Scientists have successfully treated a 9.5-month-old boy with an ultra-rare genetic disorder using the world's first personalized gene-editing therapy. The patient, identified as KJ, has CPS1 deficiency -- a condition affecting just one in 1.3 million babies that prevents proper ammonia processing and is often fatal.

The breakthrough treatment, detailed in the New England Journal of Medicine, uses base editing technology to correct KJ's specific DNA mutation. The therapy delivers CRISPR components wrapped in fatty lipid molecules that protect them in the bloodstream until they reach liver cells, where they make the precise edit needed.

After three infusions, KJ now eats normal amounts of protein and has maintained stable ammonia levels even through viral illnesses that would typically cause dangerous spikes. His weight has increased from the 7th to 40th percentile. Dr. Peter Marks, former FDA official, called the approach "one of the most potentially transformational technologies" because it could be rapidly adapted for thousands of other rare genetic diseases without lengthy development cycles.

Montana has passed a bill allowing licensed clinics to offer experimental medical treatments that haven't been approved by the FDA, provided the drugs have passed phase I safety trials. MIT Technology Review reports: The bill, which was passed by the state legislature on April 29 and is expected to be signed by Governor Greg Gianforte, essentially expands on existing Right to Try legislation in the state. But while that law was originally designed to allow terminally ill people to access experimental drugs, the new bill was drafted and lobbied for by people interested in extending human lifespans -- a group of longevity enthusiasts that includes scientists, libertarians, and influencers. These longevity enthusiasts are hoping Montana will serve as a test bed for opening up access to experimental drugs. [...]

Supporters of the bill say it gives individuals the freedom to make choices about their own bodies. At the same event, bioethicist Jessica Flanigan of the University of Richmond said she was "optimistic" about the measure, because "it's great any time anybody is trying to give people back their medical autonomy." Ultimately, they hope that the new law will enable people to try unproven drugs that might help them live longer, make it easier for Americans to try experimental treatments without having to travel abroad, and potentially turn Montana into a medical tourism hub.

But ethicists and legal scholars aren't as optimistic. "I hate it," bioethicist Alison Bateman-House of New York University says of the bill. She and others are worried about the ethics of promoting and selling unproven treatments -- and the risks of harm should something go wrong. [...] At any rate, the clinics are coming to Montana, says [Dylan Livingston, founder and CEO of the Alliance for Longevity Initiatives]. "We have half a dozen that are interested, and maybe two or three that are definitively going to set up shop out there." He won't name names, but he says some of the interested clinicians already have clinics in the US, while others are abroad."

Mac Davis -- founder and CEO of Minicircle, the company that developed the controversial "anti-aging" gene therapy -- told MIT Technology Review he was "looking into it." "I think this can be an opportunity for America and Montana to really kind of corner the market when it comes to medical tourism," says Livingston. "There is no other place in the world with this sort of regulatory environment."

Longtime Slashdot reader ndsurvivor shares a report from TechCrunch: In 2018, Liangbing Hu, a materials scientist at the University of Maryland, devised a way to turn ordinary wood into a material stronger than steel. It seemed like yet another headline-grabbing discovery that wouldn't make it out of the lab. "All these people came to him," said Alex Lau, CEO of InventWood, "He's like, OK, this is amazing, but I'm a university professor. I don't know quite what to do about it."

Rather than give up, Hu spent the next few years refining the technology, reducing the time it took to make the material from more than a week to a few hours. Soon, it was ready to commercialize, and he licensed the technology to InventWood. Now, the startup's first batches of Superwood will be produced starting this summer. "Right now, coming out of this first-of-a-kind commercial plant -- so it's a smaller plant -- we're focused on skin applications," Lau said. "Eventually we want to get to the bones of the building. Ninety percent of the carbon impact from buildings is concrete and steel in the construction of the building." To build the factory, InventWood has raised $15 million in the first close of a Series A round. The round was led by the Grantham Foundation with participation from Baruch Future Ventures, Builders Vision, and Muus Climate Partners, the company exclusively told TechCrunch. How do they do it? According to TechCrunch, InventWood's Superwood is made by treating regular timber with "food industry" chemicals to remove lignin and modify its structure, then compressing it to increase hydrogen bonding between cellulose fibers. This densification makes the wood up to 10 times stronger than natural wood, with a higher strength-to-weight ratio than steel. "You end up with something that looks like these richer, tropical hardwoods," Lau added.

