For the first time -- and despite fears that it might never happen -- nations have agreed a series of measures to prevent, prepare for and respond to pandemics. Nature: The terms of the first global pandemic accord were still being hashed out at the World Health Organization (WHO) headquarters in Geneva, Switzerland, up until the early hours of 16 April. "This is a definitive moment in the history of global health," says Lawrence Gostin, a specialist in health law and policy at Georgetown University in Washington DC, who followed the negotiations closely. The accord "sets out some very important norms to keep the world safe," he says.

The accord was agreed without the United States, which withdrew from the pandemic treaty the day that President Trump was inaugurated. This reduces its power, says Gostin, but is also a source of strength. "Instead of collapsing in the face of President Trump's assault on global health, the world came together." The treaty is not perfect but represents a major achievement, says Michelle Childs, policy advocacy director at the non-profit organization Drugs for Neglected Diseases Initiative in Geneva. "People didn't think that they'd get to this stage of agreeing at all."

An anonymous reader quotes a report from The Guardian: Fears that smartphones, tablets and other devices could drive dementia in later life have been challenged by research that found lower rates of cognitive decline in older people who used the technology. An analysis of published studies that looked at technology use and mental skills in more than 400,000 older adults found that over-50s who routinely used digital devices had lower rates of cognitive decline than those who used them less. It is unclear whether the technology staves off mental decline, or whether people with better cognitive skills simply use them more, but the scientists say the findings question the claim that screen time drives what has been called "digital dementia".

"For the first generation that was exposed to digital tools, their use is associated with better cognitive functioning," said Dr Jared Benge, a clinical neuropsychologist in UT Health Austin's Comprehensive Memory Center. "This is a more hopeful message than one might expect given concerns about brain rot, brain drain, and digital dementia." Benge and his colleague Dr Michael Scullin, a cognitive neuroscientist at Baylor University in Texas, analysed 57 published studies that examined the use of digital technology in 411,430 adults around the world. The average age was 69 years old and all had a cognitive test or diagnosis. The scientists found no evidence for the digital dementia hypothesis, which suggests that a lifetime of using digital technology drives mental decline. Rather, they found that using a computer, smartphone, the internet or some combination of these was associated with a lower risk of cognitive impairment. The details have been published in Nature Human Behaviour. "Using digital devices in the way that we use televisions -- passive and sedentary, both physically and mentally -- is not likely to be beneficial," said Scullin. "But, our computers and smartphones also can be mentally stimulating, afford social connections, and provide compensation for cognitive abilities that are declining with ageing. These latter types of uses have long been regarded as beneficial for cognitive ageing."

A Canadian math prodigy is accused of stealing over $65 million through complex exploits on decentralized finance platforms and is currently a fugitive from U.S. authorities. Despite facing criminal charges for fraud and money laundering, he has evaded capture by moving internationally, embracing the controversial "Code is Law" philosophy, and maintaining that his actions were legal under the platforms' open-source rules. The Globe and Mail reports: Andean Medjedovic was 18 years old when he made a decision that would irrevocably alter the course of his life. In the fall of 2021, shortly after completing a master's degree at the University of Waterloo, the math prodigy and cryptocurrency trader from Hamilton had conducted a complex series of transactions designed to exploit a vulnerability in the code of a decentralized finance platform. The maneuver had allegedly allowed him to siphon approximately $16.5-million in digital tokens out of two liquidity pools operated by the platform, Indexed Finance, according to a U.S. court document.

Indexed Finance's leaders traced the attack back to Mr. Medjedovic, and made him an offer: Return 90 per cent of the funds, keep the rest as a so-called "bug bounty" -- a reward for having identified an error in the code -- and all would be forgiven. Mr. Medjedovic would then be free to launch his career as a white hat, or ethical, hacker. Mr. Medjedovic didn't take the deal. His social media posts hinted, without overtly stating, that he believed that because he had operated within the confines of the code, he was entitled to the funds -- a controversial philosophy in the world of decentralized finance known as "Code is Law." But instead of testing that argument in court, Mr. Medjedovic went into hiding. By the time authorities arrived on a quiet residential street in Hamilton to search his parents' townhouse less than two months later, Mr. Medjedovic had moved out, taking his electronic devices with him.

