The Guardian reports: Scientists have pinpointed pieces of DNA which, they say, act like Bond villains in the way they help cancers spread. These microscopic agents have also been shown to be responsible for helping tumours gain resistance to anti-cancer drugs. The discovery of these bits of genetic material — known as extrachromosomal DNA or ecDNA — could revolutionise the treatments of some of the most aggressive tumours that affect people today, add the researchers....

Made up of tiny loops of DNA, these genetic villains survive outside the chromosomes which are our cells' main repositories of genetic material.... "We have found that ecDNA act as cancer-causing genes that have somehow separated themselves from a person's chromosomes and have started to behave in ways that circumvent the normal rules of genetics," said Stanford university geneticist Howard Chang. "They behave like villains in a Bond film. At first, in a film, you see different explosions, killings and disasters occurring and you don't know why they are happening or who is responsible. Then, at some point, you finally meet the villain who is revealed to be the agent of all this mayhem."
They also seem to resemble the Bond henchman who re-appears at the end of the movie. Professor Paul Mischel of California's Stanford University says that when treating the most aggressive cancers, "The vulnerable gene had quickly disappeared when threatened by cancer drugs and was hidden in ecDNA. Then it reappeared once it was safe for it to start causing damage again."

Mischel calls the discovery "a gamechanger," identifying the culprit "responsible for a large number of the more advanced, most serious cancers affecting people today. If we can block their activities, we can block the spread of these cancers."

And that hope was echoed by Dr Mariam Jamal-Hanjani of University College London Cancer Institute "The crucial point is that once we have found the cause of the problem then it becomes possible to develop and try out all sorts of drugs and therapies to tackle that." * "The discovery of how these bits of DNA behave inside our bodies is a gamechanger," said Professor Paul Mischel of California's Stanford university, one of the leaders of the programme. "We believe they are responsible for a large number of the more advanced, most serious cancers affecting people today. If we can block their activities, we can block the spread of these cancers."

HealthDay reports: If you spend hours a day scrolling on your smartphone or tablet, you might get "tech neck."

"Humans are upright creatures, and our bodies aren't designed to look down for long periods of time, which puts extra pressure on the cervical spine," said Dr. Kavita Trivedi, associate medical director of the Spine Center at UT Southwestern Medical Center in Dallas. Americans spend about five hours a day on their cellphones and more on laptops and computers, Trivedi noted in a university news release. As a result, people can experience muscle stiffness, joint inflammation, pinched nerves, arthritis, and even bone spurs or herniated discs. ...

"The good news is that most patients with tech neck don't require surgery, and we have a wide range of therapies that can be very effective," Trivedi said. "There's no need to live with pain if it can be treated."

Protect yourself from future neck pain by holding your phone at eye level as much as possible, she advised.
Thanks to long-time Slashdot reader schwit1 for submitting the article.

"Astronomers spotted an unexpected trail in the gas surrounding a dwarf galaxy while using the Hubble Space Telescope...." writes Hot Hardware. "The light emitting from the trail traveled more than 7.5 billion years to reach Earth and is thought to be traveling at a breakneck speed of 1,600km/s (3.5 million mph).

Science Alert says it could be "the smoking gun pointing to a runaway supermassive black hole."

More from Universe Today: Supermassive black holes (SMBHs) lurk in the center of large galaxies like ours. From their commanding position in the galaxy's heart, they feed on gas, dust, stars, and anything else that strays too close, growing more massive as time passes. But in rare circumstances, an SMBH can be forced out of its position and hurtle through space as a rogue SMBH.

In a new paper, researchers from Canada, Australia, and the USA present evidence of a rogue SMBH that's tearing through space and interacting with the circumgalactic medium (CGM.) Along the way, the giant is creating shock waves and triggering star formation.... The paper hasn't been peer-reviewed yet....

In their paper, the authors explain how an SMBH can be cast out of its host galaxy. It always starts when galaxies merge. That leads to the formation of a binary SMBH at the center of the merger remnant. The binary SMBH can be very long-lived, surviving for as long as one billion years before merging. If during that time, a third SMBH reaches the galactic center, then a three-body interaction can give one of the SMBHs a velocity boost, and it can be driven from the galaxy.
Hot Hardware adds that "This is not the first time a supermassive black hole has been found ejected from the center of its host galaxy. However, this is the first time one has been detected speeding across intergalactic space and believed to be inactive."

And RockDoctor (Slashdot reader #15,477) explains that "After the collision and ejection from the galaxy core, the passage of the black hole through the galaxy and it's surrounding material produced a burst of star formation along that line, which we now see as a faint linear streak of light....

"Those who like doom-laden prophecies will be upset to hear that, because we can see this moving across the plane of the sky, it is never going to come any where near us."