An anonymous reader quotes a report from the BBC: A student's robot has beaten the world record for solving a four-by-four Rubik's cube -- by 33 seconds. Matthew Pidden, a 22-year-old University of Bristol student, built and trained the "Revenger" over 15 weeks for his computer science bachelor's degree. The robot solved the cube in 45.305 seconds, obliterating the world record of 1 minute 18 seconds. However, the human record for solving the cube is 15.71 seconds.

Mr Pidden's robot uses dual webcams to scan the cube, a custom mechanism to manipulate the faces, and a fully self-built solving algorithm to generate efficient solutions. The student now plans to study for a master's degree in robotics at Imperial College London.

Dutch researchers have recalculated the timeline for cosmic decay via Hawking-like radiation and found that the universe may end much sooner than previously thought -- around 10^78 years, rather than 10^1100. Phys.Org reports: The research by black hole expert Heino Falcke, quantum physicist Michael Wondrak, and mathematician Walter van Suijlekom (all from Radboud University, Nijmegen, the Netherlands) is a follow-up to a 2023 paper by the same trio. In that paper, they showed that not only black holes, but also other objects such as neutron stars, can "evaporate" via a process akin to Hawking radiation. After that publication, the researchers received many questions from inside and outside the scientific community about how long the process would take. They have now answered this question in the new article.

The researchers calculated that the end of the universe is about 10^78 years away, if only Hawking-like radiation is taken into account. This is the time it takes for white dwarf stars, the most persistent celestial bodies, to decay via Hawking-like radiation. Previous studies, which did not take this effect into account, put the lifetime of white dwarfs at 10^1100 years. Lead author Heino Falcke said, "So the ultimate end of the universe comes much sooner than expected, but fortunately it still takes a very long time." The findings have been published in the Journal of Cosmology and Astroparticle Physics.

Evidence is mounting for "a vast reservoir of liquid water" on Mars, according to a new article by Australian National University professor Hrvoje TkalÄiÄ and geophysics associate professor Weijia Sun from the Chinese Academy of Geological Sciences, announcing their recently published paper.

"Using seismic data from NASA's InSight mission, we uncovered evidence that the seismic waves slow down in a layer between 5.4 and 8 kilometres below the surface, which could be because of the presence of liquid water at these depths." Mars is covered in traces of ancient bodies of water. But the puzzle of exactly where it all went when the planet turned cold and dry has long intrigued scientists... Billions of years ago, during the Noachian and Hesperian periods (4.1 billion to 3 billion years ago), rivers carved valleys and lakes shimmered. As Mars' magnetic field faded and its atmosphere thinned, most surface water vanished. Some escaped to space, some froze in polar caps, and some was trapped in minerals, where it remains today. But evaporation, freezing and rocks can't quite account for all the water that must have covered Mars in the distant past.

Calculations suggest the "missing" water is enough to cover the planet in an ocean at least 700 metres deep, and perhaps up to 900 metres deep. One hypothesis has been that the missing water seeped into the crust. Mars was heavily bombarded by meteorites during the Noachian period, which may have formed fractures that channelled water underground. Deep beneath the surface, warmer temperatures would keep the water in a liquid state — unlike the frozen layers nearer the surface.

In 2018, NASA's InSight lander touched down on Mars to listen to the planet's interior with a super-sensitive seismometer. By studying a particular kind of vibration called "shear waves", we found a significant underground anomaly: a layer between 5.4 and 8 kilometres down where these vibrations move more slowly. This "low-velocity layer" is most likely highly porous rock filled with liquid water, like a saturated sponge. Something like Earth's aquifers, where groundwater seeps into rock pores. We calculated the "aquifer layer" on Mars could hold enough water to cover the planet in a global ocean 520-780m deep.
InSight's seismometer captured vibrations between the crust of Mars and its lower layers from two meteorite impacts in 2021 and a Marsquake in 2022. "These signatures let us pinpoint boundaries where rock changes, revealing the water-soaked layer 5.4 to 8 kilometres deep."

