Acceptable levels of "forever chemicals" in drinking water should be reduced tenfold and a new national chemicals agency created to protect public health, the Royal Society of Chemistry (RSC) has told the UK government. From a report: The chartered body wants to see a reduction in the cap on levels of per- and polyfluoroalkyl substances (PFAS) in tap water. PFAS are a family of about 10,000 widely used chemicals that do not break down easily in the environment. Some have been linked to cancers, liver and thyroid disease, immune and fertility problems, and developmental defects in unborn children.

The current limit in UK drinking water, which is a guideline and not a statutory cap, is 100 nanograms a litre for individual PFAS. The RSC wants this reduced to 10ng/l and a new overall limit introduced of 100ng/l for a wider range of PFAS in drinking water. "In the Drinking Water Inspectorate's (DWI) own words, levels above 10ng/l pose a medium or high risk to public health," said Stephanie Metzger, a policy adviser at the RSC. "We're seeing more studies that link PFAS to a range of very serious medical conditions, and so we urgently need a new approach for the sake of public health."

Amazon has started delivering prescription medications by drone in a Texas city, broadening its still-experimental effort to deliver goods by air. From a report: The online retailer recently began listing drone delivery as an option for Amazon Pharmacy customers who are participating in a test program in College Station, one of two US cities where Amazon is delivering products using its unmanned, riding-lawnmower-sized vehicles. The company made the effort public on Wednesday ahead of a logistics press event held at a warehouse near Amazon's Seattle headquarters.

Quick delivery of medical supplies has emerged as one of the leading candidates for a viable delivery-by-drone business. Alphabet's Wing, United Parcel Service and drone startup Zipline have all set out to deliver medical goods, sometimes in trial programs centered around hospital campuses or planned communities. In most places, drone use remains limited to narrowly prescribed tests as regulators hash out regulations to limit risk to other aircraft and people on the ground.

An anonymous reader shares a report: On May 4, 2022, NASA's InSight lander detected the largest quake yet recorded on Mars, one with a 4.7 magnitude -- fairly modest by Earth standards but strong for our planetary neighbor. Given Mars lacks the geological process called plate tectonics that generates earthquakes on our planet, scientists suspected a meteorite impact had caused this marsquake. But a search for an impact crater came up empty, leading scientists to conclude that this quake was caused by tectonic activity -- rumbling in the planet's interior -- and giving them a deeper understanding about what makes Mars shake, rattle and roll.

"We concluded that the largest marsquake seen by InSight was tectonic, not an impact. This is important as it shows the faults on Mars can host hefty marsquakes," said planetary scientist Ben Fernando of the University of Oxford in England, lead author of the research published this week in the journal Geophysical Research Letters. "We really thought that this event might be an impact." "This represents a significant step forward in our understanding of Martian seismic activity and takes us one step closer to better unraveling the planet's tectonic processes," added Imperial College London planetary scientist and study co-author Constantinos Charalambous, co-chair of InSight's Geology Working Group.

NASA retired InSight in 2022 after four years of operations. In all, InSight's seismometer instrument detected 1,319 marsquakes. Earth's crust - its outermost layer - is divided into immense plates that continually shift, triggering quakes. The Martian crust is a single solid plate. But that does not mean all is quiet on the Martian front. "There are still faults that are active on Mars. The planet is still slowly shrinking and cooling, and there is still motion within the crust even though there are no active plate tectonic processes going on anymore. These faults can trigger quakes," Fernando said.

An anonymous reader quotes a report from Ars Technica: When British naturalist Charles Darwin sketched out his theory of evolution in the 1859 book "On the Origin of Species" -- proposing that biological species change over time through the acquisition of traits that favor survival and reproduction -- it provoked a revolution in scientific thought. Now 164 years later, nine scientists and philosophers on Monday proposed a new law of nature that includes the biological evolution described by Darwin as a vibrant example of a much broader phenomenon, one that appears at the level of atoms, minerals, planetary atmospheres, planets, stars and more. It holds that complex natural systems evolve to states of greater patterning, diversity and complexity.