Stanford University president Marc Tessier-Lavigne was formerly executive vice president for research and chief scientific officer at biotech giant Genentech, according to his page on Wikipedia. "In 2022, Stanford University opened an investigation into allegations of Tessier-Lavigne's involvement in fabricating results in articles published between 2001 and 2008."

But Friday Stanford's student newspaper published even more allegations: In 2009, Marc Tessier-Lavigne, then a top executive at the biotechnology company Genentech, was the primary author of a scientific paper published in the prestigious journal Nature that claimed to have found the potential cause for brain degeneration in Alzheimer's patients. "Because of this research," read Genentech's annual letter to shareholders, "we are working to develop both antibodies and small molecules that may attack Alzheimer's from a novel entry point and help the millions of people who currently suffer from this devastating disease."

But after several unsuccessful attempts to reproduce the research, the paper became the subject of an internal review by Genentech's Research Review Committee (RRC), according to four high-level Genentech employees at the time... The scientists, one of whom was an executive who sat on the review committee and all of whom were informed of the review's findings at the time due to their stature at the company, said that the inquiry discovered falsification of data in the research, and that Tessier-Lavigne kept the finding from becoming public.

Tessier-Lavigne denies both allegations. Genentech said in a statement that "as part of our diligence related to these allegations, we reviewed the records from that November 2011 RRC meeting and saw no allegations of fraud or wrongdoing." The company acknowledged that "given that these events happened many years ago ... our current records may not be complete."

After the review, which began in 2011, Genentech canceled research based on the paper's findings. Till Maurer, a senior scientist at the company from 2009-2018 who said he was assigned to develop drugs based on the 2009 paper, told The Daily that his superior informed him that, in Maurer's words, "the project is being canceled and it's because they found falsified data...."

According to the executive who was part of the committee that reviewed the paper, the inquiry was thorough and left little room for doubt. Laboratory technicians and assistants were interviewed while scientists independent of the lab attempted to verify the findings of the study. "None of [the research review committee members] believed that these data were true by the time people had attempted to reproduce it," the executive said. He said that the understanding of the research committee was that the paper's supposed finding of N-APP's role in Alzheimer's had been "faked," and used "made up" figures as evidence.

The CBC reports: You may have seen stories over the past week or so with headlines like, "Part of the sun breaks free and forms a strange vortex, baffling scientists," or "Unbelievable moment a piece of the sun BREAKS OFF baffles scientists" or even "NASA captures piece of sun breaking off, baffles scientists." It all started with a harmless, informative tweet. Tamitha Skov, a space weather forecaster and science communicator, just broke away from the main filament... Implications for understanding the sun's atmospheric dynamics above 55 degrees here cannot be overstated!"

But are scientists actually baffled? Tamitha Skov laughs. "No," she said....

The eight-hour event started off with a solar prominence (also known as a solar filament), that began to rise up near the north pole of the sun, which is seen at the top in satellite images. Prominences are made up of plasma, a hot gas of electrically charged hydrogen and helium. They are common on the sun, but it was the location of this one — at the sun's north pole — that was of particular interest to heliophysicists. "What ended up happening was something that started off as a very normal, average, what we call a polar crown filament. It became this kind of tweeted her excitement that "material from a northern prominence big tower, like a big volcano that was beginning to rise up near the very northern pole," Skov explained. The prominence was near the top of the north pole, above 60 degrees latitude where it got caught in an electromagnetic wind. "And it began to yank and pull at some of the material in that prominence," Skov said.

"So it was rising like a hot air balloon, so to speak, up in the air. And as it cooled, instead of just cooling back down and falling, or perhaps erupting, like a normal polar crown filament, part of it got ripped off in this wind. And as it shredded off into this wind, we got to watch it cool down, swirl in a vortex. And that is a very rare, if not, fundamentally new observation."
It looks like the material ultimately just returns to the surface of the sun -- albeit providing clues about the sun's polar winds and the specifics of its magnetic activity cycle.

Skov also says that the sun's magnetic polar fields "flip" during its 22-year solar cycle, which increases the odds of non-charged particles traveling to the poles, according to the article. "So scientists weren't baffled, since they already had some knowledge about this type of activity. But they were thrilled to be able to witness it."

Thanks to long-time Slashdot reader aduxorth for sharing the news.

A new study on added sugars (also known as "free sugars") concluded they're bad for your health, reports NBC News.