It's an exciting possibility. "Purified, it could provide drinking water, oxygen, or fuel for rockets." And since microbes thrives on earth in deep rocks filled with water, "Could similar life, perhaps relics of ancient Martian ecosystems, persist in these reservoirs?"

18 years ago Slashdot covered the creation of Spaceport America.

Today Space.com hails it as "the first purpose-built commercial spaceport in the world." But engineer/executive director Scott McLaughlin has plans to grow even more. Already home to an array of commercial space industry tenants, such as Virgin Galactic, SpinLaunch, Up Aerospace, and Prismatic, Spaceport America is a "rocket-friendly environment of 6,000 square miles of restricted airspace, low population density, a 12,000-foot by 200-foot runway, vertical launch complexes, and about 340 days of sunshine and low humidity," the organization boasts on its website...

Space.com: What changes do you see that make Spaceport America even more viable today?

McLaughlin: I think opening ourselves up to doing different kinds of work. We're more like a civilian test range now. We've got high-altitude UAVs [Unmanned Aerial Vehicles]. We're willing to do engine production. We believe we're about to sign a data center, one that's able to provide services to our customers who want low-latency, artificial intelligence, or high-powered computing. You'll be able to rent some virtual machines and do your own thing and have it be instantaneous at the spaceport. So I think being more broadminded about what we can do at the spaceport is helping generate customers and revenue...

Our goal is to see Virgin Galactic fly in a year or so, hopefully flying twice a week, and that will have a big impact on the spaceport... [W]e're trying to be open-minded as we're partnered with White Sands Missile Range to use that airspace. We're even looking at things like an electromagnetic pulse facility. It's a customer that I can't identify yet... We are working on a "reentry" license too. We recently discussed this with specialists and we think we have a site relatively close to the spaceport that's flat and free of mesquite bushes and such, so we can do capsule return and other types of return. And of course we have the runway. So I'd think we'd be the only spaceport that does vertical and horizontal launch and reentry....

We're never going to have the throughput that the Cape in Florida has. But we'll be a good alternative especially if you're going to do a small to medium-sized launch, and you need to do it quickly, and perhaps do it more securely than you would if you were to fly over water. That's why the Department of Defense is showing interest in the inland spaceport.

"The romantic partner of Theranos fraudster Elizabeth Holmes has launched a start-up that sounds eerily similar to the venture that landed his girlfriend behind bars," writes The Daily Beast.

He's incorporated "Haemanthus" in Delaware a year and a half ago (though the company operates out of his neighborhood in Austin), according to the New York Times. Haemanthus appears to have around 10 employees.

From The Daily Beast: California hotel heir Billy Evans' new company is a blood-testing firm that markets itself as "the future of diagnostics," offering "a radically new approach to health testing," according to The New York Times. In other words, exactly what Theranos said it would do. Holmes is even advising the start-up from the Texas prison where she is serving out an 11-year prison sentence for fraud, sources told NPR... Evans has managed to raise nearly $20 million in funds from both friends and established investors in Austin and San Francisco, according to the investor materials.
The Times reports that Evan's company "plans to begin with testing pets for diseases before progressing to humans, according to two investors pitched on the company."

And TechCrunch reminds readers that Elizabeth Holmes said in a recent interview "that she remains 'completely committed to my dream of making affordable healthcare solutions available to everyone.'"

Elizabeth Holmes has lost her bid to have the appeal of her 2022 fraud conviction reheard by the 9th Circuit Court of Appeals, leaving the U.S. Supreme Court as her final option. She and former Theranos executive Sunny Balwani remain liable for $452 million in restitution, while Holmes continues serving her 11-year sentence. CNBC reports: The 9th Circuit U.S. Court of Appeals denied Holmes' request for a rehearing before the original three-judge panel that upheld her conviction. At the same time, the court said no judge on the circuit court had asked for a vote on whether to have the full court rehear the appeal.