Titled the "law of increasing functional information," it holds that evolving systems, biological and non-biological, always form from numerous interacting building blocks like atoms or cells, and that processes exist -- such as cellular mutation -- that generate many different configurations. Evolution occurs, it holds, when these various configurations are subject to selection for useful functions. [...] The authors proposed three universal concepts of selection: the basic ability to endure; the enduring nature of active processes that may enable evolution; and the emergence of novel characteristics as an adaptation to an environment. Some biological examples of this "novelty generation" include organisms developing the ability to swim, walk, fly and think. Our species emerged after the human evolutionary lineage diverged from the chimpanzee lineage and acquired an array of traits including upright walking and increased brain size. The research has been published in the journal Proceedings of the National Academy of Sciences.

Michael Kan reports via PCMag: Jeff Bezos' Blue Origin has announced a new spacecraft that promises to help humanity build and maintain projects in outer space. The company today debuted Blue Ring, a so-called "space platform" that can orbit Earth, but also travel around the Moon, with the goal of providing delivery and logistics support to other space projects. To do so, Blue Ring functions as a maneuverable platform that can host, transport, and refuel other spacecraft. In addition, it can relay data while also offering an "in-space" cloud computing capability, according to Blue Origin's announcement.

Other rockets, particularly those from rival SpaceX, can already send satellites up into predictable orbits around Earth. In contrast, Blue Ring is designed to serve customers for more "dynamic" space projects at varying orbits, Blue Origin Lars Hoffman VP tells Aviation Week. "It has a lot of capability and a lot of energy. It is a platform that has versatility across multiple missions and multiple customers on any given launch," Hoffman says.

The company adds that Blue Ring can travel with payloads of over 6,600 pounds. According to Aviation Week, Blue Origin is eyeing 2025 as a realistic launch date for the spacecraft, which has already received some interest from customers. Hoffman also says Blue Ring will be "launch-vehicle agnostic," allowing it to fly on a SpaceX Falcon 9 rocket or Blue Origin's own New Glenn, which is aiming to be used in its first mission next year.

In an analysis piece for The Guardian, Sean Ingle discusses some of the smart technology and artificial intelligence being used in sports to fight against brain injuries. From the report: There was a hidden spectator of the NFL match between the Baltimore Ravens and Tennessee Titans in London on Sunday: artificial intelligence. As crazy as it may sound, computers have now been taught to identify on-field head impacts in the NFL automatically, using multiple video angles and machine learning. So a process that would take 12 hours -- for each game -- is now done in minutes. The result? After every weekend, teams are sent a breakdown of which players got hit, and how often.

This tech wizardry, naturally, has a deeper purpose. Over breakfast the NFL's chief medical officer, Allen Sills, explained how it was helping to reduce head impacts, and drive equipment innovation. Players who experience high numbers can, for instance, be taught better techniques. Meanwhile, nine NFL quarterbacks and 17 offensive linemen are wearing position-specific helmets, which have significantly more padding in the areas where they experience more impacts. What may be next? Getting accurate sensors in helmets, so the force of each tackle can also be estimated, is one area of interest. As is using biomarkers, such as saliva and blood, to better understand when to bring injured players back to action.

If that's not impressive enough, this weekend rugby union became the first sport to adopt smart mouthguard technology, which flags big "hits" in real time. From January, whenever an elite player experiences an impact in a tackle or ruck that exceeds a certain threshold, they will automatically be taken off for a head injury assessment by a doctor. No wonder Dr Eanna Falvey, World Rugby's chief medical officer, calls it a "gamechanger" in potentially identifying many of the 18% of concussions that now come to light only after a match.

A study conducted by Duke University researchers suggests that glyphosate, the active ingredient in Roundup, may be a potential cause of the mysterious kidney disease CKDu that has affected rural communities in Sri Lanka and similar regions around the world. The findings have been published in Environmental Science and Technology Letters. Phys.Org reports: Roundup is a glyphosate-based herbicide used to control weeds and other pests. Because it is supposed to break down in the environment within a few days to weeks, its use is relatively under-regulated by most public health agencies. But when glyphosate encounters certain trace metal ions that make water hard -- like magnesium and calcium -- glyphosate-metal ion complexes can form. Those complexes can persist up to seven years in water and 22 years in soil. In certain agricultural areas of Sri Lanka, the high, dry climate combined with its geological formations creates the perfect conditions for hard water. It is also in these regions that CKDu has reached epidemic levels, with as many as 10% of children aged 5-11 years exhibiting signs of early onset kidney damage.

