells remain viable for up to six months, fed by a life-support system that supplies nutrients, controls temperature, filters waste, and maintains fluid balance. Meanwhile, the neurons are firing and interpreting signals, adapting from each interaction.

The CL1's compact energy and hardware footprint could make it attractive for extended experiments. A rack of CL1 units consumes 850-1,000 watts, notably lower than the tens of kilowatts required by a data center setup running AI workloads. "Brain cells generate small electrical pulses to communicate to a broader network," says Cortical Labs Chief Scientific Officer Brett Kagan. "We can do something similar by inputting small electrical pulses representing bits of information, and then reading their responses. The CL1 does this in real time using simple code abstracted through multiple interacting layers of firmware and hardware. Sub-millisecond loops read information, act on it, and write new information into the cell culture." The company sees CL1 as foundational for testing neuropsychiatric treatments, leveraging living cells to explore genetic and functional differences. "It allows people to study the effects of stimulation, drugs and synthetic lesions on how neuronal circuits learn and respond in a closed-loop setup, when the neuronal network is in reciprocal exchange with some simulated world," says theoretical neuroscientist Karl Friston of University College London. "In short, experimentalists now have at hand a little 'brain in a vat,' something philosophers have been dreaming about for decades."

Live-animal markets across Southeast Asia continue operating as natural laboratories for deadly pathogens despite warnings from public health experts about their role in disease transmission, according to new research published in Nature.

Scientists studying markets like Jakarta's Jatinegara found that coronavirus detection rates in trafficked animals increase dramatically along supply chains, with rats sold at Vietnamese markets testing positive at rates ten times higher than those caught in fields. Pangolins confiscated in Vietnam showed a seven-fold increase in coronavirus infections compared to animals seized earlier in the smuggling process.

The research comes as political headwinds have severely reduced funding for pandemic preparedness, with the Trump administration terminating a $125-million disease monitoring program and cutting all USAID functions. Scientists report growing reluctance from government officials to authorize publication of pathogen discoveries, fearing stigma and trade restrictions, while wildlife traders increasingly avoid participating in studies that could reveal new health risks.

President Trump's 2026 budget proposes over $1 billion for Mars exploration through a new Commercial Mars Payload Services Program, while simultaneously slashing NASA's overall budget by 25%. Phys.Org reports: Under the proposal, NASA would award contracts to companies developing spacesuits, communications systems and a human-rated landing vehicle to foster exploration of the Red Planet. Trump's proposed $18.8 billion NASA budget would cut the agency's funding by about 25% from the year before, with big hits to its science portfolio. The fleshed-out request on Friday builds upon a condensed budget proposal released earlier this month.

"We must continue to be responsible stewards of taxpayer dollars," NASA Acting Administrator Janet Petro wrote in a letter included in the request. "That means making strategic decisions -- including scaling back or discontinuing ineffective efforts." The new Mars scheme is modeled after NASA's Commercial Lunar Payload Services program that has benefited Intuitive Machines LLC, Firefly Aerospace Inc. and Astrobotic Technology Inc., though it has achieved mixed results. According to the budget, the contract to land on Mars would build upon existing lander contracts. America's Next NASA Administrator Will Not Be Former SpaceX Astronaut Jared Isaacman

New simulations suggest that the long-assumed collision between the Milky Way and Andromeda galaxies is not guaranteed, with the odds now estimated at just over 50% within the next 10 billion years. Factoring in other massive galaxies like M33 and the Large Magellanic Cloud revealed that their gravitational influence significantly alters the likelihood of a merger. ScienceAlert reports: The Milky Way and Andromeda are not, however, alone in this little corner of the cosmos. They belong to a small group of galaxies within a radius of about 5 million light-years from the Milky Way known as the Local Group. The Milky Way and Andromeda are the largest members, but there are quite a few other objects hanging out that need to be taken into consideration when modeling the future. [Astrophysicist Till Sawala of the University of Helsinki] and his colleagues took the latest data from the Hubble and Gaia space telescopes, and the most recent mass estimates for the four most massive objects in the Local Group -- the Milky Way, Andromeda, the Triangulum galaxy (M33), and the Large Magellanic Cloud (LMC). Then, they set about running simulations of the next 10 billion years, adding and removing galaxies to see how that changed the results.