"The research, published in the journal BMC Medicine, found that diets higher in free sugars — a category that includes sugar added to processed foods and sodas, as well as that found in fruit juice and syrups — raise one's risk of heart disease and stroke." The study relied on data about the eating habits of more than 110,000 people ages 37 to 73 in the United Kingdom, whose health outcomes were then tracked over about nine years. The results suggested that each 5% increase in the share of a person's total energy intake that comes from free sugars was associated with a 6% higher risk of heart disease and a 10% higher risk of stroke.

An author of the study, Cody Watling, a doctoral student at the University of Oxford, said the most common forms of sugar the study participants ate were "preserves and confectionary," with the latter category including cookies, sugary pastries and scones. Fruit juice, sugar-sweetened beverages and desserts were also common, he added.... The people found to have the highest risk of heart disease or stroke consumed about 95 grams of free sugar per day, or 18% of their daily energy intake, Watling said. By comparison, U.S. guidelines suggest that added sugars should make up no more than 10% of one's daily calories.

"Avoiding sugar-sweetened beverages is probably the single most important thing we can be doing," said Walter Willett, a professor of epidemiology and nutrition at Harvard University who was not involved in the study. Willett added that although there are some health benefits to drinking a small glass of orange juice occasionally, its sugar content means "a glass of fruit juice is the same thing as Coke...."

The Oxford researchers found a positive relationship when it comes to fiber, unlike sugar intake: Consuming 5 grams of fiber a day was associated with a 4% lower risk of heart disease, the study suggested, although that did not hold true when researchers controlled for participants' body-mass indexes.... Watling said, the study demonstrates that the types of carbs people choose to eat may matter more than the total amount. "What's really important for overall general health and well-being is that we're consuming carbohydrates that are rich in whole grains," he said, while "minimizing the consumption of sugar-sweetened beverages, as well any kind of confectionary products that have added sugars."
It's a point underscored by CNN: After over nine years of follow-up, the researchers found total carbohydrate intake wasn't associated with cardiovascular disease. But when they analyzed how outcomes differed depending on the types and sources of carbohydrates eaten, they found higher free sugar intake was associated with a higher risk for cardiovascular disease and greater waist circumference. The more free sugars some participants consumed, the greater their risk of cardiovascular disease, heart disease and stroke was....

"This study provides much needed nuance to public health discussions about the health effects of dietary carbohydrates," said Dr. Maya Adam, director of Health Media Innovation and clinical assistant professor of pediatrics at Stanford University School of Medicine, via email. Adam wasn't involved in the study. "The main takeaways are that all carbs are not created equal...."
CNN adds that the mechanism seems to be that sugar intake "can promote inflammation," according to an assistant cardiology professor at Columbia's medical center. "This can cause stress on the heart and blood vessels, which can lead to increased blood pressure..."

"Moderna will keep its COVID vaccine on the market at no cost to consumers," reports ABC News, "even after the federal government stops paying for it, the company announced Wednesday." "Everyone in the United States will have access to Moderna's COVID-19 vaccine regardless of their ability to pay," the company said in a statement.

Last month, the vaccine maker was slammed for reportedly considering a dramatic price increase for the shot, which it had developed with the help of the federal government. The proposal was also bad timing: The Biden administration was moving toward ending its designation of a public health emergency on May 11, which meant that federal funding for vaccines would soon dry up and uninsured Americans would have to pay out of pocket for their boosters....

Now, Moderna will be the sole manufacturer of COVID vaccines offering its shot for free to the uninsured. Under federal regulation, insurance companies are already required to foot the bill for COVID vaccines.

An anonymous reader quotes a report from Gizmodo: A team of engineers studying the 500-year-old, backward writings of Leonardo da Vinci have found evidence that the Italian polymath was working out gravity a century before its foundations were established by Galileo Galilei. The team's findings come from a revisit of the Codex Arundel, a compilation of documents written by da Vinci that detail various experiments and personal notes taken down in the latter 40 years of his life. The codex is freely accessible online courtesy of the British Museum. The team's research is published in the MIT Press journal Leonardo. Mory Gharib, an engineer at Caltech, said he stumbled across the writings in 2017 when looking for some of da Vinci's work on flow in hearts. Though the codex was written over a long span of da Vinci's later years, Gharib suspects the gravitational musings were written sometime in the last 15-or-so years of his life. Gharib recruited co-author Flavio Noca, a researcher at the University of Applied Sciences and Arts Western Switzerland, to translate the Italian's backward writing on the subject.