[Nishad Jayasundara, the Juli Plant Grainger Assistant Professor of Global Environmental Health at Duke] believed that glyphosate may play a role in CKDu incidence because of the region's hard water, even though Sri Lanka has banned use of the herbicide. To test his hypothesis, Jayasundara teamed up with environmental chemist Lee Ferguson, an associate professor of civil and environmental engineering at Duke and his Ph.D. student Jake Ulrich. In collaboration with Mangala De Silva, a professor at the University of Ruhuna, Sri Lanka, the Duke team sampled more than 200 wells across four regions in Sri Lanka. Ferguson's lab at Duke employs high-resolution and tandem mass spectrometry to identify contaminants -- even the barest trace of them -- by their molecular weights. It's a highly sensitive method of identification and quantitation that allows a broad view into the pollutants present in a water system. Through this technique, the researchers found significantly higher levels of the herbicide in 44% of wells within the affected areas versus just 8% of those outside it.

"We really focused on drinking water here, but it's possible there are other important routes of exposure -- direct contact from agricultural workers spraying the pesticide, or perhaps food or dust," said Ferguson. "I'd like to see increased study with more emphasis looking at the links among these exposure routes. It still seems like there might be things we're missing." To this point, Ulrich also found elevated levels of fluoride and vanadium -- both of which are linked to kidney damage -- in the drinking water of most all of the communities with high incidence of CKDu. The researchers agree that more attention must be paid to the potential contributions each of these contaminants is playing, either individually or in concert with others. But given the reasoning for their glyphosate-based hypothesis going into the study and the herbicide's high levels of use worldwide, they also believe these results should serve as a serious warning when considering risk of exposure to glyphosate.

Javier Milei, the current front runner for president of Argentina, pledged to eliminate government spending on research and shut down the country's main science agency, the National Scientific and Technical Research Council (CONICET), which provides funding for about 12,000 researchers at 300 institutions across the country. The libertarian candidate has said that shutting down CONICET, with its $400 million budget, could help to end Argentina's fiscal crisis. Martin De Ambrosio and Fermin Koop report via the scientific journal Nature: Milei is a relative newcomer to Argentine politics, having become a lawmaker in the lower chamber of the country's Congress only in 2021. Previously, he was an economic adviser to firms including Aeropuertos Argentina 2000, which manages airports in the country. He has also won notoriety as a guest on talk shows discussing economics and his services as a tantric sex coach. His rise was precipitated by eight years of economic turmoil in Argentina: the country owes billions to creditors such as the International Monetary Fund; annual inflation has reached more than 120%; and 40% of the population is living in poverty.

To tame the crisis, Milei has proposed not only privatizing science, but also closing the environment and health ministries, and abolishing the current public-health and education systems. The anti-establishment politician has even floated the idea of allowing people to sell their own organs for profit. On environmental issues, he is equally provocative, calling climate change "a socialist hoax," and saying that a company should be able to pollute a river as it sees fit. "From his perspective, any regulatory intervention by the state represents an attack against market freedom and, therefore, against individual freedom," says Maristella Svampa, a sociologist at the CONICET-funded Center for Documentation and Research of Left-Wing Culture in Buenos Aires.

Milei has tapped into the public's angst. He is currently leading the polls, although electoral experts don't necessarily trust the figures, and his competitors still hope to win the upper hand. [...] If Milei becomes president, say sources who spoke to Nature, researchers will leave the country to seek jobs. They will be able to make a living elsewhere because they are talented, [says Jorge Aliaga, a physicist at Hurlingham National University in Buenos Aires]. But "losing scientists is a problem for the country." Because of economic crises that have long dogged Argentina, brain drain is a regular threat. Hyperinflation in the late 1980s and a banking crisis in 2001 drove thousands of scientists to seek work in Europe and the United States. Even so, Argentina still has one of the best ratios of researchers to inhabitants in Latin America, Aliaga says. In 2014, for instance, it had about 1,200 researchers for every one million inhabitants. By contrast, Brazil had about 890 for every one million people. "In that sense, Argentina has better numbers than Brazil and Mexico," Aliaga adds.