Their results showed that the presence of M33 and LMC dramatically altered the probability of a collision between the Milky Way and Andromeda. When it is just the two large spiral galaxies, the merger occurred in slightly less than half the simulation runs. The addition of M33 increased the merger probability to two in three. Taking M33 back out and adding LMC had the opposite effect, decreasing the probability to one in three. When all four galaxies were present, the probability of a merger between the Milky Way and Andromeda within 10 billion years is slightly more than 50 percent. "We find that there are basically two types of outcomes," Sawala said. "The Milky Way and Andromeda will either come close enough on their first encounter (first 'pericenter') that dynamical friction between the two dark matter haloes will drag the orbit to an eventual merger, which very likely happens before 10 billion years, or they do not come close enough, in which case dynamical friction is not effective, and they can still orbit for a very long time thereafter."

"The main result of our work is that there is still significant uncertainty about the future evolution -- and eventual fate -- of our galaxy," Sawala added. "Of course, as a working astrophysicist, the best results are those that motivate future studies, and I think our paper provides motivation both for more comprehensive models and for more precise observations."

The research has been published in Nature Astronomy.

An anonymous reader quotes a report from The Guardian: People born more recently are less likely to have dementia at any given age than earlier generations, research suggests, with the trend more pronounced in women. According to the World Health Organization, in 2021 there were 57 million people worldwide living with dementia, with women disproportionately affected. However, while the risk of dementia increases with age, experts have long stressed it is not not an inevitability of getting older. "Younger generations are less likely to develop dementia at the same age as their parents or grandparents, and that's a hopeful sign," said Dr Sabrina Lenzen, a co-author of the study from the University of Queensland's Centre for the Business and Economics of Health. But she added: "The overall burden of dementia will still grow as populations age, and significant inequalities remain -- especially by gender, education and geography."

Writing in the journal Jama Network Open, researchers in Australia report how they analyzed data from 62,437 people aged 70 and over, collected from three long-running surveys covering the US, England and parts of Europe. The team used an algorithm that took into account participants' responses to a host of different metrics, from the difficulties they had with everyday activities to their scores on cognitive tests, to determine whether they were likely to have dementia. They then split the participants into eight different cohorts, representing different generations. Participants were also split into six age groups. As expected, the researchers found the prevalence of dementia increased by age among all birth cohorts, and in each of the three regions: UK, US and Europe. However, at a given age, people in more recent generations were less likely to have dementia compared with those in earlier generations.

"For example, in the US, among people aged 81 to 85, 25.1% of those born between 1890-1913 had dementia, compared to 15.5% of those born between 1939-1943," said Lenzen, adding similar trends were seen in Europe and England, although less pronounced in the latter. The team said the trend was more pronounced in women, especially in Europe and England, noting that one reason may be increased access to education for women in the mid-20th century. However, taking into account changes in GDP, a metric that reflects broader economic shifts, did not substantially alter the findings. A number of factors could be contributing to the decline. "This is likely due to interventions such as compulsory education, smoking bans, and improvements in medical treatments for conditions such as heart disease, diabetes, and hearing loss, which are associated with dementia risk," said Prof Tara Spires-Jones, the director of the Centre for Discovery Brain Sciences at the University of Edinburgh.

Automated web-scraping bots seeking training data for AI models are flooding scientific databases and academic journals with traffic volumes that render many sites unusable. The online image repository DiscoverLife, which contains nearly 3 million species photographs, started receiving millions of daily hits in February this year that slowed the site to the point that it no longer loaded, Nature reported Monday.

The surge has intensified since the release of DeepSeek, a Chinese large language model that demonstrated effective AI could be built with fewer computational resources than previously thought. This revelation triggered what industry observers describe as an "explosion of bots seeking to scrape the data needed to train this type of model." The Confederation of Open Access Repositories reported that more than 90% of 66 surveyed members experienced AI bot scraping, with roughly two-thirds suffering service disruptions. Medical journal publisher BMJ has seen bot traffic surpass legitimate user activity, overloading servers and interrupting customer services.