Then, roughly two years later, he struck again, netting an even larger sum -- approximately $48.4-million -- by conducting a similar exploit on another decentralized finance platform, U.S. authorities allege. Mr. Medjedovic, now 22, faces five criminal charges -- including wire fraud, attempted extortion and money laundering -- according to a U.S. federal court document that was unsealed earlier this year. If convicted, he could be facing decades in prison. First, authorities will have to find him.

A new study projects that CT scans conducted in 2023 may result in around 103,000 future cancer cases in the U.S. due to low-dose ionizing radiation. "[I]t would put CT scans on par with other significant risk factors for cancer, like alcohol consumption, at least at a population level," reports ScienceAlert. From the report: At an individual level, the theoretical chance of developing cancer from a CT scan is thought to be very minimal, if it exists at all, and patients should not be scared of undergoing these tests if they are deemed medically necessary. However, the number of CT examinations performed each year in the US has increased by more than 30 percent since 2007, and researchers suggest that unwarranted tests are exposing the population to unnecessary radiation. [...]

The anonymous data comes from 143 hospitals and outpatient facilities across the US, catalogued in the UCSF International CT Dose Registry. Using statistics from 2016 to 2022, researchers predicted 93 million CT examinations were carried out in 2023, on roughly 62 million patients. Based on the associated radiation risks, the team estimates that CT scans in 2023 may be tied to 103,000 future cancers. The findings have been published in JAMA Internal Medicine.

Blue Origin's New Shepard completed its 31st mission Monday morning, carrying the first all-female crew to space since Soviet cosmonaut Valentina Tereshkova's 1963 solo flight. The NS-31 mission lifted off from West Texas at 9:30 a.m. EDT, with hundreds of thousands watching via livestream as the autonomous vehicle crossed the Karman line 62 miles above Earth.

The 10-minute suborbital journey carried six passengers: journalist and Bezos' fiancee Lauren SÃnchez, former NASA scientist Aisha Bowe, bioastronautics researcher Amanda Nguyen, CBS journalist Gayle King, pop star Katy Perry, and film producer Kerianne Flynn. Bowe conducted three research experiments during the flight, while Nguyen became the first Vietnamese and Southeast Asian woman in space. The fully reusable New Shepard system features a pressurized capsule that separates from its booster before returning to Earth with three parachutes.

"More than three million children around the world are thought to have died in 2022 as a result of infections that are resistant to antibiotics," reports the BBC, citing a study by two leading experts in child health that used data from sources including the World Health Organization and the World Bank: Experts say this new study highlights a more than tenfold increase in AMR-related infections in children in just three years. The number could have been made worse by the impact of the Covid pandemic...

The report's lead authors, Doctor Yanhong Jessika Hu of Murdoch Children's Research Institute in Australia and Professor Herb Harwell of the Clinton Health Access Initiative, point to a significant growth in the use of antibiotics that are meant to only be held back for the most serious infections. Between 2019 and 2021 the use of "watch antibiotics", drugs with a high risk of resistance, increased by 160% in South East Asia and 126% in Africa. Over the same period, "reserve antibiotics" — last-resort treatments for severe, multidrug-resistant infections — rose by 45% in South East Asia and 125% in Africa.

The authors warn that if bacteria develop resistance to these antibiotics, there will be few, if any, alternatives for treating multidrug-resistant infections.
"Antibiotics are ubiquitous around us," Professor Harwell warns in the article. "They end up in our food and the environment and so coming up with a single solution is not easy." The article also quotes a senior lecturer in microbiology at King's College London, who says the new study "marks a significant and alarming increase compared to previous data".

"These findings should serve as a wake-up call for global health leaders. Without decisive action, AMR could undermine decades of progress in child health, particularly in the world's most vulnerable regions."

Thanks to Slashdot reader Bruce66423 for sharing the article.

"Can you help me take down the Texas lottery?"

That's what a London banker-turned-bookmaker asked "acquaintances" in 2023, reports the Wall Street Journal. The plan was to buy "nearly every possible number in a coming drawing" — purchasing $1 tickets for 25.8 million possible combinations, since "The jackpot was heading to $95 million. If nobody else also picked the winning numbers, the profit would be nearly $60 million." Marantelli flew to the U.S. with a few trusted lieutenants. They set up shop in a defunct dentist's office, a warehouse and two other spots in Texas. The crew worked out a way to get official ticket-printing terminals. Trucks hauled in dozens of them and reams of paper... [Then Texas announced no winner in an earlier lottery, rolling its jackpot into another drawing three days later.] The machines — manned by a disparate bunch of associates and some of their children — screeched away nearly around the clock, spitting out 100 or more tickets every second. Texas politicians later likened the operation to a sweatshop.