Da Vinci understood some fundamentals of objects in motion. He wanted to make an experiment testing how the motion of a cloud would correspond to the hail it produced, if the cloud's velocity and any changes to it corresponded with the falling hail's velocity. In lieu of control of the weather, da Vinci substituted a pitcher for the cloud and sand or water for the hail. Reliable clocks weren't available until about 140 years after da Vinci's death in 1519, the researchers note, so the inventor was forced to substitute the constant of time with space: by assuming that the time it took each water/sand particle to fall from the pitcher was constant, he just kept the pitcher at the same height throughout the tests. Da Vinci's sketch shows the positions of the falling material over the course of its trajectory toward the ground. By drawing a line through the position of the material at each instance in time, da Vinci realized that a triangle could be formed, with the drawn line being the hypotenuse. By changing the acceleration of the pitcher over the course of the experiment, one would change the shape of the triangle. Leonardo knew that the falling material would accelerate and that the acceleration is downward. What he wasn't wholly certain on -- hence the experiment -- was the relationship between the falling material's acceleration and the pitcher's acceleration.

In one particular case, when the pitcher's motion was accelerated to the same rate as the falling material being affected by gravity, an equilateral triangle was formed. Literally, as Da Vinci noted, an "Equatione di Moti" or an "equalization of motions." The researchers modeled da Vinci's experiment and found that the polymath was wrong in his understanding of the relationship between the falling object and time. "What we saw is that Leonardo wrestled with this, but he modeled it as the falling object's distance was proportional to 2 to the t power [with t representing time] instead proportional to t squared," said Chris Roh, a researcher at Cornell University and a co-author of the researcher, in a Caltech release. "It's wrong, but we later found out that he used this sort of wrong equation in the correct way." The team interpreted tick marks on da Vinci's sketches as data points the polymath made based on his eyeballing of the experiment in action. In lieu of a timepiece, da Vinci found the gravitational constant to nearly 98% accuracy.

Scientists from China's Hebei University of Science and Technology have developed an ice-melting additive for asphalt that could remain active for years. New Atlas reports: [The researchers started] out by developing a chloride-free acetate-based salt. Such salts are considerably less environmentally harmful than chlorides, they're less corrosive to steel and other materials, plus they work at lower temperatures. The researchers proceeded to mix the salt with a surfactant, silicon dioxide, sodium bicarbonate and blast furnace slag (which has also been used in salt-proof concrete), resulting in a fine powder. Particles of that powder were then coated with a polymer solution, producing microcapsules. Finally, the scientists replaced some of the mineral filler in a conventional asphalt mixture with those capsules.

When the special asphalt was tested on the off-ramp of a highway, it was found not only to continuously melt the snow that fell upon it, but also to lower the freezing point of water from 0C (32F) down to -21C (-6F). What's more, based on lab tests, the researchers estimate that a 5-cm (2-in)-thick slab of the pavement would continue to release its salt capsules for seven to eight years, keeping the road clear that whole time. The study was recently published in the journal ACS Omega.

A 19-month-old girl named Teddi recently became the first child in the U.K. outside a clinical trial to receive a new gene therapy for metachromatic leukodystrophy (MLD), a fatal genetic disorder, the National Health Service (NHS) announced. Roughly six months out from treatment, "Teddi is a happy and healthy toddler showing no signs of the devastating disease she was born with," the NHS statement reads. Live Science reports: The genetic disorder MLD disrupts cells' ability to break down sulfatides, a fatty material used to insulate the wiring that runs through the white matter of the brain and much of the nervous system beyond the brain. Sulfatide buildup destroys brain and nerve cells, resulting in cognitive problems, a loss of motor control and sensation, seizures, paralysis and blindness, according to the Genetic and Rare Diseases Information Center. Eventually, the disorder leads to death. [...]

The new gene therapy, called Libmeldy (generic name atidarsagene autotemcel), was only recently cleared for use by the NHS and works by inserting into the body working copies of the genes that are faulty in MLD, thus restoring the ability to break down sulfatides. Libmeldy is made using stem cells that are derived from a patient's blood or bone marrow and can give rise to different types of blood cells, according to the European Medicines Agency (EMA). These stem cells carry the new, functional genes into the body, where they give rise to white blood cells that travel through the bloodstream. In clinical trials, Libmeldy offered clear benefits to infantile and juvenile patients who hadn't yet developed MLD symptoms; these patients were able to break down sulfatides at normal rates and showed typical patterns of motor development, for example. The benefit of the therapy seemed to last several years, but at this point, "it is not yet clear whether it will persist life-long, and extended follow-up is needed," the EMA noted.

An anonymous reader quotes a report from Ars Technica: New data suggests that psychedelics may activate serotonin signaling in a very different way than serotonin itself can, reaching the receptors in parts of the cell that serotonin can't get to. Serotonin signaling is complicated. There are seven classes of receptors in humans; some activate signaling pathways, while others inhibit them. One group of receptors allows ions into a cell in response to serotonin, triggering nerve impulses. The rest interact with proteins inside the cell, triggering longer-term responses to serotonin. Psychedelics such as LSD and mescaline bind to members of this latter group and activate it.

