Zynga is the developer behind Farmville, a game once mostly played on Facebook, which at its peak attracted 82 million players a month.
Zynga now has its own games platform, but players will no longer be able to share their progress on Facebook.
Zynga's share price fell by 13% in after-hours trading following the news. It is the latest blow for the company, which last month announced job cuts and studio closures.
The change, which will take place from 31 March 2013, ends Zynga's ability to promote its Zynga.com platform on Facebook.