Trying to pull off the gambit required deep pockets and a knack for staying under the radar — both hallmarks of the secretive Tasmanian gambler who bankrolled the operation. Born Zeljko Ranogajec, he was nicknamed "the Joker" for his ability to pull off capers at far-flung casinos and racetracks. Adding to his mystique, he changed his name to John Wilson several decades ago. Among some associates, though, he still goes by Zeljko, or Z. Over the years, Ranogajec and his partners have won hundreds of millions of dollars by applying Wall Street-style analytics to betting opportunities around the world. Like card counters at a blackjack table, they use data and math to hunt for situations ripe for flipping the house edge in their favor. Then they throw piles of money at it, betting an estimated $10 billion annually.

The Texas lottery play, one of their most ambitious operations ever, paid off spectacularly with a $57.8 million jackpot win. That, in turn, spilled their activities into public view and sparked a Texas-size uproar about whether other lotto players — and indeed the entire state — had been hoodwinked. Early this month, the state's lieutenant governor, Dan Patrick, called the crew's win "the biggest theft from the people of Texas in the history of Texas." In response to written questions addressed to Marantelli and Ranogajec, Glenn Gelband, a New Jersey lawyer who represents the limited partnership that claimed the Texas prize, said "all applicable laws, rules and regulations were followed...."

Lottery officials and state lawmakers have taken steps to prevent a repeat.
The article also looks at a group of Princeton University graduates calling themselves Black Swan Capital that's "won millions in recent years" by targetting state lottery drawings with unusually favorable odds.

"State lottery directors say they are seeing more organized efforts to buy lottery tickets in bulk," according to the article, "but that the groups are largely operating legally and transparently..."

"Researchers say that a person's intelligence plays a bigger role in their computer proficiency than previously believed," writes SciTechDaily, "so much so that practice alone may not be enough to ensure ease of use."

A new study has found that general cognitive abilities, such as perception, reasoning, and memory, are more important than previously believed in determining a person's ability to perform everyday tasks on a computer... "It is clear that differences between individuals cannot be eliminated simply by means of training," says Antti Oulasvirta [a professor at Finland's Aalto University who conducted extensive human-computer interaction research with his team and the University of Helsinki Department of Psychology]. "In the future, user interfaces need to be streamlined for simpler use. This age-old goal has been forgotten at some point, and awkwardly designed interfaces have become a driver for the digital divide.

"We cannot promote a deeper and more equal use of computers in society unless we solve this basic problem," Oulasvirta says...

This is the first-ever study to measure users' actual ability to perform daily tasks on a PC, as previous studies have relied on participants self-assessing their abilities via questionnaires... "The study revealed that, in particular, working memory, attention, and executive functions stand out as the key abilities. When using a computer, you must determine the order in which things are done and keep in mind what has already been done. A purely mathematical or logical ability does not help in the same way," says university lecturer Viljami Salmela [from the University of Helsinki].
"Our results suggest that contemporary user interfaces are getting so complex that their design is starting to affect inclusivity," their paper concludes, saying that it ultimately raises a question. "How can we design user interfaces to decrease the role of cognitive abilities."

Black holes "often exhibit long periods of dormancy," writes Popular Science, adding that astronomers had never witnessed a black hole "wake up" in real time. "Until now..."

In February of 2024 X-ray bursts were spotted coming out of a black hole named Ansky by Lorena Hernández-García at Chile's Valparaiso University, according to the article. And what astronomers have now seen "challenges prevailing theories about black hole lifecycles." Hernández-García and collaborators then determined the black hole was displaying a phenomenon known as a quasiperiodic eruption, or QPE [a short-lived flaring event...] While a black hole inevitably destroys everything it captures, objects behave differently during their impending demise. A star, for example, generally stretches apart into a bright, hot, fast-spinning disc known as an accretion disc. Most astronomers have theorized that black holes generate QPEs when a comparatively small object like a star or even a smaller black hole collides with an accretion disc. In the case of Ansky, however, there isn't any evidence linking it to the death of a star.