This week Bloomberg explored so-called "zombie viruses" — that is, long-dormant microbes which they call "yet another risk that climate change poses to public health" as ground that's been frozen for "milleniums" suddenly starts thawing — for example, in the Arctic, which they write is warming "faster than any other area on earth." With the planet already 1.2C warmer than pre-industrial times, scientists are predicting the Arctic could be ice-free in summers by 2030s. Concerns that the hotter climate will release trapped greenhouse gases like methane into the atmosphere as the region's permafrost melts have been well-documented, but dormant pathogens are a lesser explored danger. Last year, virologist Jean-Michel Claverie's team published research showing they'd extracted multiple ancient viruses from the Siberian permafrost, all of which remained infectious...

Ways in which this could present a threat are still emerging. A heat wave in Siberia in the summer of 2016 activated anthrax spores, leading to dozens of infections, killing a child and thousands of reindeer. In July this year, a separate team of scientists published findings showing that even multicellular organisms could survive permafrost conditions in an inactive metabolic state, called cryptobiosis. They successfully reanimated a 46,000-year-old roundworm from the Siberian permafrost, just by re-hydrating it...

Claverie first showed "live" viruses could be extracted from the Siberian permafrost and successfully revived in 2014. For safety reasons his research focused only on viruses capable of infecting amoebas, which are far enough removed from the human species to avoid any risk of inadvertent contamination. But he felt the scale of the public health threat the findings indicated had been under-appreciated or mistakenly considered a rarity. So, in 2019, his team proceeded to isolate 13 new viruses, including one frozen under a lake more than 48,500 years ago, from seven different ancient Siberian permafrost samples — evidence to their ubiquity. Publishing the findings in a 2022 study, he emphasized that a viral infection from an unknown, ancient pathogen in humans, animals or plants could have potentially "disastrous" effects.

"50,000 years back in time takes us to when Neanderthal disappeared from the region," he says. "If Neanderthals died of an unknown viral disease and this virus resurfaces, it could be a danger to us."

Long-time Slashdot reader SonicSpike shared the Washington Post's speculation about the possibility of a gigantic solar storm leaving millions without phone or internet access, and requiring months or years of rebuilding: The odds are low that in any given year a storm big enough to cause effects this widespread will happen. And the severity of those impacts will depend on many factors, including the state of our planet's magnetic field on that day. But it's a near certainty that some form of this catastrophe will happen someday, says Ian Cohen, a chief scientist who studies heliophysics at the Johns Hopkins Applied Physics Laboratory.
Long-time Slashdot reader davidwr remains skeptical. "I've only heard of two major events in the last 1300 years, one estimated to be between A. D. 744 and A. D. 993, and the other being the Carrington Event in 1859.

But efforts are being made to improve our readiness, reports the Washington Post: To get ahead of this threat, a loose federation of U.S. and international government agencies, and hundreds of scientists affiliated with those bodies, have begun working on how to make predictions about what our Sun might do. And a small but growing cadre of scientists argue that artificial intelligence will be an essential component of efforts to give us advance notice of such a storm...

At present, no warning system is capable of giving us more than a few hours' notice of a devastating solar storm. If it's moving fast enough, it could be as little as 15 minutes. The most useful sentinel — a sun-orbiting satellite launched by the U.S. in 2015 — is much closer to Earth than the sun, so that by the time a fast-moving storm crosses its path, an hour or less is all the warning we get. The European Space Agency has proposed a system to help give earlier warning by putting a satellite dubbed Vigil into orbit around the Sun, positioned roughly the same distance from the Earth as the Earth is from the Sun. It could potentially give us up to five hours of warning about an incoming solar storm-enough time to do the main thing that can help preserve electronics: Switch them all off.

But what if there were a way to predict this better, by analyzing the data we've got? That's the idea behind a new, AI-powered model recently unveiled by scientists at the Frontier Development Lab — a public-private partnership that includes NASA, the U.S. Geological Survey, and the U.S. Department of Energy. The model uses deep learning, a type of AI, to examine the flow of the solar wind, the usually calm stream of particles that flow outward from our sun and through the solar system to well beyond the orbit of Pluto. Using observations of that solar wind, the model can predict the "geomagnetic disturbance" an incoming solar storm observed by sun-orbiting satellites would cause at any given point on Earth, the researchers involved say. This model can predict just how big the flux of the Earth's magnetic field will be when the solar storm arrives, and thus how big the induced currents in power lines and undersea internet cables will be...