This action produces some rather dramatic changes in how people perceive their surroundings. But there's also some evidence that psychedelics promote changes to nerve cells that allow these cells to alter their connectivity. This occurs by causing the structures that receive input from other nerve cells, called dendrites, to grow and branch, potentially allowing additional or altered inputs. One hypothesis is that this altered connectivity allows cells to escape whatever network configuration has been associated with a medical disorder. The researchers confirmed these results using DMT, a psychedelic found in ayahuasca, and psilocin, the active form of the drug psilocybin, which is typically obtained from mushrooms. Twenty-four hours after mice received one of these drugs, nerve cells in their brains had an increased density of extensions from their dendrites. This growth was accompanied by an increased frequency of activity in individual nerve cells. Running the same tests in mice that lacked the gene for the specific serotonin receptor that these drugs target blocked both of these effects, confirming that serotonin signaling is central to the changes.

The researchers then started testing close chemical relatives of the drugs and saw a clear pattern: Making the drug less likely to interact with water boosted their effects on neurons. This suggested that the ability to cross membranes, which are very water-repellant, might be needed to promote changes in dendrites. To confirm this, the researchers poked holes in the membranes, which boosted the activity of water-friendly drug variants that wouldn't readily cross the membrane. This is all a bit confusing because the serotonin receptors sit inside the membrane and interact with the cell's exterior. They have to -- that's where the serotonin is. So why would anything that interacted with those receptors need to cross a membrane to the cell's interior? The receptors on the cell's surface are definitely key to the cell's response to serotonin. But the receptors don't just magically appear on the cell's surface -- they're made elsewhere in the cell and take a while to be processed and transported to the surface. The researchers found a population of serotonin receptors sitting inside a structure called the Golgi. It's not clear whether this population is simply on its way to the cell surface or whether it's retained there by some specific biological activity. Normally, these receptors wouldn't come into contact with serotonin, so they wouldn't signal from this location. But the researchers modified a protein to make it pump serotonin inside of cells and showed that it had the same effect the psychedelics had, suggesting the receptors could be activated and that this activation was key to altering neural connectivity. The study has been published in the journal Science.

The oceans soak up enormous quantities of carbon dioxide, and MIT researchers say they've developed a way of releasing and capturing it that uses far less energy than direct air capture -- with some other environmental benefits to boot. New Atlas reports: According to IEA figures from 2022, even the more efficient air capture technologies require about 6.6 gigajoules of energy, or 1.83 megawatt-hours per ton of carbon dioxide captured. Most of that energy isn't used to directly separate the CO2 from the air, it's in heat energy to keep the absorbers at operating temperatures, or electrical energy used to compress large amounts of air to the point where the capture operation can be done efficiently. But either way, the costs are out of control, with 2030 price estimates per ton ranging between US$300-$1,000. According to Statista, there's not a nation on Earth currently willing to tax carbon emitters even half of the lower estimate; first-placed Uruguay taxes it at US$137/ton. Direct air capture is not going to work as a business unless its costs come way down.

It turns out there's another option: seawater. As atmospheric carbon concentrations rise, carbon dioxide begins to dissolve into seawater. The ocean currently soaks up some 30-40% of all humanity's annual carbon emissions, and maintains a constant free exchange with the air. Suck the carbon out of the seawater, and it'll suck more out of the air to re-balance the concentrations. Best of all, the concentration of carbon dioxide in seawater is more than 100 times greater than in air. Previous research teams have managed to release CO2 from seawater and capture it, but their methods have required expensive membranes and a constant supply of chemicals to keep the reactions going. MIT's team, on the other hand, has announced the successful testing of a system that uses neither, and requires vastly less energy than air capture methods.

In the new system, seawater is passed through two chambers. The first uses reactive electrodes to release protons into the seawater, which acidifies the water, turning dissolved inorganic bicarbonates into carbon dioxide gas, which bubbles out and is collected using a vacuum. Then the water's pushed through to a second set of cells with a reversed voltage, calling those protons back in and turning the acidic water back to alkaline before releasing it back into the sea. Periodically, when the active electrode is depleted of protons, the polarity of the voltage is reversed, and the same reaction continues with water flowing in the opposite direction. In a new study published in the peer-reviewed journal Energy & Environmental Science, the team says its technique requires an energy input of 122 kJ/mol, equating by our math to 0.77 mWh per ton. And the team is confident it can do even better: "Though our base energy consumption of 122 kJ/mol-CO2 is a record-low," reads the study, "it may still be substantially decreased towards the thermodynamic limit of 32 kJ/mol-CO2."