"The bursts of X-rays from Ansky are ten times longer and ten times more luminous than what we see from a typical QPE," said MIT PhD student and study co-author Joheen Chakraborty. "Each of these eruptions is releasing a hundred times more energy than we have seen elsewhere. Ansky's eruptions also show the longest cadence ever observed, of about 4.5 days." Astronomers must now consider other explanations for Ansky's remarkable behavior. One theory posits that the accretion disc could come from nearby galactic gas pulled in by the black hole instead of a star. If true, then the X-rays may originate from high energy shocks to the disc caused by a small cosmic object repeatedly passing through and disrupting orbital matter.
It's detailed in a study published on April 11 in Nature Astronomy....

Meanwhile, scientists "have uncovered the strongest evidence yet for the existence of elusive intermediate-mass black holes," reports SciTechDaily.

And there's more black hole news from RockDoctor (Slashdot reader #15,477): Given the recent work on galaxy-centre Super-Massive Black Holes (SMBHs), you may be surprised to learn that the only Stellar-Mass Black Holes (SMBHs ... uh, "BHs") identified to-date have been by their gravitational waves, as they merge with another BH or a neutron star. But the long-running OGLE (Optical Gravitational Lensing Experiment) project (1992 — present) has recently confirmed that it has detected an isolated BH not orbiting another bright object, or "swallowing" much of anything...

In this case, 16 other telescopes performed sensitive astrometry (position measurement) over 11 years including the Hubble Space Telescope (HST). These multiple measurements plot an ellipse on the sky, mirroring the movement of the Earth around it's orbit — parallax. Which means this is a relatively close object (1520 parsecs / ~5000 light years).... And there is no sign of a third light emitting body nearby, which means this is an isolated black hole, not orbiting any other body (or, indeed, with any other [small] star orbiting it).

Abstract of a paper on NBER: There is much disagreement about the extent to which financial incentives motivate study participants. We elicit preferences for being paid for completing a survey, including a one-in-twenty chance of winning a $100 electronic gift card, a guaranteed electronic gift card with the same expected value, and an option to refuse payment. More than twice as many participants chose the lottery as chose the guaranteed payment. Given that most people are risk averse, this pattern suggests that factors beyond risk preferences -- such as hassle costs -- influenced their decision-making. Almost 20 percent of participants actively refused payment, demonstrating low monetary motivation. We find both systematic and unobserved heterogeneity in the characteristics of who turned down payment. The propensity to refuse payment is more than four times as large among individuals 50 and older compared to younger individuals, suggesting a tradeoff between financially motivating participants and obtaining a representative sample. Overall, our results suggest that modest electronic gift card payments violate key requirements of Vernon Smith's induced value theory.

Germany will get a new "super-high-tech ministry" responsible for research, technology, and aerospace, according to the coalition agreement published by the incoming government this week. From a report: The announcement is one of several nods to science in the 144-page agreement, unveiled on 9 April following weeks of negotiations between the center-right Christian Democrats (CDU) and its sister party, the Christian Social Union in Bavaria (CSU) -- who together won the most seats in February's federal elections -- and the center-left Social Democrats. The agreement is expected to be formally approved by the three parties by early May, paving the way for CDU leader Friedrich Merz to be elected chancellor.

[...] The new agreement lists a number of scientific priorities for the new government, including support for artificial intelligence, quantum technologies, biotechnology, microchip development and production, and fusion energy. "Our goal is that the world's first fusion reactor should be realized in Germany," the text states. It also mentions personalized medicine, oceans research, and sustainability research as "strategic" areas. But the agreement does not include any budget estimates, and observers caution it is unclear where the money for new programs would come from. The agreement does affirm current commitments to increase the budgets of the country's main research organizations by 3% per year through 2030.

The Food and Drug Administration says it would begin phasing out animal testing requirements for antibody therapies and other drugs and move toward AI-based models and other tools it deems "human-relevant." Axios: The FDA said it would launch a pilot program over the next year allowing select developers of monoclonal antibodies to use a primarily non-animal-based testing strategy. Commissioner Marty Makary in a statement said the shift would improve drug safety, lower research and development costs and address ethical concerns about animal experimentation.