Holmes, 41, was sentenced in January 2023 to 11 years and 3 months in prison after being found guilty of four counts of wire fraud in January 2022. She was found guilty of deceiving investors about the capabilities of Theranos, the blood-testing company she founded in 2003. The company crumbled after a Wall Street Journal story outlined the firm's struggles and shut down in 2018.

sciencehabit shares a repot from Science.org: Scientists have captured fungal spores cruising in the inhospitable environment of the stratosphere, much higher than commercial aircraft fly. When brought back to the lab, the researchers found that some of the spores -- including pathogens of plants and people -- had survived intercontinental trips and could be cultured in the lab. Although spores and microbes have been detected in the stratosphere before, the new results come from a cheap, homespun sampling device dangled from weather balloons, the project could help researchers figure out what traits and conditions allow spores to survive a swing through the stratosphere and how they get up there in the first place. The work could also be a first step towards an atmospheric monitoring system that could nip emerging fungal pathogens in the bud, the study's authors reported at a conference of the European Geophysical Union.

After five preliminary flights, the team has already learned a lot. Based on DNA sequencing analysis, they identified spores from 235 genera, including fungi that infect blackberries and carrots in the United States and Japan, and one species, Naganishia albida, that can make immunocompromised people sick. In the lab, they were able to revive and culture spores from 15 different fungal species, among them several plant pathogens. Mostly, the results show that their sampler works. Now, the researchers want to set up regular flights to track airborne fungal biodiversity and seasonal variations. They also want to identify how events such as wildfires or volcanic eruptions inject spores into the stratosphere.

Researchers have discovered a mutation in the SIK3 gene that enables some people to function normally on just three to six hours of sleep. The finding, published this week in PNAS, adds to a growing list of genetic variants linked to naturally short sleepers.

When University of California, San Francisco scientists introduced the mutation to mice, the animals required 31 minutes less sleep daily. The modified enzyme showed highest activity in brain synapses, suggesting it might support brain homeostasis -- the resetting process thought to occur during sleep.

"These people, all these functions our bodies are doing while we are sleeping, they can just perform at a higher level than we can," said Ying-Hui Fu, the study's co-author. This marks the fifth mutation across four genes identified in naturally short sleepers. Fu's team hopes these discoveries could eventually lead to treatments for sleep disorders by revealing how sleep regulation functions in humans.

An anonymous reader quotes a report from the Associated Press: The European Union launched a drive on Monday to attract scientists and researchers to Europe with offers of grants and new policy plans, after the Trump administration froze U.S. government funding linked to diversity, equity and inclusion initiatives. "A few years ago, no one would have imagined that one of the biggest democracies in the world would cancel research programs under the pretext that the word diversity was in this program," French President Emmanuel Macron said at the "Choose Europe for Science" event in Paris. "No one would have thought that one of the biggest democracies in the world would delete with a stroke the ability of one researcher or another to obtain visas," Macron said. "But here we are."

Taking the same stage at the Sorbonne University, European Commission President Ursula von der Leyen said that the EU's executive branch would set up a "super grant" program aimed at offering "a longer-term perspective to the very best" in the field. She said that 500 million euros ($566 million) will be put forward in 2025-2027 "to make Europe a magnet for researchers." It would be injected into the European Research Council, which already has a budget of more than 16 billion euros ($18 billion) for 2021-2027.

Von der Leyen said that the 27-nation EU intends "to enshrine freedom of scientific research into law" with a new legal act. As "the threats rise across the world, Europe will not compromise on its principles," she said. Macron said that the French government would also soon make new proposals to beef up investment in science and research. [...] While not mentioning the Trump administration by name, von der Leyen said that it was "a gigantic miscalculation" to undermine free and open research. "We can all agree that science has no passport, no gender, no ethnicity, no political party," she said. "We believe that diversity is an asset of humanity and the lifeblood of science. It is one of the most valuable global assets and it must be protected." Macron said that science and research must not "be based on the diktats of the few."

Macron said that Europe "must become a refuge" for scientists and researchers, and he said to those who feel under threat elsewhere: "The message is simple. If you like freedom, come and help us to remain free, to do research here, to help us become better, to invest in our future."