Already, the first primitive ancestor of future AI-based solar-weather alert systems is live. The DstLive system, which debuted on the web in December 2022, uses machine learning to take data about the state of Earth's magnetic field and the solar wind and translate both into a single measure for the entire planet, known as DST. Think of it as the Richter scale, but for solar storms. This number is intended to give us an idea of how intense a storm's impact will be on earth, an hour to six hours in advance.

Unfortunately, we may not know how useful such systems are until we live through a major solar storm.

Richard Tribou reports via Phys.Org: NASA's goal to reduce the costs of the powerful Space Launch System rocket for its Artemis program by 50% was called "highly unrealistic" and a threat to its deep space exploration plans, according to a report by NASA's Office of the Inspector General released (PDF) on Thursday. The audit says the costs to produce one SLS rocket through its proposed fixed-cost contract will still top $2.5 billion, even though NASA thinks it can shrink that through "workforce reductions, manufacturing and contracting efficiencies, and expanding the SLS's user base."

"Given the enormous costs of the Artemis campaign, failure to achieve substantial savings will significantly hinder the sustainability of NASA's deep space human exploration efforts," the report warns. The audit looked at NASA's plans to shift from its current setup among multiple suppliers for the hardware to a sole-sourced services contract that would include the production, systems integration and launch of at least five SLS flights beginning with Artemis V currently slated for as early as 2029. NASA's claim it could get those costs to $1.25 billion per rocket was taken to task by the audit.

"NASA's aspirational goal to achieve a cost savings of 50% is highly unrealistic. Specifically, our review determined that cost saving initiatives in several SLS production contracts were not significant," the audit reads. It does find that rocket costs could approach $2 billion through the first 10 SLS rockets under the new contract, a reduction of 20%. [...] Through 2025, the audit stated its Artemis missions will have topped $93 billion, which includes billions more than originally announced in 2012 as years of delays and cost increases plagued the leadup to Artemis I. The SLS rocket represents 26% of that cost to the tune of $23.8 billion. The inspector general makes several recommendations to NASA. The most striking of which is that NASA consider using commercial heavy-lift rockets, such as SpaceX's Starship and Super Heavy or Blue Origin's New Glenn, as an alternative to the SLS rocket for future Artemis missions.

"Although the SLS is the only launch vehicle currently available that meets Artemis mission needs, in the next 3 to 5 years other human-rated commercial alternatives that are lighter, cheaper, and reusable may become available," the audit reads. "Therefore, NASA may want to consider whether other commercial options should be a part of its mid- to long-term plans to support its ambitious space exploration goals."

Matthew Sparkes reports via NewScientist: A prominent cryptography expert has told New Scientist that a US spy agency could be weakening a new generation of algorithms designed to protect against hackers equipped with quantum computers. Daniel Bernstein at the University of Illinois Chicago says that the US National Institute of Standards and Technology (NIST) is deliberately obscuring the level of involvement the US National Security Agency (NSA) has in developing new encryption standards for "post-quantum cryptography" (PQC). He also believes that NIST has made errors -- either accidental or deliberate -- in calculations describing the security of the new standards. NIST denies the claims.

Bernstein alleges that NIST's calculations for one of the upcoming PQC standards, Kyber512, are "glaringly wrong," making it appear more secure than it really is. He says that NIST multiplied two numbers together when it would have been more correct to add them, resulting in an artificially high assessment of Kyber512's robustness to attack. "We disagree with his analysis," says Dustin Moody at NIST. "It's a question for which there isn't scientific certainty and intelligent people can have different views. We respect Dan's opinion, but don't agree with what he says." Moody says that Kyber512 meets NIST's "level one" security criteria, which makes it at least as hard to break as a commonly used existing algorithm, AES-128. That said, NIST recommends that, in practice, people should use a stronger version, Kyber768, which Moody says was a suggestion from the algorithm's developers.