Scientists have recreated in a laboratory the sensory pathway that transmits feelings of pain to the human brain, in a breakthrough that could lead to better treatments. Financial Times: A team at Stanford University in California is the first to combine different neurons grown from human stem cells into a functioning brain circuit in a lab dish. Their experiments, published in Nature on Wednesday, illustrate scientists' rapid progress in replicating living tissues and organs through synthetic biology.

When the Stanford scientists exposed the brain circuit they had created to sensory stimulants, they observed waves of electrical activity travelling along it. The molecule that makes chilli peppers hot, capsaicin, immediately induced a strong response.

[...] The synthetic brain circuits could be used to screen for better-targeted therapies for pain that tone down excessive waves of neurotransmission, without affecting the brain's reward circuitry as opioids do, project leader [Sergiu] Pasca said. The assembloids themselves cannot be said to "feel pain," he emphasised: "They transmit nervous signals that are processed by a second pathway going deeper into the brain and giving us the aversive, emotional component of pain."

New research suggests that given the right kind of training, AI bots can deliver mental health therapy with as much efficacy as -- or more than -- human clinicians. From a report: The recent study, published in the New England Journal of Medicine, shows results from the first randomized clinical trial for AI therapy. Researchers from Dartmouth College built the bot as a way of taking a new approach to a longstanding problem: The U.S. continues to grapple with an acute shortage of mental health providers. "I think one of the things that doesn't scale well is humans," says Nick Jacobson, a clinical psychologist who was part of this research team. For every 340 people in the U.S., there is just one mental health clinician, according to some estimates.

While many AI bots already on the market claim to offer mental health care, some have dubious results or have even led people to self-harm. More than five years ago, Jacobson and his colleagues began training their AI bot in clinical best practices. The project, says Jacobson, involved much trial and error before it led to quality outcomes. "The effects that we see strongly mirror what you would see in the best evidence-based trials of psychotherapy," says Jacobson. He says these results were comparable to "studies with folks given a gold standard dose of the best treatment we have available."

Colossal Biosciences has claimed it "successfully restored" the extinct dire wolf after a "10,000+ year absence," but scientists clarify these are actually genetically modified grey wolves. The U.S. company announced three pups -- males Remus and Romulus born in October, and female Khaleesi born in January -- as dire wolves, but made only 20 genetic edits to grey wolves.

Beth Shapiro of Colossal told New Scientist that just 15 modifications were based on dire wolf DNA, primarily targeting size, musculature and ear shape. Five other changes involve mutations known to produce light coats in grey wolves. A 2021 DNA study revealed dire wolves and grey wolves last shared a common ancestor about 6 million years ago, with jackals and African wild dogs more closely related to grey wolves.

The internet's physical mass remains contested among scientists, with estimates ranging from a strawberry to something almost unimaginably small. In 2006, Harvard physicist Russell Seitz calculated the internet weighed roughly 50 grams based on server energy, a figure that would now equate to potato-weight given internet growth.

Christopher White, president of NEC Laboratories America, has dismissed this calculation as "just wrong." White suggests a more accurate method that accounts for the energy needed to encode all internet data in one place, yielding approximately 53 quadrillionths of a gram at room temperature. Alternatively, if the internet's projected 175 zettabytes of data were stored in DNA -- a storage medium scientists are actively exploring -- it would weigh 960,947 grams, equivalent to 10.6 American males. Though scientists debate measurement methods, White asserts the web's true complexity makes it "essentially unknowable."

Scientists "demonstrated a promising step toward using a person's own immune cells to fight gastrointestinal cancers" at America's National Institutes of Health (or NIH), reports the Washington Post.

But the results were published in Nature Medicine on Tuesday — "the same day the agency was hit with devastating layoffs..." The treatment approach is still early in its development; the personalized immunotherapy regimen shrank tumors in only about a quarter of the patients with colon, rectal and other GI cancers enrolled in a clinical trial. But a researcher who was not involved in the study called the results "remarkable" because they highlight a path to a frustratingly elusive goal in medicine — harnessing a person's own immune defenses to target common solid tumor cancers. Until now, cell-based immunotherapy has worked mainly on blood cancers, such as leukemia, but not the solid cancers that seed tumors in the breast, brain, lungs, pancreas and GI tract...