Adam Riess won a Nobel Prize in Physics for helping discover that the universe's acceleration is expanding, remembers The Atlantic. But then theorists "proposed the existence of dark energy: a faint, repulsive force that pervades all of empty space... the final piece to what has since come to be called the 'standard model of cosmology.'"

Riess thinks instead we should just replace the standard model: When I visited Riess, back in January, he mentioned he was looking forward to a data release from the Dark Energy Spectroscopic Instrument, a new observatory on Kitt Peak, in Arizona's portion of the Sonoran Desert. DESI has 5,000 robotically controlled optic fibers. Every 20 minutes, each of them locks onto a different galaxy in the deep sky. This process is scheduled to continue for a total of five years, until millions of galaxies have been observed, enough to map cosmic expansion across time... DESI's first release, last year, gave some preliminary hints that dark energy was stronger in the early universe, and that its power then began to fade ever so slightly. On March 19, the team followed up with the larger set of data that Riess was awaiting. It was based on three years of observations, and the signal that it gave was stronger: Dark energy appeared to lose its kick several billion years ago.

This finding is not settled science, not even close. But if it holds up, a "wholesale revision" of the standard model would be required [says Colin Hill, a cosmologist at Columbia University. "The textbooks that I use in my class would need to be rewritten." And not only the textbooks — the idea that our universe will end in heat death has escaped the dull, technical world of academic textbooks. It has become one of our dominant secular eschatologies, and perhaps the best-known end-times story for the cosmos. And yet it could be badly wrong. If dark energy weakens all the way to zero, the universe may, at some point, stop expanding. It could come to rest in some static configuration of galaxies. Life, especially intelligent life, could go on for a much longer time than previously expected.

If dark energy continues to fade, as the DESI results suggest is happening, it may indeed go all the way to zero, and then turn negative. Instead of repelling galaxies, a negative dark energy would bring them together into a hot, dense singularity, much like the one that existed during the Big Bang. This could perhaps be part of some larger eternal cycle of creation and re-creation. Or maybe not. The point is that the deep future of the universe is wide open...
"Many new observations will come, not just from DESI, but also from the new Vera Rubin Observatory in the Atacama Desert, and other new telescopes in space. On data-release days for years to come, the standard model's champions and detractors will be feverishly refreshing their inboxes..." And Riess tells The Atlantic he's disappointed when complacent theorists just tell him "Yeah, that's a really hard problem."

He adds, "Sometimes, I feel like I am providing clues and killing time while we wait for the next Einstein to come along."

An anonymous reader shared this report from Space.com: Three world travelers, two Space Camp alums and an aerospace executive whose last name aptly matched their shared adventure traveled into space and back Saturday, becoming the latest six people to fly with Blue Origin, the spaceflight company founded by billionaire Jeff Bezos.

Mark Rocket joined Jaime Alemán, Jesse Williams, Paul Jeris, Gretchen Green and Amy Medina Jorge on board the RSS First Step — Blue Origin's first of two human-rated New Shepard capsules — for a trip above the Kármán Line, the 62-mile-high (100-kilometer) internationally recognized boundary between Earth and space...

Mark Rocket became the first New Zealander to reach space on the mission. His connection to aerospace goes beyond his apt name and today's flight; he's currently the CEO of Kea Aerospace and previously helped lead Rocket Lab, a competing space launch company to Blue Origin that sends most of its rockets up from New Zealand. Alemán, Williams and Jeris each traveled the world extensively before briefly leaving the planet today. An attorney from Panama, Alemán is now the first person to have visited all 193 countries recognized by the United Nations, traveled to the North and South Poles, and now, have been into space. For Williams, an entrepreneur from Canada, Saturday's flight continued his record of achieving high altitudes; he has summitted Mt. Everest and five of the other six other highest mountains across the globe.
"For about three minutes, the six NS-32 crewmates experienced weightlessness," the article points out, "and had an astronaut's-eye view of the planet..."

On social media Blue Origin notes it's their 12th human spaceflight, "and the 32nd flight of the New Shepard program."