Further reading:
75% of Scientists in Nature Poll Weigh Leaving US
NASA, Yale, and Stanford Scientists Consider 'Scientific Exile'

According to the Wall Street Journal, UnitedHealth Group has 1,000 AI applications in production for use in its insurance, health delivery and pharmacy divisions. From a report: UnitedHealth's AI transcribes conversations from clinician visits, summarizes data, processes claims and controls customer-facing chatbots. In addition, roughly 20,000 of the company's engineers use AI to write software, according to the report. Half of these applications use generative AI and the other half employ a more traditional version of the technology, said Chief Digital and Technology Officer Sandeep Dadlani, per the report. "Like other AI-powered tools, medical chatbots are more likely to provide highly accurate answers when thoroughly trained on high-quality, diverse datasets and when user prompts are clear and simple," Julie McGuire, managing director of the BDO Center for Healthcare Excellence & Innovation, told PYMNTS in April 2024. "However, when questions are more complicated or unusual, a medical chatbot may provide insufficient or incorrect answers. In some cases, a generative AI-powered medical chatbot could make up a study to justify a medical answer it wants to give."

Dr. Paul Offit, an expert on infectious disease and immunology, told the Guardian that "We're living in a post-herd-immunity world. I think the measles outbreak proves that. Measles — because it is the most contagious of the vaccine-preventable diseases, the most contagious human disease really — it is the first to come back." Three large outbreaks in Canada, Mexico and the US now account for the overwhelming majority of roughly 2,300 measles cases across the World Health Organization's six-country Americas region, according to the health authority's update this week. Risk of measles is considered high in the Americas, and has grown 11-fold compared with 2024. Only slightly behind, data released earlier this week from the European Centre for Disease Prevention and Control (ECDC) and WHO also noted that measles cases across Europe were up tenfold in 2024 compared to 2023. That data also indicated that the 2024 measles cases in Europe followed a seasonal pattern, which was not previously noted in 2021 through 2023. Of the European cases, which reportedly hit 35,212 for 2024, 87% were reported in Romania. The ECDC said the dip in vaccine rates has impacted the recent spike in measles, with only three countries, Hungary, Malta and Portugal, having coverage of 95% or more for both doses of the measles vaccine.

There's 9,000 satellites circling the earth, the Guardian points out, with projections over over 60,000 by 2040.

But "A new study shows that the emissions from expired satellites, as they fall to Earth and burn up, will be significant in future years, with implications for ozone hole recovery and climate." Most old satellites are disposed of by reducing their altitude and letting them burn up as they fall, releasing pollution into Earth's atmosphere such as aerosolised aluminium. To understand the impact of these growing emissions from expired satellites, researchers simulated the effects associated with an annual release of 10,000 tonnes of aluminium oxide by 2040 (the amount estimated to be released from disposal of 3,000 satellites a year, assuming a fleet of 60,000 satellites).

The results, which are published in Journal of Geophysical Research Atmospheres, show that the re-entry material will accumulate at high latitudes and could result in temperature anomalies of up to 1.5C in the middle to upper atmosphere, reduction of wind speeds and ozone depletion, which could jeopardise ozone hole recovery.
"At present, impacts on the middle and the upper atmosphere are small," the researchers write, "but have the potential to increase." They argue that "to shed light upon the potential climate impacts of increased satellite reentry," an "expanded effort, including observations and modeling is needed."

Thanks to long-time Slashdot reader AmiMoJo for sharing the article.

"Researchers have created the first laboratory analog of the 'black hole bomb'," reports ScienceAlert, "a theoretical concept developed by physicists in the 1970s..."

There's no black hole involved; their experiment just simulates the "electromagnetic analogue" of the theoretical concept — the "exponential runaway amplification of spontaneously generated electromagnetic modes."

Or, as ScienceAlert puts it, "It doesn't, just to set your mind at ease, pose any danger. It consists of a rotating aluminum cylinder, placed inside layers of coils that generate magnetic fields that rotate around it, at controllable speeds." As Roger Penrose proposed in 1971, the powerful rotational energy of a spinning black hole could be used to amplify the energy of nearby particles. Then, physicist Yakov Zel'Dovich figured out that you didn't need a black hole to see this phenomenon in action. An axially symmetrical body rotating in a resonance chamber, he figured, could produce the same energy transfer and amplification, albeit on a much smaller scale. Later work by other physicists found that, if you enclose the entire apparatus in a mirror, a positive feedback loop is generated, amplifying the energy until it explodes from the system.