But the progress arrives at a sad time for science — and for patients, said the leader of the work, NIH immunotherapy pioneer Steven Rosenberg. Two patients' treatments using the experimental therapy had to be delayed because NIH's capacity to make personalized cell therapies has been slowed by the firing of highly skilled staff and by purchasing slowdowns. Those occurred even before major layoffs took place Tuesday... The Department of Health and Human Services (HHS) responded to an email asking about clinical trial delays with a statement: "NIH and HHS are complying with President Trump's executive order."
It's "a very exciting study," said Patrick Hwu, president of the Moffitt Cancer Center in Tampa. Finding ways to tailor this cell-based immunotherapy approach to common solid tumors that cause the vast majority of cancer deaths has remained a major scientific challenge... Rosenberg and colleagues first tried to create tumor infiltrating lymphocytes [or "TILs"] using the method that worked in melanoma for 18 patients with GI cancers that had spread. It failed completely. In a second iteration, his team sequenced the mutations present in each patient's tumor and used that information to sift out and expand the TILs that could home in on that patient's specific tumor cells. The results were far from a triumph, but provided a clue — this time, three of 39 patients' tumors shrank. In the last stage of the trial, the scientists added a drug called pembrolizumab that takes the brakes off immune cells. This time, eight of the 34 patients responded.

"Right now, only a few labs in the country can do what they just did," Hwu said.
While Rosenberg is already working "to refine and improve upon the results," he told the Post that two scientists involved in the specialized process of preparing the cells to treat patients were fired in the probationary purge. "We've had to slow down our work and delay the treatment of some patients...."

And there's also dramatically fewer people now who can purchase research materials, which the Post says it "making it slower and more difficult to obtain supplies."

Nuclear fusion — which releases four times the energy of fission — could theoretically happen sooner in space than on earth, reports CNN.

"And it could help spacecraft achieve speeds of up to 500,000 miles (805,000 kilometers) per hour — more than the fastest object ever built..." With funding from the UK Space Agency, British startup Pulsar Fusion has unveiled Sunbird, a space rocket concept designed to meet spacecraft in orbit, attach to them, and carry them to their destination at breakneck speed using nuclear fusion... For now, Sunbird is in the very early stages of construction and it has exceptional engineering challenges to overcome, but Pulsar says it hopes to achieve fusion in orbit for the first time in 2027. [Pulsar's founder/CEO says the first functional Sunbird would be ready four to five years later.]

If the rocket ever becomes operational, it could one day cut the journey time of a potential mission to Mars in half.
CNN says the proposed Sunbird process would use helium-3 — which may be abundant on the Moon — to generate protons which "can be used as a 'nuclear exhaust' to provide propulsion". (And without generating any dangerous radioactive material.) "It's very unnatural to do fusion on Earth," says Richard Dinan, founder and CEO of Pulsar. "Fusion doesn't want to work in an atmosphere. Space is a far more logical, sensible place to do fusion, because that's where it wants to happen anyway...."

Sunbirds would operate similarly to city bikes at docking stations, according to Dinan: "We launch them into space, and we would have a charging station where they could sit and then meet your ship," he says. "You turn off your inefficient combustion engines, and use nuclear fusion for the greater part of your journey. Ideally, you'd have a station somewhere near Mars, and you'd have a station on low Earth orbit, and the (Sunbirds) would just go back and forth...." Initially, the Sunbirds will be offered for shuttling satellites in orbit, but their true potential would come into play with interplanetary missions. The company illustrates a few examples of the missions that Sunbird could unlock, such as delivering up to 2,000 kilograms (4,400 pounds) of cargo to Mars in under six months, deploying probes to Jupiter or Saturn in two to four years (NASA's Europa Clipper, launched in 2024 towards one of Jupiter's moons, will arrive after 5.5 years), and an asteroid mining mission that would complete a round trip to a near-Earth asteroid in one to two years instead of three.

Other companies are working on nuclear fusion engines for space propulsion, including Pasadena-based Helicity Space, which received investment from aerospace giant Lockheed Martin in 2024. San Diego-based General Atomics and NASA are working on another type of nuclear reactor — based on fission rather than fusion — which they plan to test in space in 2027.

"I started working on Voyager in 1977," the Voyager mission's project scientist told Gizmodo Saturday in a new interview. "It was my first job out of college."