A 15-year-old asked the question — receiving an answer from an associate professor of psychology at Georgia Institute of Technology. They write (on The Conversation) that "As a brain scientist who studies perception, I fully expect mind uploading to one day be a reality.

"But as of today, we're nowhere close..." Replicating all that complexity will be extraordinarily difficult. One requirement: The uploaded brain needs the same inputs it always had. In other words, the external world must be available to it. Even cloistered inside a computer, you would still need a simulation of your senses, a reproduction of the ability to see, hear, smell, touch, feel — as well as move, blink, detect your heart rate, set your circadian rhythm and do thousands of other things... For now, researchers don't have the computing power, much less the scientific knowledge, to perform such simulations.

The first task for a successful mind upload: Scanning, then mapping the complete 3D structure of the human brain. This requires the equivalent of an extraordinarily sophisticated MRI machine that could detail the brain in an advanced way. At the moment, scientists are only at the very early stages of brain mapping — which includes the entire brain of a fly and tiny portions of a mouse brain. In a few decades, a complete map of the human brain may be possible. Yet even capturing the identities of all 86 billion neurons, all smaller than a pinhead, plus their trillions of connections, still isn't enough. Uploading this information by itself into a computer won't accomplish much. That's because each neuron constantly adjusts its functioning, and that has to be modeled, too. It's hard to know how many levels down researchers must go to make the simulated brain work. Is it enough to stop at the molecular level? Right now, no one knows.

Knowing how the brain computes things might provide a shortcut. That would let researchers simulate only the essential parts of the brain, and not all biological idiosyncrasies. Here's another way: Replace the 86 billion real neurons with artificial ones, one at a time. That approach would make mind uploading much easier. Right now, though, scientists can't replace even a single real neuron with an artificial one. But keep in mind the pace of technology is accelerating exponentially. It's reasonable to expect spectacular improvements in computing power and artificial intelligence in the coming decades.

One other thing is certain: Mind uploading will certainly have no problem finding funding. Many billionaires appear glad to part with lots of their money for a shot at living forever. Although the challenges are enormous and the path forward uncertain, I believe that one day, mind uploading will be a reality.
"The most optimistic forecasts pinpoint the year 2045, only 20 years from now. Others say the end of this century.

"But in my mind, both of these predictions are probably too optimistic. I would be shocked if mind uploading works in the next 100 years.

"But it might happen in 200..."

In December it looked like NASA's next administrator would be the billionaire businessman/space enthusiast who twice flew to orbit with SpaceX.

But Saturday the nomination was withdrawn "after a thorough review of prior associations," according to an announcement made on social media. The Guardian reports: His removal from consideration caught many in the space industry by surprise. Trump and the White House did not explain what led to the decision... In [Isaacman's] confirmation hearing in April, he sought to balance Nasa's existing moon-aligned space exploration strategy with pressure to shift the agency's focus on Mars, saying the US can plan for travel to both destinations. As a potential leader of Nasa's 18,000 employees, Isaacman faced a daunting task of implementing that decision to prioritize Mars, given that Nasa has spent years and billions of dollars trying to return its astronauts to the moon...

Some scientists saw the nominee change as further destabilizing to Nasa as it faces dramatic budget cuts without a confirmed leader in place to navigate political turbulence between Congress, the White House and the space agency's workforce.
"It was unclear whom the administration might tap to replace Isaacman," the article adds, though "One name being floated is the retired US air force Lt Gen Steven Kwast, an early advocate for the creation of the US Space Force..."

Ars Technica notes that Kwast, a former Lieutenant General in the U.S. Air Force, has a background that "seems to be far less oriented toward NASA's civil space mission and far more focused on seeing space as a battlefield — decidedly not an arena for cooperation and peaceful exploration."

"More than 200 climate and weather scientists from across the U.S. are taking part in a marathon livestream on YouTube," according to this report from Space.com. For 100 hours (that started Wednesday) they're sharing their scientific work and answering questions from viewers, "to prove the value of climate science," according to the article.