NIST is currently in a period of public consultation and hopes to reveal the final standards for PQC algorithms next year so that organizations can begin to adopt them. The Kyber algorithm seems likely to make the cut as it has already progressed through several layers of selection. Given its secretive nature, it is difficult to say for sure whether or not the NSA has influenced the PQC standards, but there have long been suggestions and rumors that the agency deliberately weakens encryption algorithms. In 2013, The New York Times reported that the agency had a budget of $250 million for the task, and intelligence agency documents leaked by Edward Snowden in the same year contained references to the NSA deliberately placing a backdoor in a cryptography algorithm, although that algorithm was later dropped from official standards.

Is the asteroid Psyche really a hunk of mostly metal? Is the object, which is nearly as wide as Massachusetts, the core of a baby planet whose rocky outer layers were knocked off during a cataclysmic collision in the early days of the solar system? Right now, all that astronomers can say is maybe, maybe not. NASA launched a spacecraft on Friday morning, also named Psyche, on a journey to the asteroid belt between Mars and Jupiter to find out. From a report: "We're really going to see a kind of new object, which means that a lot of our ideas are going to be proven wrong," said Lindy Elkins-Tanton, a professor of earth and space exploration at Arizona State University who serves as the mission's principal investigator.

Being proven wrong, she added, "is, I think, the most exciting thing in science." That voyage in search of answers kicked off Friday at 10:19 a.m. Eastern time. Falcon Heavy, the largest of SpaceX's operational rockets, lifted off from Kennedy Space Center in Florida, sending the massive spacecraft on a journey that will last about six years and travel billions of miles. Friday's flight overcame early, unfavorable weather forecasts for a seemingly flawless flight. About eight minutes into the flight, the rocket's upper stage entered a 45-minute coasting period during which it will prepare to deploy the spacecraft on its flight away from Earth. The asteroid named Psyche has long been a curious enigma. Spotted in 1852 by Annibale de Gasparis, an Italian astronomer, it is named for the Greek goddess of the soul, and it was just the 16th asteroid to be discovered. In the early observations, it was, like the other asteroids, a starlike point of light that moved in an orbit around the sun, and not much more.

Ed Cara reports via Gizmodo: Scientists appear to have developed a hand prosthetic that provides much more control and comfort than those available today. In new research this week, they've detailed the case of a Swedish woman who has successfully worn the advanced bionic limb for years with no major issues, while experiencing significantly less pain than before. The woman, identified as Karin, suffered a farming injury that took much of her right arm below the elbow over 20 years ago. Like many amputees, Karin went on to develop phantom limb pain, which required her to take high doses of medication to manage. She also benefited little from conventional prosthetics, finding them too unwieldy to use for daily life. But several years ago, Karin became one of the first patients enrolled in the DeTOP project, an expansive research study funded by the European Union and involving dozens of scientists across Europe that's looking to develop the next generation of bionic limbs.

Karin's prosthesis was created by the Italian company Presilia and is nicknamed Mia Hand. It's outfitted with state-of-art technology, including AI. And to further improve its functionality, her surgeons performed osseointegration during the attachment procedure, a process that directly fuses bone to the implant, ideally creating a stronger mechanical connection. They also implanted electrodes in her arm muscles and nerves, as well as rewired some of her nerves in the remaining part of the arm. The result is a robotic limb that's directly connected to Karin's neuromusculoskeletal system.

Much like a real flesh-and-blood hand, it's controlled by Karin's nervous system and provides sensory feedback. Her new hand can purportedly perform around 80% of the typical daily tasks that a regular limb would be able to do. And it's substantially reduced her phantom limb pain and the need for medication. The team's findings on Mia Hand's initial success are published in the journal Science Robotics. Karin is one of three patients enrolled in the DeTOP project. And while it may take time for the research on these patients to reach completion, the hope is that these prosthetics can eventually become the new standard for upper limb amputees. For Karin, it's already been a tremendous gift.

An anonymous reader quotes a report from the Financial Times: A world-first trial of a gene therapy to cure a form of deafness has begun, potentially heralding a revolution in the treatment of hearing loss. Up to 18 children from the UK, Spain and the US are being recruited to the study, which aims to transform treatment of auditory neuropathy, a condition caused by the disruption of nerve impulses traveling from the inner ear to the brain. Participants will be monitored for five years to gauge whether their hearing improves, with initial results expected to be published next February.