For those of us who struggle to leave our beds in the winter, taunts of "lazy" could well be misplaced. From a report: New research suggests that while humans do not hibernate, we may need more sleep during the colder months. Analysis of people undergoing sleep studies found that people get more REM (rapid eye movement) sleep in the winter. While total sleep time appeared to be about an hour longer in the winter than the summer, this result was not considered statistically significant.

However, REM sleep -- known to be directly linked to the circadian clock, which is affected by changing light -- was 30 minutes longer in the winter than in summer. The research suggests that even in an urban population experiencing disrupted sleep, humans experience longer REM sleep in winter than summer and less deep sleep in autumn. Researchers say if the study's findings can be replicated in people with healthy sleep, this would provide the first evidence for a need to adjust sleep habits to season -- perhaps by going to sleep earlier in the darker and colder months.

New submitter kalieaire writes: Steve Trimble of Aviation week reports that a Hobby Club's missing ballon might have been inadvertently targeted as a malicious UFO and subsequently shot down. When Scientific Balloon Solutions (SBS) company founder, Ron Meadows, reached out to Gov't resources at the FBI and DoD, they were brushed off. "I'm guessing probably they were pico balloons," said Tom Medlin, a retired FedEx engineer and co-host of the Amateur Radio Roundtable show. Merlin has three pico balloons in flight in the Northern and Southern hemispheres. According to Trimble, the description of all three UFOs shot down during 2/10-12 match the description of pico balloon models which can be purchased for $12-180 each, depending on the type. "Launching high-altitude, circumnavigational pico balloons has emerged only within the past decade," writes Trimble. He continues: Meadows and his son Lee discovered it was possible to calculate the amount of helium gas necessary to make a common latex balloon neutrally buoyant at altitudes above 43,000 ft. The balloons carry an 11-gram tracker on a tether, along with HF and VHF/UHF antennas to update their positions to ham radio receivers around the world. At any given moment, several dozen such balloons are aloft, with some circling the globe several times before they malfunction or fail for other reasons. The launch teams seldom recover their balloons.

The balloons can come in several forms. Some enthusiasts still use common, Mylar party balloons, with a set of published calculations to determine the amount of gas to inject. But the round-shaped Mylar balloons often are unable to ascend higher than 20,000-30,000 ft., so some pico balloonists have upgraded to different materials. [...] In fact, the pico balloons weigh less than 6 lb. and therefore are exempt from most FAA airspace restrictions, Meadows and Medlin said. Three countries -- North Korea, Yemen and the UK -- restrict transmissions from balloons in their airspace, so the community has integrated geofencing software into the tracking devices. The balloons still overfly the countries, but do not transmit their positions over their airspace. On Feb. 15, NSC spokesman John Kirby told reporters all three objects "could just be balloons tied to some commercial or benign purpose," but he did not mention the possibility of pico balloons.

Genetically modified seedlings from biotechnology company Living Carbon have been planted in a low-lying tract of southern Georgia's pine belt. According to a paper that has yet to be peer reviewed, these trees are engineered to grow 50 percent faster than non-modified ones over five months in the greenhouse. The New York Times reports: The poplars may be the first genetically modified trees planted in the United States outside of a research trial or a commercial fruit orchard. Just as the introduction of the Flavr Savr tomato in 1994 introduced a new industry of genetically modified food crops, the tree planters on Monday hope to transform forestry. Living Carbon, a San Francisco-based biotechnology company that produced the poplars, intends for its trees to be a large-scale solution to climate change. "We've had people tell us it's impossible," Maddie Hall, the company's co-founder and chief executive, said of her dream to deploy genetic engineering on behalf of the climate. But she and her colleagues have also found believers -- enough to invest $36 million in the four-year-old company.

The company's researchers created the greenhouse-tested trees using a bacterium that splices foreign DNA into another organism's genome. But for the trees they planted in Georgia, they turned to an older and cruder technique known as the gene gun method, which essentially blasts foreign genes into the trees' chromosomes. In a field accustomed to glacial progress and heavy regulation, Living Carbon has moved fast and freely. The gene gun-modified poplars avoided a set of federal regulations of genetically modified organisms that can stall biotech projects for years. (Those regulations have since been revised.) By contrast, a team of scientists who genetically engineered a blight-resistant chestnut tree using the same bacterium method employed earlier by Living Carbon have been awaiting a decision since 2020. [...]