The event is being stated in protest of recent government funding cuts at NASA, the National Oceanic and Atmospheric Administration, the United States Geological Survey, and the National Science Foundation. (The event began with "scientists documenting their last few hours at NASA's Goddard Institute for Space Studies as the office was shuttered.") The marathon stream features mini-lectures, panels and question-and-answer sessions with hundreds of scientists, each speaking in their capacity as private citizens rather than on behalf of any institution. These include talks from former National Weather Service directors, Britney Schmidt, a groundbreaking glacier researcher, and legendary meteorologist John Morales.

In its first 30 hours, the stream got over 77,000 views.

Ultimately, the goal of the event is to give members of the public the chance to learn more about meteorology and climate science in an informal setting — and for free. "We really felt like the American public deserves to know what we do," Duffy said. However, many of the speakers and organizers also hope the transference of this knowledge will spur people to take action. The event's website features a link to 5 Calls, an organization that makes it easy for folks to contact their representatives in Congress about the importance of funding climate and weather research.

A five-year study by Wageningen University and the German Primate Research Center found that wild chimpanzees in Guinea-Bissau repeatedly strike stones against trees, presumably as a form of communication. Phys.Org reports: Over the course of a five-year field study, the research team collected video footage at five distinct locations within a nature reserve in Guinea-Bissau. This was made possible through the use of camera traps and with essential support from local field guides. In specific areas, a striking behavioral pattern was observed: adult male chimpanzees repeatedly struck stones against tree trunks, resulting in characteristic piles of stones at the base of these trees. [...]

The observations point to cultural transmission. Young chimpanzees adopt the behavior from older group members, indicating that it is learned socially rather than genetically inherited. Marc Naguib, Professor of Behavioral Ecology, underscores the broader significance of the discovery: "It illustrates that culture is not unique to humans and that such behaviors need to be considered also in nature conservation." The study is published in the journal Biology Letters.

For the first time, scientists have directly observed atmospheric sputtering in action on Mars -- an erosion process driven by solar wind ions that may have played a major role in the planet's atmospheric and water loss. ScienceAlert reports: The only spacecraft with the equipment and orbital configuration to make these observations is NASA's MAVEN. The researchers carefully pored over the data collected by the spacecraft since it arrived in Mars orbit in September 2014, looking to find simultaneous observations of the solar electric field and an upper atmosphere abundance of argon -- one of the sputtered particles, used as a tracer for the phenomenon. They found that, above an altitude of 350 kilometers (217 miles), argon densities vary depending on the orientation of the solar wind electric field, compared to argon densities at lower altitudes that remain consistent.

The results showed that lighter isotopes of argon vary, leaving behind an excess of heavy argon -- a discrepancy that is best explained by active sputtering. This is supported by observations of a solar storm, the outflows of which arrived at Mars in January 2016. During this time, the evidence of sputtering became significantly more pronounced. Not only does this support the team's finding that argon density variations at high Martian altitudes are the result of sputtering, it demonstrates what conditions may have been like billions of years ago, when the Sun was younger and rowdier, undergoing more frequent storm activity. The findings have been published in the journal Science Advances.

An anonymous reader quotes a report from The Guardian: Whether it is doing sums or working out what to text your new date, some tasks produce a furrowed brow. Now scientists say they have come up with a device to monitor such effort: an electronic tattoo, stuck to the forehead. The researchers say the device could prove valuable among pilots, healthcare workers and other professions where managing mental workload is crucial to preventing catastrophes. "For this kind of high-demand and high-stake scenario, eventually we hope to have this real-time mental workload decoder that can give people some warning and alert so that they can self-adjust, or they can ask AI or a co-worker to offload some of their work," said Dr Nanshu Lu, an author of the research from the University of Texas at Austin, adding the device may not only help workers avoid serious mistakes but also protect their health.

Writing in the journal Device, Lu and colleagues describe how using questionnaires to investigate mental workload is problematic, not least as people are poor at objectively judging cognitive effort and they are usually conducted after a task. Meanwhile, existing electroencephalography (EEG) and electrooculography (EOG) devices, that can be used to assess mental workload by measuring brain waves and eye movements respectively, are wired, bulky and prone to erroneous measurements arising from movements. By contrast, the "e-tattoo" is a lightweight, flexible, wireless device.