This concept was named the black hole bomb, and a team of physicists led by Marion Cromb of the University of Southampton in the UK now claim to have brought it to life. A paper describing their experiment has been uploaded to preprint server arXiv... [W]hat the team's experiment does is simulate it, using magnetic fields as a proxy for the particles, with the coils around the system acting as the reflector to produce the feedback loop. When they ran the experiment, they found that, when the cylinder is rotating faster than, and in the same direction as, the magnetic field, the magnetic field is amplified, compared to when there is no cylinder. When the cylinder rotates more slowly than the magnetic field, however, the magnetic field is dampened. This is a really interesting result, because it demonstrates a very clear amplification effect, based on the theories described decades ago...

Because we can't probe black holes directly, analogs such as this are an excellent way to understand their properties... [T]he experiment could represent a significant step towards better understanding the physics of the most gravitationally extreme objects in the Universe.
"The exponential amplification from noise supports theoretical investigations into black hole instabilities," the researchers write, "and is promising for the development of future experiments to observe quantum friction in the form of the Zeldovich effect seeded by the quantum vacuum..."

Long-time Slashdot reader piojo writes: Tim Friede, Wisconsin man, has been injecting himself with snake venom for 18 years to gain protection from his pet snakes. The antibodies he developed have formed two components of a three-part antivenom, which gives partial or total protection against 18 of 19 species of venomous snakes that were tested. Notably, the antivenom is ineffective against vipers.
From Australia's public broadcaster ABC: The team's results have been published today in the journal Cell... The new antivenom described in the study is very different to traditional antivenoms, according to Peter Kwong, a biochemist at Columbia University and one of the study's authors.
The scientists call their new antivenom "unparallel," according to the BBC, though the snake enthusiast (a former truck mechanic) had "initially wanted to build up his immunity to protect himself when handling snakes, documenting his exploits on YouTube." The team is trying to refine the antibodies further and see if adding a fourth component could lead to total protection against elapid snake venom... "Tim's antibodies are really quite extraordinary — he taught his immune system to get this very, very broad recognition," said Professor Peter Kwong [one of the researchers at Columbia University].
In a video interview, CNN shows footage of the man inducing snake bites (calling it "a classic do-not-try-this-at-home moment"). "I have a lot of notes in Excel files," he tells CNN, "where I hit these particular windows to where I know I can boost up before a bite."

"I don't just take the bite, because that can kill you. I properly boost up, and methodically take notes, and weigh the venomes out very specifically..."

Slashdot reader sciencehabit shares this excerpt from a new article in Science magazine: At first, astronomers knew of only one cosmic scenario that fit the bill for the violent formation of "jewelry shop" elements [gold and sliver]: the collision of two ultra-dense stellar corpses called neutron stars.

Now, a second has stepped onto the scene.

As they report this week in The Astrophysical Journal Letters, researchers have discovered signatures of this heavy element formation — called the r-process — in a giant flare first detected from a highly magnetic neutron star in 2004. The flare, which released more energy than our Sun does in a million years as it spewed electrically charged material, has remained shrouded in mystery since its discovery 20 years ago. Researchers quickly traced the outburst to a nearby magnetar, a special breed of neutron star whose magnetic fields are trillions times stronger than Earth's. But ten minutes after the massive flare, a second, fainter signal inexplicably came from the same star.

More r-process sources may still be looming in the dark. The new study accounts for about 10% of the Milky Way's heavy elements, suggesting that astronomers will have to scour the cosmos for even more places where the r-process is hiding. One potential spot is a rare type of supernova that births rapidly rotating neutron stars, says says Anirudh Patel, the new study's lead author and an astronomer at Columbia University. He hopes that with more observations, astronomers will be able to sharpen that picture.... "It's humbling to realize that these were made in such extreme astrophysical environments."