In contrast to fast-growing pines, hardwoods that grow in bottomlands like these produce wood so slowly that a landowner might get only one harvest in a lifetime, said [Vince Stanley, a seventh-generation farmer who manages more than 25,000 forested acres in Georgia's pine belt]. He hopes Living Carbon's "elite seedlings" will allow him to grow bottomland trees and make money faster. "We're taking a timber rotation of 50 to 60 years and we're cutting that in half," he said. "It's totally a win-win." [...] The U.S. Forest Service, which plants large numbers of trees every year, has said little about whether it would use engineered trees. To be considered for planting in national forests, which make up nearly a fifth of U.S. forestland, Living Carbon's trees would need to align with existing management plans that typically prioritize forest health and diversity over reducing the amount of atmospheric carbon, said Dana Nelson, a geneticist with the service. "I find it hard to imagine that it would be a good fit on a national forest," Dr. Nelson said. Living Carbon is focusing for now on private land, where it will face fewer hurdles. Later this spring it will plant poplars on abandoned coal mines in Pennsylvania. By next year Ms. Hall and Mr. Mellor hope to be putting millions of trees in the ground. The report notes that the modified trees are all female, "so they won't produce pollen."

"They're also being planted alongside native trees like sweet gum, tulip trees and bald cypress, to avoid genetically identical stands of trees known as monocultures; non-engineered poplars are being planted as experimental controls."

An anonymous reader quotes a report from Phys.Org: A new paper in Annals of Botany indicates that watching nature documentaries makes people more interested in plants, potentially provoking an involvement in botany and ecology. [T]he researchers investigated whether nature documentaries can promote plant awareness, which may ultimately increase audience engagement with plant conservation programs. They focused on "Green Planet," a 2022 BBC documentary narrated by Sir David Attenborough. The show, watched by nearly 5 million people in the United Kingdom, featured a diversity of plant species, highlighting vegetation from tropical rainforests, aquatic environments, seasonal lands, deserts, and urban spaces. The program also addressed environmental concerns directly, examining the dangers of invasive monocultures and deforestation.

The researchers measured whether "Green Planet" drove interest in the plants by exploring people's online behavior around the time of the broadcast. First, they noted the species that appeared on the show and the time each one appeared on-screen. Then they extracted Google Trends and Wikipedia page hits for those same species before and after the episodes of the documentary aired. The researchers here found a substantial effect of "Green Planet" on viewers' awareness and interest in the portrayed plant species. Some 28.1% of search terms representing plants mentioned in the BBC documentary had peak popularity in the UK, measured using Google Trends, the week after the broadcast of the relevant episode. Wikipedia data showed this as well. Almost a third (31.3%) of the Wikipedia pages related to plants mentioned in "Green Planet" showed increased visits the week after the broadcast. The investigators also note that people were more likely to do online searches for plants that enjoyed more screen time on "Green Planet." "I think that increasing public awareness of plants is essential and fascinating," said the paper's lead author, Joanna Kacprzyk. "In this study, we show that nature documentaries can increase plant awareness among the audience. Our results also suggest that the viewers found certain plant species particularly captivating. These plants could be used for promoting plant conservation efforts and counteracting the alarming loss of plant biodiversity."

Observations of supermassive black holes at the centers of galaxies point to a likely source of dark energy -- the 'missing' 70% of the universe. Phys.Org reports: The measurements from ancient and dormant galaxies show black holes growing more than expected, aligning with a phenomenon predicted in Einstein's theory of gravity. The result potentially means nothing new has to be added to our picture of the universe to account for dark energy: black holes combined with Einstein's gravity are the source. The conclusion was reached by a team of 17 researchers in nine countries, led by the University of Hawai'i and including Imperial College London and STFC RAL Space physicists. The work is published in two papers in the journals The Astrophysical Journal and The Astrophysical Journal Letters.

The conclusion was made by studying nine billion years of black hole evolution. [...] The researchers looked at a particular type of galaxy called giant elliptical galaxies, which evolved early in the universe and then became dormant. Dormant galaxies have finished forming stars, leaving little material for the black hole at their center to accrete, meaning any further growth cannot be explained by these normal astrophysical processes. Comparing observations of distant galaxies (when they were young) with local elliptical galaxies (which are old and dead) showed growth much larger than predicted by accretion or mergers: the black holes of today are 7-20 times larger than they were nine billion years ago.

Further measurements with related populations of galaxies at different points in the universe's evolution show good agreement between the size of the universe and the mass of the black holes. These show that the measured amount of dark energy in the universe can be accounted for by black hole vacuum energy. This is the first observational evidence that black holes actually contain vacuum energy and that they are 'coupled' to the expansion of the universe, increasing in mass as the universe expands -- a phenomenon called 'cosmological coupling.' If further observations confirm it, cosmological coupling will redefine our understanding of what a black hole is.