Auditory neuropathy can be due to a variation in a single gene -- known as the OTOF gene -- which produces a protein called otoferlin. This protein typically allows the inner hair cells in the ear to communicate with the hearing nerve. Mutations in the OTOF gene can be identified by genetic testing. However, [Professor Manohar Bance, an ear surgeon at Cambridge University Hospitals NHS Foundation Trust who is leading the trial in the UK] said it was a condition often missed when newborn babies were screened for potential hearing problems. "This is one of the few conditions where everything works except the transmission between the hair cells and the nerve. So everything else looks fine when you test it, but they can't hear anything. So these poor kids' [difficulties] end up being missed," Bance added.

The new gene therapy aims to deliver a working copy of the faulty OTOF gene using a modified, non-pathogenic virus. It will be delivered via an injection into the cochlea under general anaesthetic. Bance estimates that about 20,000 people across the US and five European countries -- the UK, Germany, France, Spain and Italy -- have auditory neuropathy due to OTOF mutations, underlining the potential significance of a successful treatment.[...] "If it works, it's 'one and done'" but the cost to health systems "is something that worries me," he added, noting that gene therapies could be priced in "the million dollar range" per patient. However, he hoped that "economies of scale" as the technology developed further would ultimately allow them to be provided more cheaply.

Scientists have used the gene-editing technology known as CRISPR to create chickens that have some resistance to avian influenza, according to a new study that was published in the journal Nature Communications on Tuesday. From a report: The study suggests that genetic engineering could potentially be one tool for reducing the toll of bird flu, a group of viruses that pose grave dangers to both animals and humans. But the study also highlights the limitations and potential risks of the approach, scientists said. Some breakthrough infections still occurred, especially when gene-edited chickens were exposed to very high doses of the virus, the researchers found. And when the scientists edited just one chicken gene, the virus quickly adapted. The findings suggest that creating flu-resistant chickens will require editing multiple genes and that scientists will need to proceed carefully to avoid driving further evolution of the virus, the study's authors said.

The research is "proof of concept that we can move toward making chickens resistant to the virus," Wendy Barclay, a virologist at Imperial College London and an author of the study, said at a news briefing. "But we're not there yet." Some scientists who were not involved in the research had a different takeaway. "It's an excellent study," said Dr. Carol Cardona, an expert on bird flu and avian health at the University of Minnesota. But to Dr. Cardona, the results illustrate how difficult it will be to engineer a chicken that can stay a step ahead of the flu, a virus known for its ability to evolve swiftly. "There's no such thing as an easy button for influenza," Dr. Cardona said. "It replicates quickly, and it adapts quickly."

The jackpot from a seven-year mission to bring back bits of an asteroid was unveiled on Wednesday. From a report: NASA officials in Houston displayed images of salt-and-pepper chunks of rock and particles of dark space dust that were brought back to Earth from the asteroid, Bennu, and described initial scientific observations about the material. The mission, Osiris-Rex, concluded in September when a capsule full of asteroid was jettisoned through Earth's atmosphere and recovered in the Utah desert. The first pieces of materials that leaked outside the container were analyzed using a variety of laboratory techniques, revealing just the earliest findings.

Scientists found water molecules trapped in clay minerals -- water from asteroids similar to Bennu could have filled Earth's oceans. "The reason that Earth is a habitable world, that we have oceans and lakes and rivers and rain, is because these clay minerals, like minerals, like the ones we're seeing from Bennu, landed on Earth four billion years ago," Dante Lauretta, the mission's principal investigator, said during a NASA event on Wednesday. The materials also contained sulfur, key for many geological transformations in rocks.

"It determines how quickly things melt and it is also critical for biology," said Dr. Lauretta, who displayed microscopic images and 3-D visualizations of the material. The scientists also found magnetite, an iron oxide mineral that can play an important role as a catalyst in organic chemical reactions. "We're looking at the kinds of minerals that may have played a central role in the origin of life on Earth," Dr. Lauretta said. The samples are also chock-full of carbon, the element that is the building block for life.