35 years later, a Voyager probe became the first spacecraft to cross into interstellar space in 2012, with Voyager 2 following in 2018. But while each Voyager spacecraft carries 10 scientific instruments, all but three have now been turned off to conserve power, Gizmodo writes. "The two spacecraft now have enough power to operate for another year or so before engineers are forced to turn off two more instruments..." Voyager Mission Project Scientist Linda Spilker: The number of people that are working on and flying Voyager is a whole lot smaller than it was in the planetary days... The challenge was, can we reach the heliopause? We didn't know where it was, we had no idea how far away it was. We got to Neptune, and then we thought, "well, maybe it's just another 10 [astronomical units] or so, a little bit further, a little bit further." And so every time we got a little bit further, the modelers would go back, scratch their heads and say, "ah, it could be a little bit more, a little bit farther away," and so on and on that continued, until finally, Voyager 1 crossed the heliopause in 2012...

Gizmodo: Is it an emotional decision to turn off Voyager's instruments?

Spilker: I was talking to the cosmic ray instrument lead, and I said, "Wow, this must really be tough for you to see your instrument turned off." He helped build the instrument in the early 1970s. This instrument that's been sending you data, and that's been part of your life for over 50 years now. And he said, it was hard to think about turning it off for the whole team. It's kind of like losing a best friend, or someone that's been a part of your life for so many years, and then suddenly, it's silent. At the same time, there's this pride that you were part of that, and your instrument got so much great data — so it's a mix of emotions...

The spacecraft had a lot of redundancy on it, so that means two of every computer and two of all the key components. We've been able to turn off those backup units, but we're now at the point where, to really get a significant amount of power, all that's left are some of the science instruments to turn off. So, that's where we're at... How cold can the lines get before they freeze? How cold can some of these other components get before they stop working? So that's another challenge. Then there are individual tiny thrusters that align the spacecraft and keep that antenna pointed at the Earth so we can send the data back, and they're very slowly clogging up with little bits of silica, and so their puffs are getting weaker and weaker. That's another challenge that we're going through to balance.

But we're hopeful that we can get one, possibly two, spacecraft to the 50th anniversary in 2027. Voyager's golden anniversary, and perhaps even into the early 2030s with one, maybe two, science instruments.
"We're well past the warranty of four years..." Spilker says at one point. And "We're still working and thinking about an interstellar probe that would go much, much farther than Voyager.

"You're talking about a multi-generation mission."

The Starliner spacecraft lost four thrusters while approaching the International Space Station last summer. NASA astronaut, Butch Wilmore took manual control, remembers Ars Technica, "But as Starliner's thrusters failed, Wilmore lost the ability to move the spacecraft in the direction he wanted to go..." Starliner had flown to within a stone's throw of the space station, a safe harbor, if only they could reach it. But already, the failure of so many thrusters violated the mission's flight rules. In such an instance, they were supposed to turn around and come back to Earth. Approaching the station was deemed too risky for Wilmore and Williams, aboard Starliner, as well as for the astronauts on the $100 billion space station.

But what if it was not safe to come home, either?

"I don't know that we can come back to Earth at that point," Wilmore said in an interview. "I don't know if we can. And matter of fact, I'm thinking we probably can't."
After a half-hour exclusive interview, Ars Technica's senior space editor Eric Berger says he'd heard "a hell of a story." After Starliner lost four of its 28 reaction control system thrusters, Van Cise and this team in Houston decided the best chance for success was resetting the failed thrusters. This is, effectively, a fancy way of turning off your computer and rebooting it to try to fix the problem. But it meant Wilmore had to go hands-off from Starliner's controls. Imagine that. You're drifting away from the space station, trying to maintain your position. The station is your only real lifeline because if you lose the ability to dock, the chance of coming back in one piece is quite low. And now you're being told to take your hands off the controls...

Two of the four thrusters came back online.

Wilmore: "...But then we lose a fifth jet. What if we'd have lost that fifth jet while those other four were still down? I have no idea what would've happened. I attribute to the providence of the Lord getting those two jets back before that fifth one failed...

Berger: Mission Control decided that it wanted to try to recover the failed thrusters again. After Wilmore took his hands off the controls, this process recovered all but one of them. At that point, the vehicle could be flown autonomously, as it was intended to be.
"Wilmore added that he felt pretty confident, in the aftermath of docking to the space station, that Starliner probably would not be their ride home," according to the article. And Williams says it was the right decision. Publicly, NASA and Boeing expressed confidence in Starliner's safe return with crew. But Williams and Wilmore, who had just made that harrowing ride, felt differently.