The black, wiggly path of the e-tattoo is composed of a graphite-based conductive material, and is attached to the forehead using conductive adhesive film. Four square EEG electrodes, positioned on the forehead, each detect a different region of brain activity -- with a reference electrode behind the ear -- while rectangular EOG electrodes, placed vertically and horizontally around the eyes, provide data about eye movements. Each of the stretchable electrodes is coated in an additional conductive material. The e-tattoo, which is bespoke and disposable, is connected to a reusable flexible printed circuit using conductive tape, while a lightweight battery can be clipped to the device. The device is expected to cost less than $200 and be accompanied with an app to alert the user if their mental workload is too high.

Astronomers have discovered a mysterious cosmic object, ASKAP J1832-0911, that emits both radio waves and X-rays in precise 44-minute cycles, making it unlike anything observed before. Space.com reports: This is the first time an object like this, a so-called "long-period transient" or "LPT," has been seen in high-energy X-ray light as well as low-energy radio wave light. The team behind this discovery hopes the finding could help reveal what these flashing objects actually are and how they launch their mystery signals. However, not only is there no explanation for how the signals from LPTs are generated yet, but astronomers also don't know why these signals "switch on" and "switch off" at long, regular and unusual intervals. "This object is unlike anything we have seen before," team leader and Curtin University researcher Zieng (Andy) Wang said in a statement. [...]

The team believes the true nature of ASKAP J1832-0911 is a dead star, they just don't quite know what form that star takes. A highly magnetic neutron star, or "magnetar," is one option, and a a white dwarf -- the kind of stellar remnant the sun will leave behind when it dies in over 5 billion years -- is another. "ASKAP J1831- 0911 could be a magnetar, the core of a dead star with powerful magnetic fields, or it could be a pair of stars in a binary system where one of the two is a highly magnetized white dwarf, a low-mass star at the end of its evolution," Wang said. "However, even those theories do not fully explain what we are observing. "This discovery could indicate a new type of physics or new models of stellar evolution." The research has been published in the journal Nature.

SpaceX's Starship Flight 9 successfully launched and reached space -- marking the first reuse of a Super Heavy booster -- but both rocket stages were ultimately lost mid-mission due to a "rapid unscheduled disassembly." SpaceX CEO Elon Musk said in a statement: "Starship made it to the scheduled ship engine cutoff, so big improvement over last flight! Leaks caused loss of main tank pressure during the coast and re-entry phase. Lot of good data to review." Musk said the next three Starship test launches could lift off every three to four weeks in the days ahead. Space.com reports: The mission lifted off from Starbase today at 7:37 p.m. EDT (2337 GMT; 6:37 p.m. local Texas time), sending the 40-story-tall rocket into the Texas sky atop a pillar of flame. It was a milestone launch, marking the first-ever reuse of a Super Heavy booster; this one earned its wings on Flight 7 in January. (SpaceX swapped out just four of its Raptors after that mission, meaning that 29 of the engines that flew today were flight-proven.) "Lessons learned from the first booster refurbishment and subsequent performance in flight will enable faster turnarounds of future reflights as progress is made towards vehicles requiring no hands-on maintenance between launches," the company wrote in a Flight 9 mission preview.

The Super Heavy had a somewhat different job to do today; it conducted a variety of experiments on its way back down to Earth. For example, the booster performed a controlled rather than randomized return flip and hit the atmosphere at a different angle. "By increasing the amount of atmospheric drag on the vehicle, a higher angle of attack can result in a lower descent speed, which in turn requires less propellant for the initial landing burn," SpaceX wrote in the mission preview. "Getting real-world data on how the booster is able to control its flight at this higher angle of attack will contribute to improved performance on future vehicles, including the next generation of Super Heavy." These experiments complicated Super Heavy's flight profile compared to previous missions, making another "chopsticks" catch at Starbase a tougher proposition. So, rather than risk damaging the launch tower and other infrastructure, SpaceX decided to bring the booster back for a "hard splashdown" in the Gulf of Mexico on Flight 9. That was the plan, anyway; Super Heavy didn't quite make it that far. The booster broke apart about 6 minutes and 20 seconds into today's flight, just after beginning its landing burn. "Confirmation that the booster did demise," [Dan Huot, of SpaceX's communications team] said during the Flight 9 webcast. Super Heavy's flight ended "before it was able to get through landing burn," he added.