Astronomers may have found the best candidate yet for the elusive Planet Nine: a mysterious object in infrared sky surveys taken 23 years apart that appears to be more massive than Neptune and about 700 times farther from the sun than Earth. Space.com reports: [A] team led by astronomer Terry Long Phan of the National Tsing Hua University in Taiwan has delved into the archives of two far-infrared all-sky surveys in search of Planet Nine -- and incredibly, they have found something that could possibly be Planet Nine. The Infrared Astronomy Satellite, IRAS, launched in 1983 and surveyed the universe for almost a year before being decommissioned. Then, in 2006, the Japanese Aerospace Exploration Agency (JAXA) launched AKARI, another infrared astronomy satellite that was active between 2006 and 2011. Phan's team were looking for objects that appeared in IRAS's database, then appeared to have moved by the time AKARI took a look. The amount of movement on the sky would be tiny -- about three arcminutes per year at a distance of approximately 700 astronomical units (AU). One arcminute is 1/60 of an angular degree.

But there's an extra motion that Phan's team had to account for. As the Earth orbits the sun, our view of the position of very distant objects changes slightly in an effect called parallax. It is the same phenomenon as when you hold your index finger up to your face, close one eye and look at your finger, and then switch eyes -- your finger appears to move as a result of you looking at it from a slightly different position. Planet Nine would appear to move on the sky because of parallax as Earth moves around the sun. On any particular day, it might seem to be in one position, then six months later when Earth is on the other side of the sun, it would shift to another position, perhaps by 10 to 15 arcminutes -- then, six months after that, it would seem to shift back to its original position. To remove the effects of parallax, Phan's team searched for Planet Nine on the same date every year in the AKARI data, because on any given date it would appear in the same place, with zero parallax shift, every year. They then also scrutinized each candidate object that their search threw up on an hourly basis. If a candidate is a fast-moving, nearby object, then its motion would be detectable from hour to hour, and could therefore be ruled out. This careful search led Phan's team to a single object, a tiny dot in the infrared data.

It appears in one position in IRAS's 1983 image, though it was not in that position when AKARI looked. However, there is an object seen by AKARI in a position 47.4 arcminutes away that isn't there in the IRAS imagery, and it is within the range that Planet Nine could have traveled in the intervening time. In other words, this object has moved a little further along its orbit around the sun in the 23 or more years between IRAS and AKARI. The knowledge of its motion in that intervening time is not sufficient to be able to extrapolate the object's full orbit, therefore it's not yet possible to say for certain whether this is Planet Nine. First, astronomers need to recover it in more up-to-date imagery. [...] Based on the candidate object's brightness in the IRAS and AKARI images, Phan estimates that the object, if it really is Planet Nine, must be more massive than Neptune. This came as a surprise, because he and his team were searching for a super-Earth-size body. Previous surveys by NASA's Wide-field Infrared Survey Explorer (WISE) have ruled out any Jupiter-size planets out to 256,000 AU, and any Saturn-size planets out to 10,000 AU, but a smaller Neptune or Uranus-size world could still have gone undetected. Phan told Space.com that he had searched for his candidate in the WISE data, "but no convincing counterpart was found because it has moved since the 2006 position," and without knowing its orbit more accurately, we can't say where it has moved to. "Once we know the position of the candidate, a longer exposure with the current large optical telescopes can detect it," Phan told Space.com. "However, the follow-up observations with optical telescopes still need to cover about three square degrees because Planet Nine would have moved from the position where AKARI detected it in 2006. This is doable with a camera that has a large field of view, such as the Dark Energy Camera, which has a field of view of three square degrees on the Blanco four-meter telescope [in Chile]."

An anonymous reader shares a report: In the nearly two months since former Google chief executive Eric Schmidt acquired Relativity Space, the billionaire has not said much publicly about his plans for the launch company. However, his intentions for Relativity now appear to be increasingly clear: He wants to have the capability to launch a significant amount of computing infrastructure into space.

We know this because Schmidt appeared before the House Committee on Energy and Commerce during a hearing in April, speaking on the future of AI and US competitiveness. Among the topics raised then was the need for more electricity -- both renewable and non-renewable -- to power data centers that will facilitate the computing needs for AI development and applications. Schmidt noted that an average nuclear power plant in the United States generates 1 gigawatt of power.

"People are planning 10 gigawatt data centers," Schmidt said. "Gives you a sense of how big this crisis is. Many people think that the energy demand for our industry will go from 3 percent to 99 percent of total generation. One of the estimates that I think is most likely is that data centers will require an additional 29 gigawatts of power by 2027, and 67 more gigawatts by 2030. These things are industrial at a scale that I have never seen in my life."