The idea of using dirt on the Moon to manufacture solar cells, which could power a permanent human settlement, may seem outlandish, but two companies say they've made big progress on that front: they each say they've already made solar cells using fake Moon dirt. From a report: Jeff Bezos' company Blue Origin says it's been making solar cells this way since 2021 but just made that information public in a blog post on Friday. Separately, Lunar Resources, which aims to develop technologies for the "large-scale industrialization of Space," told The Verge in a call today that it's been doing the same for the last couple of years. Each company still has to make an enormous leap: from crafting solar cells out of fake dirt in Earth-bound labs to accomplishing the same thing on the harsh surface of the Moon. But this is a dream decades in the making. And if their technologies succeed, they could help make it possible to build outposts on the Moon. The idea of tapping the Moon's resources to support human settlements, called in-situ resource utilization (ISRU) in technical speak, has only recently moved out of the realm of science fiction. Now, with its Artemis program, NASA is looking to establish "the first long-term presence on the Moon."

Glaxo says the heartburn drug doesn't cause tumors. But the company was warned by its own scientists and independent researchers about the potential danger. From a report: The small British company was sometimes called Glaxo University, because it conducted important pharmaceutical research that rarely resulted in profitable drugs. Then the scientists at Glaxo Laboratories created a molecule they called ranitidine, and in 1978 the company was granted a US patent. The molecule was new, but not novel. The scientists had, as scientists sometimes do, looked for a way to mimic the success of an established drug -- in this case, one that healed ulcers and could be used to treat heartburn. They developed ranitidine quickly, and the US Food and Drug Administration reviewed it quickly. Glaxo gave it the brand name Zantac. Glaxo marketed it as better and safer than the drug that inspired it, Tagamet, and before long, Zantac overtook Tagamet to become the world's bestselling prescription medication. For years, Glaxo counted on Zantac for nearly half of its sales and almost as much of its profit. The company won an award from Queen Elizabeth; the chief executive officer was knighted. Zantac created reputations and fortunes. It financed the modern version of Glaxo, which, after mergers and takeovers and spinoffs, ended up as GSK, a company now worth some $73 billion. Among its most popular drugs are the antidepressants Paxil and Wellbutrin and the shingles vaccine Shingrix.

But not Zantac. In 2019 the drug was found to be tainted with high levels of a probable carcinogen. Not by chance or mistake in a few batches. The poison is created by ranitidine itself. Zantac's makers and health regulators around the world recalled the drug, and in the spring of 2020 the FDA forced it off the market altogether. No company could manufacture it; nobody should ingest it. The carcinogen, called NDMA, was once added to rocket fuel and is now used only to induce cancer in lab rats. The FDA says consuming minuscule amounts isn't harmful. But tests were revealing excessive amounts of NDMA in ranitidine -- and a capacity to create even more over time. No version seemed safe. From ranitidine's beginning to its end, Glaxo had been warned by its own scientists and independent researchers about the potential danger. An account of those four decades emerges in hundreds of documents, thousands of pages, many of which have never been made public. Bloomberg Businessweek reviewed court filings, many still under seal, as well as studies, FDA transcripts and new drug applications obtained via Freedom of Information Act requests. They show that the FDA considered the cancer risks when approving ranitidine. But Glaxo didn't share a critical study. Over the years, the company also backed flawed research designed to minimize concerns and chose not to routinely transport and store the medication in ways that could have eased the problem. Glaxo sold a drug that might harm people, tried to discount evidence of that and never gave anyone the slightest warning. More than 70,000 people who took Zantac or generic versions of it are suing the company in US state courts for selling a potentially contaminated and dangerous drug.

An anonymous reader quotes a report from the Wall Street Journal: A drug aimed at treating eyes immobilized sperm and prevented pregnancy in mice, encouraging researchers that it might work as a contraceptive for men. Injected into male mice, the drug was 100% effective in preventing pregnancy for 2 1/2 hours and about 91% effective for up to 3 1/2 hours, according to a study published Tuesday in the journal Nature Communications. The male mice were fertile after a day, the study found. The new approach is appealing for how quickly the contraceptive acts. The researchers said they would test the drug in other animals and aim for human trials in the coming years.

The drug presented in Tuesday's study acts by deactivating an enzyme in mice and men that make sperm swim. "It's like your on-switch on your TV," said Jochen Buck, a pharmacologist at Weill Cornell Medicine, an author of the study. When the researchers added the drug to human and mice sperm in a dish, the cells stopped moving temporarily. Lower doses of the drug resulted in progressively more mobile sperm cells, Dr. Buck said. The drug took about 15 minutes to take effect. Male mice injected with the drug didn't alter their mating behavior. Allowed to mate in the 2.5 hours after injection, none of 52 pairs of mice produced offspring. A third of mice partners in a control group of 50 had pregnancies. Mice given the drug were later able to father healthy pups, the study said.