US Space Force has temporarily banned the use of web-based generative AI tools and so-called large language models that power them, citing data security and other concerns, Bloomberg News reported Wednesday, citing a memo. From the report: The Sept. 29 memorandum, addressed to the Guardian Workforce, the term for Space Force members, pauses the use of any government data on web-based generative AI tools, which can create text, images or other media from simple prompts. The memo says they "are not authorized" for use on government systems unless specifically approved.

Chatbots and tools like OpenAI's ChatGPT have exploded in popularity. They make use of language models that are trained on vast amounts of data to predict and generate new text. Such LLMs have given birth to an entire generation of AI tools that can, for example, search through troves of documents, pull out key details and present them as coherent reports in a variety of linguistic styles. Generative AI "will undoubtedly revolutionize our workforce and enhance Guardian's ability to operate at speed," Lisa Costa, Space Force's chief technology and innovation officer, said in the memo. But Costa also cited concerns over cybersecurity, data handling and procurement requirements, saying that the adoption of AI and LLMs needs to be "responsible."

A physicist from the University of Portsmouth has explored whether a new law of physics could support the theory that we're living in a computer simulation. Phys.Org reports: Dr. Melvin Vopson has previously published research suggesting that information has mass and that all elementary particles -- the smallest known building blocks of the universe -- store information about themselves, similar to the way humans have DNA. In 2022, he discovered a new law of physics that could predict genetic mutations in organisms, including viruses, and help judge their potential consequences. It is based on the second law of thermodynamics, which establishes that entropy -- a measure of disorder in an isolated system -- can only increase or stay the same. Dr. Vopson had expected that the entropy in information systems would also increase over time, but on examining the evolution of these systems he realized it remains constant or decreases. That's when he established the second law of information dynamics, or infodynamics, which could significantly impact genetics research and evolution theory.

A new paper, published in AIP Advances, examines the scientific implications of the new law on a number of other physical systems and environments, including biological, atomic physics, and cosmology. Key findings include:

- Biological systems: The second law of infodynamics challenges the conventional understanding of genetic mutations, suggesting that they follow a pattern governed by information entropy. This discovery has profound implications for fields such as genetic research, evolutionary biology, genetic therapies, pharmacology, virology, and pandemic monitoring.
- Atomic physics: The paper explains the behavior of electrons in multi-electron atoms, providing insights into phenomena like Hund's rule; which states that the term with maximum multiplicity lies lowest in energy. Electrons arrange themselves in a way that minimizes their information entropy, shedding light on atomic physics and stability of chemicals.
- Cosmology: The second law of infodynamics is shown to be a cosmological necessity, with thermodynamic considerations applied to an adiabatically expanding universe supporting its validity. "The paper also provides an explanation for the prevalence of symmetry in the universe," added Dr. Vopson. "Symmetry principles play an important role with respect to the laws of nature, but until now there has been little explanation as to why that could be. My findings demonstrate that high symmetry corresponds to the lowest information entropy state, potentially explaining nature's inclination towards it."

"This approach, where excess information is removed, resembles the process of a computer deleting or compressing waste code to save storage space and optimize power consumption. And as a result supports the idea that we're living in a simulation."

Nature's global survey finds that postdoctoral researchers still feel as though they are academia's drudge labourers, but have more confidence about job prospects in a post-pandemic world. Nature: In 2020, respondents to Nature's first global survey of postdoctoral researchers feared that COVID-19 would jeopardize their work. Eighty per cent said the pandemic had hindered their ability to carry out experiments or collect data, more than half (59%) found it harder to discuss their research with colleagues than before the crisis, and nearly two-thirds (61%) thought that the pandemic was hampering their career prospects.

That outlook has changed, according to Nature's second global postdoc survey, carried out in June and July this year. Now only 8% of the respondents say the economic impacts of COVID-19 are their biggest concern (down from 40% in 2020). Instead, they are back to worrying about the usual things: competition for funding, not finding jobs in their fields of interest or feeling pressure to sacrifice personal time for work. Overall, 55% say they are satisfied in their current postdoc, a slide from 60% in 2020. This varies by geography, age and subject area. Postdocs aged 30 and younger are more likely to be satisfied (64%) than are those aged 31-40 (53%). Biomedical postdocs -- who make up slightly more than half of the respondents -- pull the average down, because only 51% say they are satisfied with their jobs.