Ship, by contrast, improved its performance a bit this time around. It reached space today on a suborbital trajectory that took it eastward over the Atlantic Ocean -- the same basic path the vehicle took on the truncated Flight 7 and Flight 8. But Flight 9 got choppy for Ship after that. The vehicle was supposed to deploy eight dummy versions of SpaceX's Starlink satellites about 18.5 minutes after liftoff, which would have been a landmark first for the Starship program. That didn't happen, however; the payload door couldn't open fully, so SpaceX abandoned the deployment try. Then, about 30 minutes after launch, Ship started to tumble, which was the result of a leak in Ship's fuel-tank systems, according to Huot. "A lot of those [tanks] are used for your attitude control," he said. "And so, at this point, we've essentially lost our attitude control with Starship." As a result, SpaceX nixed a plan to relight one of Ship's Raptor engines in space, a test that was supposed to happen about 38 minutes after launch. And the company gave up hope of a soft splashdown for the vehicle, instead becoming resigned to a breakup over the Indian Ocean during Ship's reentry.

The company therefore will not get all the data it wanted about Flight 9. And there was quite a bit to get; for example, SpaceX removed some of Ship's heat-shield tiles to stress-test vulnerable areas, and it also tried out several different tile materials, including one with an active cooling system. But the company plans to bounce back and try again soon, just as it did after Flight 7 and Flight 8. You can watch a recording of the launch on YouTube.

An anonymous reader shares a report: More than 2% of Americans are taking the blockbuster class of GLP-1 drugs for overweight or obesity, up nearly 600% over six years, according to a report from FAIR Health given to Axios first. The data from FAIR Health's repository of over 51 billion commercial healthcare claim records shows the explosion in use of the drugs specifically for weight loss -- roughly half of all users.

In all, roughly 4% of Americans were taking GLP-1 drugs in 2024 for either overweight, obesity or Type 2 diabetes (their original approved use). The data shows Novo Nordisk's Ozempic is still by far the most commonly taken GLP-1, followed by Eli Lilly's Mounjaro. The percentage of adults who were prescribed a GLP-1 drug but did not have bariatric surgery increased from 2.5% in 2019 to 11.2% in 2024 while the the percentage of adult patients who had bariatric surgery decreased 41.8%.

Researchers are developing techniques to genetically modify cancer-fighting immune cells directly inside patients rather than in expensive laboratory facilities, potentially making CAR-T therapy accessible to far more people.

Current CAR-T treatments require removing a patient's T cells, shipping them to specialized facilities for genetic engineering, then returning them weeks later at costs around $500,000 per dose. The new "in vivo" approaches use viral vectors or RNA-loaded nanoparticles to deliver genetic instructions directly to T cells circulating in the bloodstream, which could reduce costs by an order of magnitude. Companies including Capstan Therapeutics, co-founded by Nobel laureates, and AstraZeneca-backed EsoBiotec have launched early human trials. While only about 200 US centers currently offer traditional CAR-T therapy, the approach could make the powerful treatment available on demand like conventional drugs.

Abstract of a paper on NBER: We elicited over a million stated preference choices over 126 dimensions or "aspects" of well-being from a sample of 3,358 respondents on Amazon's Mechanical Turk (MTurk). Our surveys also collected self-reported well-being (SWB) questions about respondents' current levels of the aspects of well-being. From the stated preference data, we estimate relative log marginal utilities per point on our 0-100 response scale for each aspect. We validate these estimates by comparing them to alternative methods for estimating preferences. Our findings provide empirical evidence that both complements and challenges philosophical perspectives on human desires and values. Our results support Aristotelian notions of eudaimonia through family relationships and Maslow's emphasis on basic security needs, yet also suggest that contemporary theories of well-being may overemphasize abstract concepts such as happiness and life satisfaction, while undervaluing concrete aspects such as family well-being, financial security, and health, that respondents place the highest marginal utilities on. We document substantial heterogeneity in preferences across respondents within (but not between) demographic groups, with current SWB levels explaining a significant portion of the variation.